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Phenylalanine ammonia lyase (PAL): From discovery to enzyme substitution therapy for phenylketonuria
Molecular Genetics and Metabolism, 2018Phenylketonuria (PKU) is a genetic inborn error in metabolism that impacts many people globally, with profound individual and societal consequences when left untreated. The journey of phenylalanine ammonia lyase (PAL) from plant enzyme to enzyme substitution therapy for PKU is a fascinating story that illustrates the importance of collaboration between
Harvey L, Levy +2 more
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Food Chemistry, 2013
In the present study, six cyanobacteria isolates were evaluated for the PAL enzyme activity, and their methanol extracts were assessed for the total phenolic amount and other antioxidant parameters. Synechocystis sp. BASO444 and Synechocystis sp. BASO673 isolates with high levels of total phenols (66.0±1.2μg/mg, 78.1±1.8μg/mg, respectively) also showed
ASLIM, BELMA +2 more
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In the present study, six cyanobacteria isolates were evaluated for the PAL enzyme activity, and their methanol extracts were assessed for the total phenolic amount and other antioxidant parameters. Synechocystis sp. BASO444 and Synechocystis sp. BASO673 isolates with high levels of total phenols (66.0±1.2μg/mg, 78.1±1.8μg/mg, respectively) also showed
ASLIM, BELMA +2 more
openaire +5 more sources
Journal of the Science of Food and Agriculture, 1998
Gibberellic acid (GA 3 ) treatments (30 and 60 μg litre -1 ) were applied to young plants (Fragaria ananassa cv Chandler). Fruits were harvested at various developmental stages (14, 21, 28 and 35 days from fruit set). Weight and size, phenolic compounds (total polyphenols and anthocyanins) and enzyme activities, phenylalanine ammonia-lyase (PAL) and ...
Teresa Montero +3 more
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Gibberellic acid (GA 3 ) treatments (30 and 60 μg litre -1 ) were applied to young plants (Fragaria ananassa cv Chandler). Fruits were harvested at various developmental stages (14, 21, 28 and 35 days from fruit set). Weight and size, phenolic compounds (total polyphenols and anthocyanins) and enzyme activities, phenylalanine ammonia-lyase (PAL) and ...
Teresa Montero +3 more
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Phytochemistry, 2004
In Arabidopsis thaliana, four genes have been annotated as provisionally encoding PAL. In this study, recombinant native AtPAL1, 2, and 4 were demonstrated to be catalytically competent for l-phenylalanine deamination, whereas AtPAL3, obtained as a N-terminal His-tagged protein, was of very low activity and only detectable at high substrate ...
Fiona C, Cochrane +2 more
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In Arabidopsis thaliana, four genes have been annotated as provisionally encoding PAL. In this study, recombinant native AtPAL1, 2, and 4 were demonstrated to be catalytically competent for l-phenylalanine deamination, whereas AtPAL3, obtained as a N-terminal His-tagged protein, was of very low activity and only detectable at high substrate ...
Fiona C, Cochrane +2 more
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Biochemical Genetics, 2023
The phenylalanine ammonia lyase (PAL) catalyses the first step of phenylpropanoid metabolic pathway which leads to the biosynthesis of a diverse group of secondary metabolites. Orchids serve as a rich source of metabolites and the availability of genome or transcriptome for selected orchid species provides an opportunity to analyse the PAL genes in ...
Arshpreet, Kaur +3 more
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The phenylalanine ammonia lyase (PAL) catalyses the first step of phenylpropanoid metabolic pathway which leads to the biosynthesis of a diverse group of secondary metabolites. Orchids serve as a rich source of metabolites and the availability of genome or transcriptome for selected orchid species provides an opportunity to analyse the PAL genes in ...
Arshpreet, Kaur +3 more
openaire +2 more sources
Induction of phenylalanine ammonia lyase (PAL) in gamma irradiated potatoes
Radiation Botany, 1975The exposure of potatoes to gamma rays (10 krad) caused on induction of phenylalanine ammonia lyase (PAL) in the tubers. The induced activity was localized essentially in cortex tissue, mainly concentrated around the bud region. Whereas in parenchymatous tissue no induction was observed.
M.B. Pendharkar, P.M. Nair
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Stimulation of L-phenylalanine ammonia-lyase (PAL) activity by D-phenylalanine in germinating seeds
Plant Science Letters, 1975Abstract D-Phenylalanine, contrary to its L-stereoisomer causes an increase in L-phenylalanine ammonia-lyase (PAL) activity during the culture of dormant and stratified apple embryos and during the germination of mustard, rape and oat seeds. None of the other six pairs of L- and D-aminoacids tested caused a comparable effect. It was demonstrated that
Krystyna Szkutnicka, Stanislaw Lewak
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Occurrence of Phenylalanine Ammonia-Lyase (PAL) in isolated tapetum cells ofTulipa anthers
Protoplasma, 19831. Cells and protoplasts were isolated from the tapetum in order to demonstrate the importance of this tissue in the phenylpropanoid metabolism of the anther loculus. It was our purpose to investigate the localization of the key phenylpropanoid enzyme, phenylalanine ammonia-lyase, within the tapetum and the other anther tissues. 2.
M. Rittscher, R. Wiermann
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Planta, 2013
Phenylalanine ammonia-lyase (PAL) catalyzes the initial step of phenylpropanoid biosynthesis in plants. Five PAL genes (PtrPAL1 to 5) have been identified in Populus trichocarpa. These genes are classified into two subgroups according to their transcript sequence similarity and tissue specificity.
Rui, Shi +11 more
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Phenylalanine ammonia-lyase (PAL) catalyzes the initial step of phenylpropanoid biosynthesis in plants. Five PAL genes (PtrPAL1 to 5) have been identified in Populus trichocarpa. These genes are classified into two subgroups according to their transcript sequence similarity and tissue specificity.
Rui, Shi +11 more
openaire +2 more sources