Results 181 to 190 of about 1,168,358 (338)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Resting-State Functional Connectivity of the Central Executive Network Moderates the Relationship Between Neighborhood Violence and Proinflammatory Phenotype in Children

, 2021
Gregory E. Miller, Edith Chen, Eric D. Finegood, Phoebe H. Lam, Rachel Weissman-Tsukamoto, Adam K.K. Leigh, Lauren Hoffer, Ann Carroll, Gene H. Brody, Todd B. Parrish, Robin Nusslock   +10 more
openalex   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

PhenoFit: a framework for determining computable phenotyping algorithm fitness for purpose and reuse. [PDF]

J Am Med Inform Assoc
Wiley LK, Rasmussen LV, Levinson RT, Malinowski J, Manemann SM, Wilson MP, Chapman M, Pacheco JA, Walunas TL, Starren JB, Bielinski SJ, Richesson RL.   +11 more
europepmc   +1 more source

Growth Factor Regulation of Corneal Keratocyte Mechanical Phenotypes in 3-D Collagen Matrices

, 2012
Neema Lakshman, W. Matthew Petroll
openalex   +2 more sources

Transcriptional response of human articular chondrocytes treated with fibronectin fragments: an in vitro model of the osteoarthritis phenotype

, 2020
Kathleen S Metz Reed, Veronica Ulici, James Kim, Susan Chubinskaya, Richard F. Loeser, Douglas H. Phanstiel   +5 more
openalex   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Characterizing cardiac phenotype in Friedreich's ataxia: The CARFA study

, 2021
L. Legrand, Jonathan W. Weinsaft, Françoise Pousset, Claire Ewenczyk, Perrine Charles, Stéphane Hatem, Anna Heinzmann, Marie Biet, Alexandra Dürr, Alban Redheuil   +9 more
openalex   +2 more sources

Phenotype matters [PDF]

Nature Genetics, 2004
openaire   +2 more sources