Results 171 to 180 of about 192,777 (261)

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

Advanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen, Huibo Wang   +12 more
wiley   +1 more source

<i>Aeromonas piscicola</i> in Chilean <i>Salmon</i> Farming: Genomic Insights, Phenotypic Traits, Virulence and Field Immune Response. [PDF]

Pathogens
Mancilla M, Ojeda A, Yuivar Y, Grandón M, Valderrama S, Oyarzún M, Grothusen H, Ibarra P, Bustos P.   +8 more
europepmc   +1 more source

Blue Light Receptor PHR2‐Mediated Spectrum Antiviral Immunity

Advanced Science, EarlyView.
Blue light suppresses RBSDV through the blue‐light receptor ZmPHR2, which interacts with ZmISP in chloroplasts to trigger ROS burst and antiviral defense. The viral effector P6 enhances ZmPHR2–ZmISP interaction, alters their distribution, and suppresses ROS.
Runyi Chen, Yuxin Tai, Xinyu Wang, Chunhua Mu, Xia Liu, Gongjian Li, Jiayi Liu, Xin Lu, Duo Shi, Zhiqiang Zhou, Jienan Han, Zhuanfang Hao, Mingshun Li, Degui Zhang, Hongjun Yong, Zhennan Xu, Jianfeng Weng, Xinhai Li   +17 more
wiley   +1 more source

Potential candidate genes influencing meat production phenotypic traits in sheep: a review. [PDF]

Front Vet Sci
Han Y, Akhtar MF, Chen W, Liu X, Zhao M, Shi L, Khan MZ, Wang C.   +7 more
europepmc   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Investigating the role of transposable elements in shaping abdominal fat and egg production phenotypic traits in geese. [PDF]

BMC Genomics
Hu S, Luo Y, Chen Y, Wang H, Wang L, Chen Z, Ma L, Zhao X, Zhang K, Xue J, Chao W, Wu X, Xie Y, Kuang S, Wang Q, Gao G.   +15 more
europepmc   +1 more source

Determination of Gene‐Level Fitness Contributions Across the Mucin‐Utilization Network of Bacteroides thetaiotaomicron

Advanced Science, EarlyView.
Genome‐wide CRISPRi and RNA‐seq resolve how B. thetaiotaomicron converts host mucosal glycans into fitness. The study reveals a layered mucin‐utilization architecture in which capsular polysaccharides constrain surface access, extracellular CAZymes and peptidases show functional redundancy, and intracellular catabolic pathways create discrete metabolic
Kangsan Kim, Jiwon Lee, Minjeong Kang, Sung Sun Yim, Donghui Choe, Byung‐Kwan Cho   +5 more
wiley   +1 more source

Comprehensive Evaluation and DNA Fingerprints of <i>Liriodendron</i> Germplasm Accessions Based on Phenotypic Traits and SNP Markers. [PDF]

Plants (Basel)
Yuan H, Zhao T, Liu X, Cheng Y, Zhang F, Chen X, Li H.   +6 more
europepmc   +1 more source

ELF5‐Mediated Enhancer–Promoter Interaction Regulates LALBA Expression in Ovine Mammary Gland

Advanced Science, EarlyView.
In the study, we systematically investigate the epigenetic mechanisms underlying lactation traits in sheep by integrating transcriptomic, chromatin accessibility, histone modification, and functional analyses. We identify a super‐enhancer at the LALBA locus and demonstrate that enhancer E4 functions as its core regulatory element.
Xinmiao Wu, Jiqing Wang, Zhiyun Hao, Mingna Li, Huimin Zhen, Yuan Liu, Guoyong Zhao, Chunyan Ren, Xuelan Zhou, Haixiong Hu, Mingjie Li, Nan Shi   +11 more
wiley   +1 more source

Exploring Genomic Variations and Phenotypic Traits of <i>Chrysodeixis includens</i> Nucleopolyhedrovirus Isolates to Improve Soybean Pest Control. [PDF]

Viruses
Andrade LA, Sosa-Gómez DR, Sihler W, Ribeiro BM, Souza ML, Lopes RB, Ardisson-Araújo DMP.   +6 more
europepmc   +1 more source