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Ocular absorption and disposition of phenylephrine and phenylephrine oxazolidine
Biopharmaceutics & Drug Disposition, 1988AbstractThe ocular bioavailability of phenylephrine oxazolidine (PO), a prodrug intended for rapid corneal penetration, was micronized and suspended in sesame oil (1 and 10 per cent) and compared in bioavailability to phenylephrine HCl (PE) dissolved (10 per cent) in a buffered (pH 5.75), viscous (30 centipoise) vehicle. Cornea and aqueous humor of New
R D, Schoenwald, D S, Chien
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Ephedrine is Not Phenylephrine
New England Journal of Medicine, 1998To the Editor: In his review of Dermatology in Emergency Care (Feb. 12 issue),1 Dr. Greaves incorrectly uses the generic name ephedrine for a 2 percent phenylephrine spray used to treat a localized mucosal reaction. Phenylephrine hydrochloride is an α-adrenergic agonist that is useful for topical as well as intravenous vasoconstriction.
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