Results 81 to 90 of about 216,179 (302)

Phenotypic diversity drives paracrine drug tolerance

EMBO Molecular Medicine, 2017
Considerable clinical successes have been achieved in cancer treatment since the introduction of targeted therapies. However, almost inevitably tumors develop therapy resistance, which limits durable clinical responses.
Thomas Kuilman, Daniel S Peeper
doaj   +1 more source

Macrophage heterogeneity in tissues: phenotypic diversity and functions [PDF]

Immunological Reviews, 2014
SummaryDuring development and throughout adult life, macrophages derived from hematopoietic progenitors are seeded throughout the body, initially in the absence of inflammatory and infectious stimuli as tissue‐resident cells, with enhanced recruitment, activation, and local proliferation following injury and pathologic insults.
Gordon, Siamon, Plüddemann, Annette, Martinez, Fernando   +2 more
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Geographical variation and genetic diversity of Parashorea chinensis germplasm resources

Frontiers in Plant Science
IntroductionParashorea chinensis is a rare monodominant species in southwest China known for its production of high-quality timber, is facing decline due to its narrow distribution, human interference and habitat destruction.
Yuanyuan Xu, Yuanyuan Xu, Shinan Liu, Shinan Liu, Patrick M. Finnegan, Fang Liu, Izhar Ali, Izhar Ali, Haidong Zhang, Haidong Zhang, Mei Yang, Mei Yang   +11 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Morphological Characterization of A. vineale

Yüzüncü Yıl Üniversitesi Tarim Bilimleri Dergisi, 2021
Allium vineale L. is a wild edible Allium species. This species is collected from nature by the local people in the Eastern Anatolia Region of Turkey and consumed as a vegetable. Aboveground organs of A.
Özlem ÇAKMAKCI, Suat ŞENSOY, Ali R. ALAN, Çeknas ERDİNÇ   +3 more
doaj   +1 more source

Dimensions of hepatocellular carcinoma phenotypic diversity

World Journal of Gastroenterology, 2018
Hepatocellular carcinoma (HCC) is the 3rd leading cause of cancer-related death worldwide. More than 80% of HCCs arise within chronic liver disease resulting from viral hepatitis, alcohol, hemochromatosis, obesity and metabolic syndrome or genotoxins. Projections based on Western lifestyle and its metabolic consequences anticipate a further increase in
Desert, Romain, Nieto, Natalia, Musso, Orlando   +2 more
openaire   +4 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Utilization of molecular, phenotypic and geographical diversity to develop compact composite core collection in the oilseed crop, Safflower (Carthamus tinctorius L.) through maximization strategy

Frontiers in Plant Science, 2016
Carthamus tinctorius L. is a dryland oilseed crop yielding high quality edible oil. Previous studies have described significant phenotypic variability in the crop and used geographical distribution and phenotypic trait values to develop core collections.
Shivendra Kumar, Heena Ambreen, Murali Tottekkad Variath, Murali Tottekkad Variath, Atmakuri Ramakrishna Rao, Manu Agarwal, Amar Kumar, Shailendra Goel, Arun Jagannath   +8 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source