Results 311 to 320 of about 394,077 (382)

Experimental Animal Models of Phenylketonuria: Pros and Cons. [PDF]

open access: yesInt J Mol Sci
Bobrova NA   +7 more
europepmc   +1 more source

Mild and Selective Trifluoromethylation of Peptides at Tryptophane Residues by a Water‐Soluble Copper Complex with Redox‐Active Ligands

open access: yesChemistry – A European Journal, EarlyView.
Selective functionalization of aminoacids is a key endeavor in chemical biology. Radical manifolds offer interesting possibilities but can suffer from limited control over radical processes, resulting in a lack of selectivity in product distribution.
Marie‐Julie Tilly   +9 more
wiley   +1 more source

A Short Peptide Inhibitor of Measles Virus Fusion Protein that Exhibits Passive Membrane Permeability

open access: yesChemMedChem, EarlyView.
Fusion inhibitor peptide (FIP) is a known small peptide capable of inhibiting measles virus infection. In this study, hydrogen‐to‐fluorine substitution is employed to derivatize FIP, leading to the discovery of a FIP derivative with enhanced inhibitory activity and passive membrane permeability.
Ziwei Gao   +5 more
wiley   +1 more source

Milk Protein Glycation Compromises Postprandial Lysine Bioavailability but does not Modulate Postprandial Muscle Protein Synthesis Rates In Vivo in Males: A Double-blind, Randomized Parallel Trial. [PDF]

open access: yesJ Nutr
van Lieshout GA   +9 more
europepmc   +1 more source

C1′‐Branched Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium Falciparum 6‐Oxopurine Phosphoribosyltransferase

open access: yesChemMedChem, EarlyView.
Novel C1'‐branched acyclic nucleoside phosphonates were synthesized. The compounds are inhibitors of Plasmodium falciparum and human 6‐oxopurine phosphoribosyltransferases with Ki values as low as 0.4 µM and 0.7 µM, respectively. A phosphonodiamidate prodrug exhibited IC50 = 4.3 µM against a drug‐sensitive strain of P.
Jan Frydrych   +11 more
wiley   +1 more source

Spectrum of <i>PAH</i> gene variants in Jordanian patients with phenylalanine hydroxylase deficiency. [PDF]

open access: yesBiomed Rep
Fathallah R   +6 more
europepmc   +1 more source

Identification of Urethanases for Biocatalytic Recycling of Toluene Diisocyanate‐ and Methylene Diphenyl Diisocyanate‐Based Polyurethanes

open access: yesChemSusChem, EarlyView.
Sequence similarity analysis led to the identification of novel urethanases capable of hydrolyzing industrially significant carbamates derived from chemical recycling, such as methanolysis. This allows a combined chemical and enzymatic recycling strategy, which facilitates the depolymerization of polyether‐polyurethane into dicarbamates and ultimately ...
Linda Pastor   +7 more
wiley   +1 more source

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