Synthesis of α‐Pentafluorosulfanylated‐β2,3‐Amino Esters
De novo α‐SF5‐β2,3‐amino esters are now accessible through a straightforward aza‐Michael reaction using a series of newly developed (E)‐α‐SF5‐α,β‐unsaturated esters. Two new, highly functionalized, contiguous tertiary stereocenters are formed with diastereodivergence governed by the choice of solvent and/or base.
Thi Mo Nguyen +5 more
wiley +1 more source
Synthesis of
Fabio Parmeggiani +4 more
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Chemical Methods for Peptide and Protein Backbone Cleavage
Protein cleavage plays essential roles in biology and is powerful for protein manipulation and functionalization as well as in recombinant expression and purification. Here, the historical background and most recent examples of chemical methods for protein and peptide backbone cleavage are discussed (part of the figure was generated in BioRender).
Miguel Angel Alena‐Rodriguez +1 more
wiley +1 more source
A Thin Film Micro-Extraction Based Salivary Metabolomics and Chemometric Strategy for Rapid Lung Cancer Diagnosis. [PDF]
Erbas İ +10 more
europepmc +1 more source
Intramolecular N···F Pnictogen Bond Mitigates the Explosive Behavior of Azido‐L‐Phenylalanines
An intramolecular N···F pnictogen bond is the key for the chemical stabilization of the fluorinated azido‐L‐phenylalanines, mitigating the risk of explosion and thus facilitating the handling and storage of these materials. Organic azides are versatile intermediates but are plagued by intrinsic instability and potential explosiveness. Here, it is shown
Andrea Pizzi +5 more
wiley +1 more source
Population genetics of hyperphenylalaninaemia resulting from phenylalanine hydroxylase deficiency in Portugal. [PDF]
Isabel Rivera +4 more
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Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati +4 more
wiley +1 more source
Hydrophobic and Electrostatic Sequence Patterning Directs Hierarchical Assembly of Phenylalanine-Rich Oligopeptides. [PDF]
Leśniewski M +5 more
europepmc +1 more source

