The Borrelia afzelii outer membrane protein BAPKO_0422 binds human Factor-H and is predicted to form a membrane-spanning beta-barrel [PDF]
The deep evolutionary history of the Spirochetes places their branch point early in the evolution of the diderms, before the divergence of the present day Proteobacteria.
Adam Dyer +76 more
core +1 more source
Wet dust removal systems are an effective design for preventing aluminum dust explosion in the process of metal polishing. However, wet dust removal systems pose hydrogen fire and explosion risks because aluminum dust can react with water to produce ...
Xin Zheng +4 more
semanticscholar +1 more source
pH‐Tunable Material Properties of Glycine‐Rich Condensates from Tick Bioadhesive
This work studies the influence of pH on the phase separation behavior of a disordered glycine‐rich protein found in tick bioadhesive. The results show profound impact on the propensity of coacervation, condensate microstructure and viscosity, amphiphilicity of the peptides, and effective encapsulation of therapeutic molecules.
Manali Nandy +5 more
wiley +1 more source
Peptide Sequencing With Single Acid Resolution Using a Sub‐Nanometer Diameter Pore
To sequence a single molecule of Aβ1−42–sodium dodecyl sulfate (SDS), the aggregate is forced through a sub‐nanopore 0.4 nm in diameter spanning a 4.0 nm thick membrane. The figure is a visual molecular dynamics (VMD) snapshot depicting the translocation of Aβ1−42–SDS through the pore; only the peptide, the SDS, the Na+ (yellow/green) and Cl− (cyan ...
Apurba Paul +8 more
wiley +1 more source
Phenylalanine-Based AMPA Receptor Antagonist as the Anticonvulsant Agent with Neuroprotective Activity—In Vitro and In Vivo Studies [PDF]
Gniewomir Latacz +6 more
openalex +1 more source
Direct evidence for a phenylalanine site in the regulatory domain of phenylalanine hydroxylase [PDF]
The hydroxylation of phenylalanine to tyrosine by the liver enzyme phenylalanine hydroxylase is regulated by the level of phenylalanine. Whether there is a distinct allosteric binding site for phenylalanine outside of the active site has been unclear. The enzyme contains an N-terminal regulatory domain that extends through Thr117. The regulatory domain
Jun, Li +4 more
openaire +2 more sources
Inspired by the skin‐toughening mechanism of marine sponges, an ion‐orchestrated structural engineering strategy is proposed to regulate the surface microstructure of hydrogel coatings, enabling the in situ formation of a robust armor layer that enhances mechanical integrity and provides multifunctional protection by suppressing fouling attachment and ...
Wenshuai Yang +11 more
wiley +1 more source
Excess accumulation of phenylalanine is the characteristic of untreated Phenylketonuria (PKU), a well-known genetic abnormality, which triggers several neurological, physical and developmental severities.
B. Anand +3 more
semanticscholar +1 more source
Proteins, Processing, and Properties of Adhesive Fluid Condensates Purified from Mussels
Mussels exhibit an unmatched proficiency for adhering to wet surfaces in salty environments—a remarkable ability that could inspire new biomedical and technical glues. The fluid protein condensates used to form the underwater mussel glue are extracted, reconstituted and characterized with advanced spectroscopy and nanomechanical analysis, revealing ...
Mathieu D. Rivard +8 more
wiley +1 more source
An electrostatic interaction between TEA and an introduced pore aromatic drives spring-in-the-door inactivation in Shaker potassium channels [PDF]
Slow inactivation of Kv1 channels involves conformational changes near the selectivity filter. We examine such changes in Shaker channels lacking fast inactivation by considering the consequences of mutating two residues, T449 just external to the ...
Ader +39 more
core +2 more sources

