Results 21 to 30 of about 949 (140)
Construction of Chronic Kidney Disease Mouse Model Induced by Diets With Different Adenine Content
Food Safety and Health, Volume 4, Issue 3, Page 684-696, July 2026.By administering a 4 weeks adenine diet to C57BL/6J mice, we identified 0.2% adenine in purified feed as the optimal chronic kidney disease model. This model induces severe renal damage, gut dysbiosis, uremic toxin accumulation, and CKD mineral bone disorder, providing a clinically relevant platform for mechanistic and therapeutic studies.
Wanjun Liao +8 more
wiley +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 7, July 2026.HCQ exposure disrupts lysosomal acidification, increases ROS production, impairs mitochondrial function, and induces metabolic reprogramming in ARPE‐19 cells, resulting in increased necrosis and reduced cell viability. ZEA treatment significantly reduced oxidative stress, stabilized mitochondrial membrane potential, improved metabolic homeostasis, and ...
Münire Berna Asal Altıparmak +7 more
wiley +1 more source
JIMD Reports, Volume 67, Issue 4, July 2026.ABSTRACT Sodium phenylbutyrate (NaPBA) is used for nitrogen scavenging in urea cycle disorders (UCDs), but its volume, palatability, and sodium load affect adherence and ammonia control. Glycerol phenylbutyrate (GPB) offers an alternative option with demonstrated improvements in metabolic control and palatability.
Yoichi Wada +12 more
wiley +1 more source
JIMD Reports, Volume 67, Issue 4, July 2026.ABSTRACT Mitochondrial carbonic anhydrase VA (CA‐VA) deficiency is a rare inherited metabolic disorder caused by biallelic variants of the CA5A gene. It presents with hyperammonemia, lactic acidosis, and ketonuria, with or without hypoglycemia. We report the long‐term follow‐up of the first two reported cases of CA‐VA deficiency: a 16‐year‐old female ...
Shaymaa Shurrab +5 more
wiley +1 more source
Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?
Medicinal Research Reviews, Volume 46, Issue 4, Page 1111-1151, July 2026.ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca +6 more
wiley +1 more source
European Journal of Organic Chemistry, Volume 29, Issue 24, 23 June 2026.Effective synthesis of 3‐substituted isoindolinones is possible through novel cascade reactions of alkyl arylacetates with 2‐cyanobenzaldehydes under mild, basic conditions. Herein we report the use of alkyl arylacetates as pro‐nucleophiles in cascade reactions with 2‐cyanobenzaldehydes leading to the formation of novel 3‐substituted isoindolinones, a ...
Antonia Di Mola +4 more
wiley +1 more source
Advanced Science, Volume 13, Issue 34, 19 June 2026.In anaerobic bacteria, tyrosine serves as an electron donor in the oxidative Stickland fermentation branch, generating p‐hydroxyphenylacetate, ATP and reduced ferredoxin for decarboxylation into p‐cresol. ABSTRACT The phenolic metabolite p‐cresol is a byproduct of tyrosine fermentation by certain strictly anaerobic bacteria, including the human gut ...
Li Jiang +15 more
wiley +1 more source
Metabolic Fingerprinting of Urine Reveals Metabolite Changes in Women With Breast Cancer
Cancer Medicine, Volume 15, Issue 6, June 2026.This study uses metabolomics to compare urine, plasma and serum metabolite profiles across breast cancer, benign breast disease, symptomatic and healthy controls. Significant metabolic differences—especially in amino acids—were found between BC and other groups, with moderate correlations across biofluids, suggesting potential for non‐invasive BC ...
Nur Aimi Aliah Zainurin +9 more
wiley +1 more source
PFAS properties and destruction methods: A focus on enzymatic degradation
Journal of Chemical Technology &Biotechnology, Volume 101, Issue 6, Page 1126-1152, June 2026.Abstract Per‐ and polyfluoroalkyl substances (PFAS) are known as ‘forever’ chemicals and have lasting detrimental impact on the environment and living organisms. To understand PFAS molecules better, this review begins with an overview of PFAS definition, classifications and applications, and then provides a comprehensive summary and critical analysis ...
Guobin Liang, Hua Zhao
wiley +1 more source
Early prediction of bronchopulmonary dysplasia by urinary metabolomics: a case-control study. [PDF]
ThoraxBonadies L +8 more
europepmc +1 more source