Results 81 to 90 of about 225,833 (307)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

THE ESTIMATION OF CARCASS TRAITS OF BALI BULLS USING ULTRASOUND [PDF]

, 2010
A study was conducted to collect information on Bali bulls carcass traits estimation as one of the selection criteria using ultrasound. Ultrasonic estimation of carcass traits such as M. longissimus thoracis area (MLTA), Subcutaneous Fat Thickness (SFT)
Sri Rachma, AB, Harada, H
core  

How much can the orientation of G's eigenvectors tell us about genetic constraints? [PDF]

, 2012
A key goal in evolutionary quantitative genetics is to understand how evolutionary trajectories are constrained by pleiotropic coupling among multiple traits.
Daniel Berner, Berner, Daniel
core   +1 more source

Ochratoxin A adsorption phenotype: An inheritable yeast trait

The Journal of General and Applied Microbiology, 2012
This study aimed to evaluate the inheritance of the trait ochratoxin A adsorption in two wine strains of Saccharomyces cerevisiae and their 46 descendants. Each strain was inoculated in triplicate in test tubes containing 10 ml of must obtained from the Calabrian Zibibbo white grape variety, artificially contaminated with ochratoxin A to reach a total ...
Caridi A., Sidari R., Pulvirenti A., Meca G., RITIENI, ALBERTO   +4 more
openaire   +7 more sources

Prevalence of sexual dimorphism in mammalian phenotypic traits [PDF]

Nature Communications, 2017
AbstractThe role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits ...
Natasha A. Karp, Jeremy Mason, Arthur L. Beaudet, Yoav Benjamini, Lynette Bower, Robert E. Braun, Steve D.M. Brown, Elissa J. Chesler, Mary E. Dickinson, Ann M. Flenniken, Helmut Fuchs, Martin Hrabe de Angelis, Xiang Gao, Shiying Guo, Simon Greenaway, Ruth Heller, Yann Herault, Monica J. Justice, Natalja Kurbatova, Christopher J. Lelliott, K.C. Kent Lloyd, Ann-Marie Mallon, Judith E. Mank, Hiroshi Masuya, Colin McKerlie, Terrence F. Meehan, Richard F. Mott, Stephen A. Murray, Helen Parkinson, Ramiro Ramirez-Solis, Luis Santos, John R. Seavitt, Damian Smedley, Tania Sorg, Anneliese O. Speak, Karen P. Steel, Karen L. Svenson, Yuichi Obata, Tomohiro Suzuki, Masaru Tamura, Hideki Kaneda, Tamio Furuse, Kimio Kobayashi, Ikuo Miura, Ikuko Yamada, Nobuhiko Tanaka, Atsushi Yoshiki, Shinya Ayabe, David A. Clary, Heather A. Tolentino, Michael A. Schuchbauer, Todd Tolentino, Joseph Anthony Aprile, Sheryl M. Pedroia, Lois Kelsey, Igor Vukobradovic, Zorana Berberovic, Celeste Owen, Dawei Qu, Ruolin Guo, Susan Newbigging, Lily Morikawa, Napoleon Law, Xueyuan Shang, Patricia Feugas, Yanchun Wang, Mohammad Eskandarian, Yingchun Zhu, Lauryl M. J. Nutter, Patricia Penton, Valerie Laurin, Shannon Clarke, Qing Lan, Khondoker Sohel, David Miller, Greg Clark, Jane Hunter, Jorge Cabezas, Mohammed Bubshait, Tracy Carroll, Sandra Tondat, Suzanne MacMaster, Monica Pereira, Marina Gertsenstein, Ozge Danisment, Elsa Jacob, Amie Creighton, Gillian Sleep, James Clark, Lydia Teboul, Martin Fray, Adam Caulder, Jorik Loeffler, Gemma Codner, James Cleak, Sara Johnson, Zsombor Szoke-Kovacs, Adam Radage, Marina Maritati, Joffrey Mianne, Wendy Gardiner, Susan Allen, Heather Cater, Michelle Stewart, Piia Keskivali-Bond, Caroline Sinclair, Ellen Brown, Brendan Doe, Hannah Wardle-Jones, Evelyn Grau, Nicola Griggs, Mike Woods, Helen Kundi, Mark N. D. Griffiths, Christian Kipp, David G. Melvin, Navis P. S. Raj, Simon A. Holroyd, David J. Gannon, Rafael Alcantara, Antonella Galli, Yvette E. Hooks, Catherine L. Tudor, Angela L. Green, Fiona L. Kussy, Elizabeth J. Tuck, Emma J. Siragher, Simon A. Maguire, David T. Lafont, Valerie E. Vancollie, Selina A. Pearson, Amy S. Gates, Mark Sanderson, Carl Shannon, Lauren F. E. Anthony, Maksymilian T. Sumowski, Robbie S. B. McLaren, Agnieszka Swiatkowska, Christopher M. Isherwood, Emma L Cambridge, Heather M. Wilson, Susana S. Caetano, Cecilia Icoresi Mazzeo, Monika H. Dabrowska, Charlotte Lillistone, Jeanne Estabel, Anna Karin B. Maguire, Laura-Anne Roberson, Guillaume Pavlovic, Marie-Christine Birling, Wattenhofer-Donze Marie, Sylvie Jacquot, Abdel Ayadi, Dalila Ali-Hadji, Philippe Charles, Philippe André, Elise Le Marchand, Amal El Amri, Laurent Vasseur, Antonio Aguilar-Pimentel, Lore Becker, Irina Treise, Kristin Moreth, Tobias Stoeger, Oana V. Amarie, Frauke Neff, Wolfgang Wurst, Raffi Bekeredjian, Markus Ollert, Thomas Klopstock, Julia Calzada-Wack, Susan Marschall, Robert Brommage, Ralph Steinkamp, Christoph Lengger, Manuela A. Östereicher, Holger Maier, Claudia Stoeger, Stefanie Leuchtenberger, AliÖ Yildrim, Lillian Garrett, Sabine M Hölter, Annemarie Zimprich, Claudia Seisenberger, Antje Bürger, Jochen Graw, Oliver Eickelberg, Andreas Zimmer, Eckhard Wolf, Dirk H Busch, Martin Klingenspor, Carsten Schmidt-Weber, Valérie Gailus-Durner, Johannes Beckers, Birgit Rathkolb, Jan Rozman, Shigeharu Wakana, David West, Sara Wells, Henrik Westerberg, Shay Yaacoby, Jacqueline K. White   +201 more
openaire   +8 more sources

