Results 231 to 240 of about 1,264,213 (379)
Transport and metabolism of sarcosine in hypersarcosinemic and normal phenotypes [PDF]
, 1971 Francis H. Glorieux +3 more
openalex +1 more source
A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications
Molecular Oncology, EarlyView.Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker +3 more
wiley +1 more source
Cytotoxic T cells: Lyt phenotype and blocking of killing activity by Lyt antisera [PDF]
, 1979 Eiichi Nakayama +4 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Harnessing digital phenotyping to advance university student mental health (Brightline) in Singapore: study protocol for a prospective observational study. [PDF]
BMJ OpenIto S +12 more
europepmc +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Multi-domain rule-based phenotyping algorithms enable improved GWAS signal. [PDF]
NPJ Digit MedNewbury A, Elhussein A, Gürsoy G.
europepmc +1 more source