Results 361 to 370 of about 390,444 (399)

Phenylalanine Oligomers and Fibrils: The Mechanism of Assembly and the Importance of Tetramers and Counterions.

Journal of the American Chemical Society, 2015
Phenylalanine is the only amino acid known to self-assemble into toxic fibrillar aggregates. An elevated concentration of phenylalanine in the blood can result in Phenylketonuria, a progressive mental retardation.
Thanh D. Do, William M Kincannon, M. Bowers   +2 more
semanticscholar   +1 more source

Self-assembly of phenylalanine-based molecules.

Journal of Physical Chemistry A, 2015
Using molecular dynamics, we study the self-assembly of phenylalanine with charged end-groups at various temperatures and concentrations. As in the case of diphenylalanine, we observe the formation of nanotubes; however, phenylalanine aggregates in ...
Helen W. German, S. Uyaver, U. Hansmann
semanticscholar   +1 more source

Phenylalanine ammonia-lyase, a key component used for phenylpropanoids production by metabolic engineering

, 2015
Phenylalanine ammonia-lyase (PAL, EC 4.3.1.24) catalyzes the deamination of phenylalanine to cinnamate and ammonia, the first step of the phenylpropanoid pathway.
J. Kong
semanticscholar   +1 more source

Understanding the self-assembly of Fmoc-phenylalanine to hydrogel formation.

Soft Matter, 2015
Hydrogels of low molecular weight molecules are important in biomedical applications. Multiple factors are responsible for hydrogel formation, but their role in governing self-assembly to hydrogel formation is poorly understood.
Virender Singh, Kirti Snigdha, C. Singh, N. Sinha, A. Thakur   +4 more
semanticscholar   +1 more source

Inhibition of dihydroxyphenylalanine decarboxylase by derivatives of phenylalanine

Archives of Biochemistry and Biophysics, 1954
Abstract A series of compounds, related chemically to phenylalanine, have been examined for their action on dopa decarboxylase of pig kidney and on bacterial tyrosine decarboxylase. Some of the compounds were found to inhibit these enzymes. The relation between degree of inhibition and chemical structure of the inhibitors has been discussed ...
openaire   +3 more sources

Phenylalanine and Phenylglycine Analogues as Arginine Mimetics in Dengue Protease Inhibitors.

Journal of Medicinal Chemistry, 2015
Dengue virus is an increasingly global pathogen. One of the promising targets for antiviral drug discovery against dengue and related flaviviruses such as West Nile virus is the viral serine protease NS2B-NS3.
Lena F Weigel, Christoph Nitsche, D. Graf, R. Bartenschlager, C. Klein   +4 more
semanticscholar   +1 more source

Interaction of L-Phenylalanine with a Phospholipid Monolayer at the Water-Air Interface.

Journal of Physical Chemistry B, 2015
The interaction of L-phenylalanine with a 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) monolayer at the air-water interface was explored using a combination of experimental techniques and molecular dynamics (MD) simulations.
E. Griffith, Russell J. Perkins, D. Telesford, E. Adams, Lukasz Cwiklik, H. Allen, Martina Roeselová, V. Vaida   +7 more
semanticscholar   +1 more source

Photophysics of phenylalanine analogues

Journal of Photochemistry and Photobiology A: Chemistry, 2001
The photophysical properties (fluorescence quantum yields and lifetimes) of linear analogues of phenylalanine (Phe) [β-homophenylalanine (β-Hph), β-phenylalanine (β-Phe), phenyglycine (Phg)] in water at pH=6 and 1 have been measured. The obtained results indicate that relative space location of the amino, carboxyl groups and phenyl chromophore ...
Joanna Malicka, Alicja Rzeska, Wiesław Wiczk, Leszek Lankiewicz, Aneta Szymańska, Krystyna Stachowiak   +5 more
openaire   +2 more sources

Studies of Ochratoxin A-Induced Inhibition of Phenylalanine Hydroxylase and Its Reversal by Phenylalanine

Toxicology and Applied Pharmacology, 2000
Ochratoxin A (OTA) is a nephrotoxic, hepatotoxic, and teratogenic mycotoxin produced by storage molds on a variety of foodstuffs. Its chemical structure is composed of an isocumarin part linked to l-phenylalanine. Inhibition of phenylalanine hydroxylase and other enzymes that use phenylalanine as substrate is based on this structural homology.
Tihana Žanić-Grubišić, Božica Radić, Ivana Čepelak, Renata Zrinski, Jozsef Petrik, Stjepan Pepeljnjak   +5 more
openaire   +4 more sources

Phenylalanine deficiency syndrome

The Journal of Pediatrics, 1966
Clinical observations are recorded on two infants in whom failure to gain, eczema and listlessness developed during severe dietary restriction of phenylalanine. Regular diet was resumed when they were found not to have phenylketonuria; in spite of improvement in their nutritional status, their developmental progress remained slow.
openaire   +3 more sources