Results 241 to 250 of about 390,444 (399)

N-Lactoyl Amino Acids: Emerging Biomarkers in Metabolism and Disease. [PDF]

open access: yesDiabetes Metab Res Rev
Naja K   +4 more
europepmc   +1 more source

Internal Ubiquitin Electrophiles for Covalent Trapping and Inhibition of Deubiquitinases

open access: yesChemBioChem, Accepted Article.
The ubiquitin (Ub) system governs vital cellular processes in eukaryotic biology through an intricate network of Ub‐protein interactions. While semisynthetic C‐terminal Ub electrophiles (UbEs) are widely used to study Ub transfer and deubiquitinase (Dub) activity, they are limited to probing the active site while leaving other functionally important ...
Chittaranjan Das   +7 more
wiley   +1 more source

Bioactivity profiles of progressively ring‐fluorinated cyclohexyl motifs in the WKYMVm peptide as formylpeptide FPR2 agonists and in keto‐piperazines as anti‐trypanosome agents.

open access: yesChemBioChem, Accepted Article.
A series of all‐cis ring fluorinated cyclohexylalanines with progressively increasing levels of vicinal fluorines, as well as 4‐fluorophenylalanine and pentafluoroarylphenylalanine were introduced into the WKYMVm peptide in place of its tyrosine residue, for assays against the G‐protein coupled formylpeptide receptor, FPR2.
David O'Hagan   +6 more
wiley   +1 more source

Synthesis of Nucleoside Derivatives by Biomimetic Ester Migration

open access: yesChemBioChem, EarlyView.
In tRNA aminoacylated nucleosides represent the central transfer unit of amino acids. An occurring 2′‐3′‐transaminoacylation is biomimetically exploited to successfully synthesize nucleosidic acid esters. This approach can be further expanded on sulfonic acid esters, which has the potential of a broad range of stereo‐ and regio‐controlled modifications
Nathalie J. Kurrle   +8 more
wiley   +1 more source

Experimental Animal Models of Phenylketonuria: Pros and Cons. [PDF]

open access: yesInt J Mol Sci
Bobrova NA   +7 more
europepmc   +1 more source

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