Using mechanistic animal growth models to estimate genetic parameters of biological traits

Animal, 2007
Mechanistic animal growth models can incorporate a description of the genotype as represented by underlying biological traits that aim to specify the animal's genetic potential for performance, independent from the environmental factors captured by the ...
A.B. Doeschl-Wilson, P.W. Knap, B.P. Kinghorn, H.A.M. Van der Steen   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Experimental alteration of DNA methylation affects the phenotypic plasticity of ecologically relevant traits in Arabidopsis thaliana [PDF]

, 2010
Heritable phenotypic variation in plants can be caused not only by underlying genetic differences, but also by variation in epigenetic modifications such as DNA methylation.
Arcuri, Davide, Arcurri, D., Richards, Christina L., Bossdorf, Oliver, Bossdorf, O., Pigliucci, M., Pigliucci, Massimo   +6 more
core   +1 more source

The impact of environmental factors on phenotypic diversity of natural populations of Polyspora in China

Frontiers in Plant Science
BackgroundPlant phenotypic diversity is not solely determined by genetic variation but is also shaped by the combined effects of environmental factors. Polyspora, a genus within the Theaceae family, consists of evergreen trees or shrubs widely recognized
Changle Ma, Changle Ma, Maiyu Gong, Maiyu Gong, Qing Gui, Qing Gui, Zhifeng Fan, Jianxin Yang, Jianxin Yang, Lijuan Wang, Lijuan Wang, Lilan Deng   +11 more
doaj   +1 more source

Phenotypic divergence of traits that mediate antagonistic and mutualistic interactions between island and continental populations of the tropical plant, Tribulus cistoides (Zygophyllaceae)

Ecology and Evolution, 2023
Island systems have long served as a model for evolutionary processes due to their unique species interactions. Many studies of the evolution of species interactions on islands have focused on endemic taxa.
Winer Daniel Reyes‐Corral, Sofia Carvajal‐Endara, Molly Hetherington‐Rauth, Jaime A. Chaves, Peter R. Grant, B. Rosemary Grant, Andrew P. Hendry, Marc T. J. Johnson   +7 more
doaj   +1 more source