Results 31 to 40 of about 48,307 (173)

Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis

European Journal of Organic Chemistry, EarlyView.
In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley   +1 more source

Rapid Synthesis of Weinreb Amides via Titanium‐Mediated Direct Amidation at Room Temperature

European Journal of Organic Chemistry, EarlyView.
Rapid titanium‐mediated direct amidation enables the room‐temperature synthesis of Weinreb amides directly from carboxylic acids under mild conditions. The operationally simple protocol delivers a broad substrate scope in good to excellent yields, including challenging fluorinated substrates, without the need for conventional coupling reagents ...
Aman G. Singh, Henry J. Hamann, P. Veeraraghavan Ramachandran   +2 more
wiley   +1 more source

Uremic toxins inhibit transport by breast cancer resistance protein and multidrug resistance protein 4 at clinically relevant concentrations.

PLoS ONE, 2011
During chronic kidney disease (CKD), there is a progressive accumulation of toxic solutes due to inadequate renal clearance. Here, the interaction between uremic toxins and two important efflux pumps, viz. multidrug resistance protein 4 (MRP4) and breast
Henricus A M Mutsaers, Lambertus P van den Heuvel, Lauke H J Ringens, Anita C A Dankers, Frans G M Russel, Jack F M Wetzels, Joost G Hoenderop, Rosalinde Masereeuw   +7 more
doaj   +1 more source

Gut microbiota‐mediated immune and metabolic dysregulation in coronary artery disease progression and prognosis

iMeta, EarlyView.
The gut microbiota has emerged as a metabolically active endocrine‐like organ with a crucial role in coronary artery disease (CAD), yet its contribution to adverse clinical outcomes remains incompletely understood. In this prospective cohort of 319 participants, we integrated metagenomic and metabolomic profiling with longitudinal follow‐up over a ...
Honghong Liu, Siqin Feng, Lifeng Liang, Muyun Tang, Yifei Wang, Yiyang Wang, Zhiyu Zhang, Haiping Xing, Chenhong Zhang, Ran Tian, Shuyang Zhang   +10 more
wiley   +1 more source

Clinical study on gut microbiota and metabolomic characteristics in septic patients

Zhongguo Linchuang Yixue
ObjectiveTo explore the dynamic changes of gut microbiota metabolites in septic patients following admission, as well as the correlations between these metabolites, the gut microbiota, and the prognosis of septic patients.
Xiangyu Long, Zhenju Song, Mian Shao
doaj   +1 more source

The Microbiome–Metabolome Response in the Colon of Piglets Under the Status of Weaning Stress

Frontiers in Microbiology, 2020
Weaning is stressful for piglets involving nutritional, physiological, and psychological challenges, leading to an increase in the secretion of cortisol, changes in gut microbiome and metabolites, whereas the underlying relationships remain unclear.
Xueyuan Jiang, Naisheng Lu, Haichao Zhao, Haichao Zhao, Hao Yuan, Dong Xia, Hulong Lei   +6 more
doaj   +1 more source

An Historical Review of Phenylacetic Acid

Plant and Cell Physiology, 2019
Plant hormone biology is an ever-evolving field and as such, novel avenues of research must always be sought. Technological and theoretical advancement can also allow for previously dismissed research to yield equally interesting insights into processes now that they are better understood.
openaire   +2 more sources

A Comprehensive Study of Bidirectional Interactions Between the Human Microbiome and Blood Malignancies and Hematologic Conditions: Focus on Novel Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Microbiota‐targeted therapeutic strategies in hematological disorders. aHSCT: Transplanted immune cells from the donor may attack the recipient's tissues, especially when damage to the intestinal epithelium disrupts the gut microbiota, contributing to GVHD. Maintaining a balanced gut microbiota that supports immune regulation helps reduce GVHD risk and
Alireza Molajafari, Hadi Sedigh Ebrahim‐Saraie, Majid Taati Moghadam, Meysam Hasannejad‐Bibalan   +3 more
wiley   +1 more source

Domestication‐associated reduction of methyl salicylate in tomato root and its significance for resistance to root‐knot nematode

New Phytologist, EarlyView.
Root volatile profiling reveals domestication‐associated variation in methyl salicylate (MeSA) accumulation in tomato. Summary Methyl salicylate (MeSA) plays diverse roles in the aerial parts of plants. By contrast, its biosynthesis and function in roots remain poorly understood.
Weijiao Wang, Manoj Sapkota, Sobhan Bahrami Zadegan, Tarek Hewezi, Esther van der Knaap, Feng Chen   +5 more
wiley   +1 more source

Chemogenetic activation of mammalian brain neurons expressing insect Ionotropic Receptors by systemic ligand precursor administration

Communications Biology
Chemogenetic approaches employing ligand-gated ion channels are advantageous regarding manipulation of target neuronal population functions independently of endogenous second messenger pathways.
Yoshio Iguchi, Ryoji Fukabori, Shigeki Kato, Kazumi Takahashi, Satoshi Eifuku, Yuko Maejima, Kenju Shimomura, Hiroshi Mizuma, Aya Mawatari, Hisashi Doi, Yilong Cui, Hirotaka Onoe, Keigo Hikishima, Makoto Osanai, Takuma Nishijo, Toshihiko Momiyama, Richard Benton, Kazuto Kobayashi   +17 more
doaj   +1 more source