Results 181 to 190 of about 225,833 (307)

A modeling of complex trait phenotypic variance determinants

PNAS Nexus
Abstract Studies have now shown that the heritability of some complex traits, such as human height, can be virtually fully captured via potential use of sufficiently powered approaches that can characterize the associated collective common- and rare-variant additive genetic architecture.
openaire   +2 more sources

The Spatiotemporal Genetic Architecture of Seed Vigor in Upland Cotton

Advanced Science, EarlyView.
Leveraging the semi‐automated SeedRanger platform, we profiled the germination kinetics of 356 cotton accessions at a 30‐min interval. This high‐throughput phenomic approach delineated a temporal genetic network comprising 541 stage‐specific loci. Crucially, functional validation identified FLA2 as a pivotal, auxin‐modulated regulator that orchestrates
Luyao Wang, Jie Dai, Ting Zhao, Shengjun Zhao, Hongyu Wu, Jiaying Pan, Yupeng Hao, Ke Nie, Li Yu, Yumeng Zhu, Xiangyi Zhao, Kai Huang, Mengke Zhang, Yongyan Zhao, Yaping Jiang, Siyuan Wang, Yiling Pan, Yubing Chen, Yilai Lin, Wanghong Shi, Yayuan Deng, Jin Han, Jie Li, Xuan Long, Junbin Wang, Zhiyuan Zhang, Zegang Han, Zhanfeng Si, Lei Ju, Jun Li, Tianzhen Zhang, Ji Zhou, Xueying Guan   +32 more
wiley   +1 more source

From Beauty to Protection: How Phenotypic Traits Influence Conservation Perceptions of Freshwater Fish. [PDF]

Animals (Basel)
Fančovičová J, Todáková S, Prokop P.   +2 more
europepmc   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Genetic diversity analysis of angled luffa germplasm resources based on phenotypic traits and resequencing data. [PDF]

Front Plant Sci
Zeng Z, Zhang L, Guo Y, Li Y, Chen Q, Song H, Deng J, Sun X, Su G, He X, Kang D, Chen Z.   +11 more
europepmc   +1 more source

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

Advanced Science, EarlyView.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu   +8 more
wiley   +1 more source

Genome-wide modelling of plant transcription factor binding captures regulatory variants associated with phenotypic traits. [PDF]

Nat Commun
Peleke FF, Zumkeller SM, Schirmer D, Schmitz G, Hartwig T, Engelhorn J, Weizel S, Schmitt AO, Jores T, Szymański J.   +9 more
europepmc   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Linking Proteomes to Phenotypic Traits [PDF]

Proteins, as the main functional molecules of the cell, play a critical role in shaping phenotypic traits. This thesis investigates the application of proteomics data, obtained via LC-MS/MS, to understand the link be- tween protein expression and ...
Jelínek, Tomáš
core  

Exploiting predictive metabolomics of pearl millet phenotypic traits using untargeted profiling across a Brazilian germplasm panel. [PDF]

Metabolomics
Pinheiro Costa Pimentel M, Martins Abdão Dos Passos A, Prigent S, Cassan C, Dessaune Tardin F, Simões Larraz Ferreira M, Pétriacq P, Barros Santos MC.   +7 more
europepmc   +1 more source