Results 61 to 70 of about 192,777 (261)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Frontiers in Plant ScienceBackgroundPlant phenotypic diversity is not solely determined by genetic variation but is also shaped by the combined effects of environmental factors. Polyspora, a genus within the Theaceae family, consists of evergreen trees or shrubs widely recognized
Changle Ma +11 more
doaj +1 more source
Ecology and Evolution, 2023 Island systems have long served as a model for evolutionary processes due to their unique species interactions. Many studies of the evolution of species interactions on islands have focused on endemic taxa.
Winer Daniel Reyes‐Corral +7 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Phenotypic characteristics of linear traits of udder and angularity in Holstein-Friesian cows and their correlation with milk yield traits [PDF]
Biotechnology in Animal Husbandry, 2020 Data set including 10860 primiparous Holstein-Friesian breed cows first calved in the period from 2011 to 2015, was used in determining phenotypic variability and correlation between the traits of milk yield and linearly estimated traits of udder and ...
Đedović Radica +7 more
doaj
Prevalence of sexual dimorphism in mammalian phenotypic traits [PDF]
Nature Communications, 2017 AbstractThe role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits ...
Natasha A. Karp +201 more
openaire +8 more sources
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Ecology and EvolutionThis study investigated leaf phenotypic variation in oak species to better understand how different groups of oaks adapt to diverse environmental conditions.
Xuan Li +4 more
doaj +1 more source
Phenotypic selection on floral traits in an urban landscape [PDF]
Proceedings of the Royal Society B: Biological Sciences, 2018 Native species are increasingly living in urban landscapes associated with abiotic and biotic changes that may influence patterns of phenotypic selection. However, measures of selection in urban and non-urban environments, and exploration of the mechanisms associated with such changes, are uncommon.
Rebecca E. Irwin +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source