Results 151 to 160 of about 1,168,358 (338)

Acute Induced Pressure Overload Rapidly Incites Thoracic Aortic Aneurysmal Smooth Muscle Cell Phenotype [PDF]

, 2022
Albert J. Pedroza, Rohan Shad, Alex R. Dalal, Nobu Yokoyama, Ken Nakamura, William Hiesinger, Michael P. Fischbein   +6 more
openalex   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

β-1,4-Galactosyltransferase III Enhances Invasive Phenotypes Via β1-Integrin and Predicts Poor Prognosis in Neuroblastoma [PDF]

, 2013
Hsiu‐Hao Chang, Chia‐Hua Chen, Chih-Hsing Chou, Yung‐Feng Liao, Miao-Juei Huang, Ya-Hsin Chen, Wei-Jen Wang, John Huang, Ji‐Shiang Hung, Wan‐Ling Ho, Yung‐Ming Jeng, Mei‐Ieng Che, Hsinyu Lee, Meng‐Yao Lu, Yung‐Li Yang, Shiann‐Tarng Jou, Dong‐Tsamn Lin, Kai‐Hsin Lin, Wen‐Ming Hsu, Min‐Chuan Huang   +19 more
openalex   +1 more source

Phenotyping sleep [PDF]

Journal of Sleep Research, 2011
openaire   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Non–Small Cell Lung Cancer Radiogenomics Map Identifies Relationships between Molecular and Imaging Phenotypes with Prognostic Implications

, 2017
Mu Zhou, Ann N. Leung, Sebastian Echegaray, Andrew J. Gentles, Joseph B. Shrager, Kristin C. Jensen, Gerald J. Berry, Sylvia K. Plevritis, Daniel L. Rubin, Sandy Napel, Olivier Gevaert   +10 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Revealing the clinical phenotype of atypical neuronal ceroid lipofuscinosis type 2 disease: Insights from the largest cohort in the world [PDF]

, 2020
Charles Marques Lourenço, André Luiz Santos Pessoa, Carmen Curiati Mendes, Carolina Rivera‐Nieto, Diane Vergara, M. Troncoso, Emily Gardner, Francisca Mallorens, Lina Marcela Tavera, Luis Arturo Lizcano, Nora Atanacio, Norberto Guelbert, Norma Spécola, Nury Mancilla, Carolina Fischinger Moura de Souza, Sara Mole   +15 more
openalex   +1 more source

Validation of a computational phenotype for finding patients eligible for genetic testing for pathogenic PTEN variants across three centers [PDF]

, 2022
Cartik R. Kothari, Siddharth Srivastava, Youssef A. Kousa, Rima Izem, Marcin Gierdalski, Dong‐Kyu Kim, Amy B. Good, Kira A. Dies, Gregory Geisel, Hiroki Morizono, Vittorio Gallo, Scott L. Pomeroy, Gwenn A. Garden, Lisa M. Guay‐Woodford, Mustafa Şahin, Paul Avillach   +15 more
openalex   +1 more source

Intricate relationships between frailty and diabetes: where do we go from here?

The Lancet. Healthy Longevity, 2020
Gloria A Aguayo, Guy Fagherazzi
doaj   +1 more source