Results 171 to 180 of about 425,330 (380)

DFT‐Guided Design of a Multi‐Enzyme Mimetic High‐Entropy Nanozyme for Cascaded Glutathione Detection and Point‐of‐Care Testing

Advanced Science, EarlyView.
Guided by density functional theory (DFT) calculations, a MnCoNiCuZnFe‐based Prussian blue analog (HEO) is screened out. It exhibits superior peroxidase (POD)‐like activity compared to noble metal‐incorporated high‐entropy nanozymes together with excellent oxidase (OXD) and glutathione oxidase (GSHOx)‐like activities.
Hua Lin, Li Ke, Shuran Wang, Ruoke Li, Shengmin Zhou, Yueling Liu, Huan Pang   +6 more
wiley   +1 more source

Plant Phenylalanine/Tyrosine Ammonia-lyases.

Trends in Plant Science, 2019
J. Barros, R. Dixon
semanticscholar   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Effects of feeding tyrosine or phenylalanine on the accumulation of polyphenols in Coleus Blumei in Vivo and in Vitro .

, 2019
Hala M. Musbah, Kadhim M. Ibrahim, Kadhim M. Ibrahim   +2 more
openalex   +2 more sources

Amino Acid Isomerization in the Production of l-Phenylalanine from d-Phenylalanine by Bacteria1 [PDF]

, 1965
Ichiro Chibata, Tetsuya Tosa, Ryujiro Sano   +2 more
openalex   +1 more source

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

The effects of hyperphenylalaninaemia on the concentrations of aminoacyl-transfer ribonucleic acid in vivo. A mechanism for the inhibition of neural protein synthesis by phenylalanine [PDF]

, 1977
Joseph V. Hughes, Terry C. Johnson
openalex   +1 more source

SERS‐AI‐LUA‐Driven Salivary Diagnosis of Head and Neck Cancer Using Graphene‐Assisted Plasmonic Nanocorals

Advanced Science, EarlyView.
The developed graphene‐assisted plasmonic nanocoral platform enables sensitive, label‐free surface‐enhanced Raman scattering analysis of salivary metabolites for head and neck cancer (HNC) detection. When combined with machine learning classification and nonnegative least squares‐based spectral deconvolution, this approach achieves 98% diagnostic ...
Hyo Jeong Seo, Boyou Heo, Jun‐Yeong Yang, Rowoon Park, Sung‐Gyu Park, Jiyoung Yeo, So Hee Park, Chan Kwon Jung, Min‐Young Lee, Jooin Bang, Jun‐Ook Park, Ho Sang Jung   +11 more
wiley   +1 more source

Utilizing systematic Mendelian randomization to identify potential therapeutic targets for mania

Frontiers in Psychiatry
BackgroundMania has caused incalculable economic losses for patients, their families, and even society, but there is currently no effective treatment plan for this disease without side effects.MethodsUsing bioinformatics and Mendelian randomization ...
Fang-Biao Xu, Fang-Biao Xu, Sen Hu, Jing-Jing Wang, Xin-Zhi Wang, Xin-Zhi Wang   +5 more
doaj   +1 more source

GSH as an A‐A Type Allosteric Activator of PKM2: Modulating Cancer Cell Homeostasis and Ferroptosis Susceptibility

Advanced Science, EarlyView.
Glutathione (GSH) defines oxidative balance, but can it directly tune central metabolism? The research reveals that GSH binds and potently activates pyruvate kniase M2 (PKM2), rewiring glycolysis and dictating ferroptosis sensitivity. Combining GSH depletion with PKM2 activation triggers mitochondrial damage and lipid peroxidation, profoundly ...
Tsan‐Jan Chen, Chi‐Jen Lo, Meng‐Jen Wu, Wei Yang Sit, Hsin‐Yu Hsu, Yi‐Cheng Huang, Chien‐Hung Lu, Yu‐Lun Chen, Wei‐Kai Fang, Shan‐Min Yang, Pei‐Lien Chen, Tokuko Haraguchi, Yasushi Hiraoka, Chun‐Yu Lin, Mei‐Ling Cheng, Muh‐Hwa Yang, Hsing‐Jien Kung, Wen‐Ching Wang   +17 more
wiley   +1 more source