Results 101 to 110 of about 225,833 (307)
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
The landscape of microbial phenotypic traits and associated genes [PDF]
Nucleic Acids Research, 2016 Bacteria and Archaea display a variety of phenotypic traits and can adapt to diverse ecological niches. However, systematic annotation of prokaryotic phenotypes is lacking. We have therefore developed ProTraits, a resource containing ∼545 000 novel phenotype inferences, spanning 424 traits assigned to 3046 bacterial and archaeal species.
Brbić, Maria +5 more
openaire +5 more sources
Phenotypic traits for male Savannah sparrows [PDF]
, 2014 Phenotypic traits for male Savannah ...
Nathaniel T. Wheelwright (7593974) +5 more
core +3 more sources
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Evaluation of body condition score measured throughout lactation as an indicator of fertility in dairy cattle [PDF]
, 2004 Body condition score (BCS) records of primiparous Holstein cows were analyzed both as a single measure per animal and as repeated measures per sire of cow.
Banos, G +3 more
core +1 more source
Phenotypic Selection on a Heritable Size Trait Revisited
The American Naturalist, 2001 One of evolutionary biology's most persistent puzzles is the fact that apparent directional selection on a heritable trait in a natural population often does not produce a selection response. We tested three possible explanations for this problem using data on body size of more than 23,000 individuals, measured over 18 yr, in a collared flycatcher ...
Kruuk, L, Merilä, J, Sheldon, B
openaire +3 more sources
Study on Phenotypic Variation in Wild Populations of Prunella vulgaris
HorticulturaeObjective: This study aimed to clarify the variation law of phenotypic traits such as the stem, leaf, flower, main branch ear and seed of Prunella vulgaris Linnaeus. (P.
Xiaoyu Wu +12 more
doaj +1 more source
Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone +8 more
wiley +1 more source
Dissection of heterogeneous phenotypes for quantitative trait mapping
Genetic Epidemiology, 2005 We discuss analyses of Genetic Analysis Workshop 14 data from the Collaborative Study on the Genetics of Alcoholism (COGA) as well as from a simulated complex disease, Kofendrerd personality disorder (KPD), with both genetic and phenotypic heterogeneity. Both data sets included numerous related phenotypes in addition to disease definitions.
Bickeboeller, Heike +4 more
openaire +3 more sources
BMC Genetics, 2018 Background Diversity in crops is fundamental for plant breeding efforts. An accurate assessment of genetic diversity, using molecular markers, such as single nucleotide polymorphism (SNP), must be able to reveal the structure of the population under ...
Martin E. Tagliotti +7 more
doaj +1 more source