Results 141 to 150 of about 152,932 (290)

Thermodynamics of iron, tetrahydrobiopterin, and phenylalanine binding to phenylalanine hydroxylase from Chromobacterium violaceum. [PDF]

Arch Biochem Biophys, 2022
Li M, Subedi BP, Fitzpatrick PF, Emerson JP.   +3 more
europepmc   +1 more source

Unveiling Parkinson's Disease-like Changes Triggered by Spaceflight [PDF]

arXiv
A meta-analysis of spaceflight data from both mouse and human flights reveals a striking overlap with Parkinson's disease (PD). Parallels include: changes in gait, loss of dopamine, sustained changes in the basal ganglia, loss of tyrosine hydroxylase in the substantia nigra, and systemic mitochondrial dysfunction.
arxiv  

The chromosome‐scale assembly of the Salvia plebeia genome provides insight into the biosynthesis and regulation of rosmarinic acid

Plant Biotechnology Journal, Volume 23, Issue 5, Page 1507-1520, May 2025.
Summary Salvia plebeia is an important traditional Chinese medicinal herb, with flavonoids and phenolic acids as its primary bioactive components. However, the absence of a reference genome hinders our understanding of genetic basis underlying the synthesis of these components.
Yiqun Dai, Mengqian He, Hui Liu, Huihui Zeng, Kaixuan Wang, Rui Wang, Xiaojing Ma, Yan Zhu, Guoyong Xie, Yucheng Zhao, Minjian Qin   +10 more
wiley   +1 more source

Alchemical Design of Pharmacological Chaperones with Higher Affinity for Phenylalanine Hydroxylase. [PDF]

Int J Mol Sci, 2022
Conde-Giménez M, Galano-Frutos JJ, Galiana-Cameo M, Mahía A, Victor BL, Salillas S, Velázquez-Campoy A, Brito RMM, Gálvez JA, Díaz-de-Villegas MD, Sancho J.   +10 more
europepmc   +1 more source

Two tandem R2R3 MYB transcription factor genes cooperatively regulate anthocyanin accumulation in potato tuber flesh

Plant Biotechnology Journal, Volume 23, Issue 5, Page 1521-1534, May 2025.
Summary Anthocyanin biosynthesis and accumulation determines the colour of tuber flesh in potato (Solanum tuberosum) and influences nutritional quality. However, the regulatory mechanism behind anthocyanin biosynthesis in potato tuber flesh remains unclear.
Hui Du, Zefeng Zhai, Jin Pu, Jun Liang, Rongyan Wang, Zhong Zhang, Pei Wang, Yanhui Zhu, Lian Huang, Dawei Li, Kaiyuan Chen, Guangtao Zhu, Chunzhi Zhang   +12 more
wiley   +1 more source

A method for phenylalanine self-monitoring using phenylalanine ammonia-lyase and a pre-existing portable ammonia detection system

Molecular Genetics and Metabolism Reports, 2023
Phenylketonuria is an inborn error of phenylalanine metabolism caused by a phenylalanine hydroxylase deficiency. To prevent the occurrence of neurological symptoms and maternal complications resulting from phenylketonuria, patients must adhere to a ...
Yoichi Wada, Eriko Totsune, Yasuko Mikami-Saito, Atsuo Kikuchi, Toshio Miyata, Shigeo Kure   +5 more
doaj  

Generation of suspension cell cultures with high syringin content and anti‐inflammatory activity through overexpressing glycotransferase SiUGT72BZ2 in Saussurea involucrata

Plant Biotechnology Journal, Volume 23, Issue 5, Page 1713-1724, May 2025.
Summary The snow lotus species Saussurea involucrata (Kar. & Kir.) Sch.Bip., an endangered traditional Chinese herb, belongs to a genus of the Asteraceae family. Syringin present in S. involucrata stands as one of the predominant bioactive compounds. However, the biosynthetic pathway of syringin remains largely elusive. Here, S.
Yue Xu, Yingping Cao, Fangfang Tie, Xiuya Kong, Yuchen Liu, Yaru Zhang, Wenna Guan, Na Hu, Honglun Wang, Xiaochun Qin, Zhenying Wu, Chunxiang Fu   +11 more
wiley   +1 more source

Impact of Fluorinated Ionic Liquids on Human Phenylalanine Hydroxylase-A Potential Drug Delivery System. [PDF]

Nanomaterials (Basel), 2022
Alves MMS, Leandro P, Mertens HDT, Pereiro AB, Archer M.   +4 more
europepmc   +1 more source

Host Metabolites in Asparagus–Fusarium Interaction: Mechanisms and Regulation

Plant Pathology, Volume 74, Issue 4, Page 923-942, May 2025.
Specific host metabolites regulate Fusarium pathogenicity by modulating fungal gene expression, growth, mycotoxin biosynthesis, enhancing asparagus defence responses and ultimately affecting disease severity. ABSTRACT Asparagus (Asparagus officinalis) is an important perennial vegetable crop cultivated worldwide.
Elsie Ayamoh Enow, Monika Urbaniak, Łukasz Stępień   +2 more
wiley   +1 more source

Birth prevalence of phenylalanine hydroxylase deficiency: a systematic literature review and meta-analysis. [PDF]

Orphanet J Rare Dis, 2021
Foreman PK, Margulis AV, Alexander K, Shediac R, Calingaert B, Harding A, Pladevall-Vila M, Landis S.   +7 more
europepmc   +1 more source