Root phenotyping of NS sunflower
, 2018 Sunflower breeding, in the past decades, had lead to significant improvements in sunflower yield, pest resistance, and altered oil composition; however breeding is oriented towards analysis and improvement of above-ground parts, while root development ...
Terzic, Sreten +7 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
FIELD PHENOTYPING: REMOTE AND PROXIMAL HIGH-THROUGHPUT PLATFORMS IN SOUTHERN ITALY
High-throughput field phenotyping offers dramatic improvements in the determination of key crop traits, enabling the collection of objective, repeatable and non-destructive measurements through the growing ...
FRANCESCO CELLINI +9 more
core
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Advanced imaging tools for plant phenotyping
, 2017 High throughput plant phenotyping, also called plant phenomics, is an emerging and fast growing research field that aims to bridge the existing gap between genomics and plant breeding, by solving the so-called phenotyping bottleneck.
MENESATTI, P. +3 more
core
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Advances in root phenotyping: high-throughput imaging, computational tools, and integrative approaches for crop improvement. [PDF]
J Exp BotIm G, Baek J, Kim J, Kim SL.
europepmc +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Adherence and Acceptability of Smartphone- and Wearable-Based Digital Phenotyping in Patients With First-Episode Psychosis: Observance et acceptabilité du phénotypage numérique fondé sur les téléphones intelligents et les objets personnels connectés chez les patients présentant un premier épisode de psychose. [PDF]
Can J PsychiatryYang L +8 more
europepmc +1 more source