Results 41 to 50 of about 1,049 (182)

Zeaxanthin Mitigates Hydroxychloroquine‐Induced Retinal Toxicity and Metabolic Reprogramming in ARPE‐19 Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 7, July 2026.
HCQ exposure disrupts lysosomal acidification, increases ROS production, impairs mitochondrial function, and induces metabolic reprogramming in ARPE‐19 cells, resulting in increased necrosis and reduced cell viability. ZEA treatment significantly reduced oxidative stress, stabilized mitochondrial membrane potential, improved metabolic homeostasis, and ...
Münire Berna Asal Altıparmak, Emine Merve Yıldırım, Ozan Kaplan, Emine Koç, Açelya Erikçi, Mustafa Çelebier, Tuba Tüylü Küçükkılınç, Gülberk Uçar   +7 more
wiley   +1 more source

Long‐Term Efficacy and Safety of Glycerol Phenylbutyrate in Japanese Patients With Urea Cycle Disorders: Results From a Phase 3 Switch‐Over and 12‐Month Extension Study

JIMD Reports, Volume 67, Issue 4, July 2026.
ABSTRACT Sodium phenylbutyrate (NaPBA) is used for nitrogen scavenging in urea cycle disorders (UCDs), but its volume, palatability, and sodium load affect adherence and ammonia control. Glycerol phenylbutyrate (GPB) offers an alternative option with demonstrated improvements in metabolic control and palatability.
Yoichi Wada, Mahoko Furujo, Kenichi Kashimada, Takashi Hamazaki, Hiromi Nyuzuki, Keiko Ichimoto, Toshihiko Kakiuchi, Shirou Matsumoto, Yoriko Watanabe, Chiho Ono, Takako Shimizu, Hiroiku Furukawa, Kimitoshi Nakamura   +12 more
wiley   +1 more source

Long‐Term Follow‐Up of Patients With Mitochondrial Carbonic Anhydrase VA Deficiency. A Case Report and Literature Review

JIMD Reports, Volume 67, Issue 4, July 2026.
ABSTRACT Mitochondrial carbonic anhydrase VA (CA‐VA) deficiency is a rare inherited metabolic disorder caused by biallelic variants of the CA5A gene. It presents with hyperammonemia, lactic acidosis, and ketonuria, with or without hypoglycemia. We report the long‐term follow‐up of the first two reported cases of CA‐VA deficiency: a 16‐year‐old female ...
Shaymaa Shurrab, Amira Mobarak, Gabriella Horvath, Sylvia Stocker‐Ipsiroglu, Clara van Karnebeek, Ramona Salvarinova‐Zivkovic   +5 more
wiley   +1 more source

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, Volume 46, Issue 4, Page 1111-1151, July 2026.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source

The Synthesis of Certain Alkyl Alpha-(2-Dialkylam Inoalkoxy)Phenylacetates

, 1947
This thesis describes the procedures used in preparation of the derivatives of certain alkyl phenylacetates and the necessary intermediate compounds. Compounds resembling the structure of Benadryl were prepared in this study in the hope that at least one
Mark, Roscoe Dewey
core  

Alkyl Arylacetates in Cascade Reactions with 2‐Cyanobenzaldehydes for the Synthesis of 3‐Substituted Isoindolinones

European Journal of Organic Chemistry, Volume 29, Issue 24, 23 June 2026.
Effective synthesis of 3‐substituted isoindolinones is possible through novel cascade reactions of alkyl arylacetates with 2‐cyanobenzaldehydes under mild, basic conditions. Herein we report the use of alkyl arylacetates as pro‐nucleophiles in cascade reactions with 2‐cyanobenzaldehydes leading to the formation of novel 3‐substituted isoindolinones, a ...
Antonia Di Mola, Prabaharan Thiruvengetam, Alessandra Forlenza, Armin R. Ofial, Antonio Massa   +4 more
wiley   +1 more source

A versatile synthesis of cyclic dipeptides using the stepwise construction of the piperazine-2,5-dione ring from simple precursors: synthetic sequence and the structure of a representative product, (3RS)-4-(2-allyl-3,5-dimethylphenyl)-1-benzyl-3-phenylpiperazine-2,5-dione

, 2018
A versatile synthesis of multiply substituted cyclic dipeptides has been designed, based on the stepwise construction of the piperazine-2,5-dione ring using molecular fragments from four different precursor molecules.
Christopher Glidewell, Lina M. Acosta Quintero, Alirio Palma, Justo Cobo   +3 more
core   +1 more source

Base- and sulfur-promoted oxidative lactonization of chalcone-acetate Michael adducts: access to pyran-2-ones

A cost-effective, practical, straightforward and scalable synthesis of α-pyrones via base- and sulfur-promoted annulation of phenylacetates and chalcones is reported.
Nguyen, T.B., Retailleau, P., Nguyen, D.T., Tran, H.A., Mac, D.H., Nguyen, C.N., Nguyen, T.T.T.   +6 more
core   +1 more source

Quinoxaline chemistry: Part 14: 4-(2-Quinoxalylamino)-phenylacetates and 4-(2-quinoxalylamino)-phenylacetyl-_L -glutamates as analogues-homologues of classical antifolate agents: synthesis and evaluation of in vitro anticancer activity

, 2002
Among a new series of 26 4-(3-substituted-2-quinoxalylamino)phenylacetates and 4-(3-substituted-2-quinoxalylamino)phenylacetyl-L -glutamates, eight were selected at NCI for evaluation of their in vitro anticancer activity.
Paglietti, Giuseppe, Loriga, Mario, Piras, Sandra   +2 more
core  

Conformational analysis of some: α-ethylthio-, α- ethylsulfinyl-, α-ethylsulfonyl-, p-substituted phenylacetates; 1-(5-substituted thiophen-2-yl)-2-(ethylthio)ethanone and 1-(5-substituted furan-2-yl)-2- (ethylthio)ethanone; 1-(5-substituted thiophen-2-yl)-2-(bromo)ethanone

, 2014
A presente tese trata da síntese e análise conformacional dos: α-etiltioacetatos de fenila p-substituídos (Série I), α-etilsulfinilacetatos de fenila p-substituídos (Série II), α- etilsulfonilacetatos de fenila p-substituídos (Série III ...
Daniel Nopper Silva Rodrigues, Rodrigues, Daniel Nopper Silva   +1 more
core   +1 more source