Results 61 to 70 of about 66,688 (258)
Exercise training and losartan improve endothelial function in heart failure rats by different mechanisms [PDF]
, 2013 Objectives. To investigate the mechanisms of losartan- and exercise training-induced improvements on endothelial dysfunction in heart failure. Design. Sprague-Dawley rats subjected to left coronary artery ligation inducing myocardial infarction and heart
Crozier I +5 more
core +1 more source
VIEW, EarlyView.Inhibiting the SUMOylation modification of TRPM4 can prevent the vascular endothelial damage caused by ATO. Inhibition of TRPM4 SUMOylation, either pharmacologically by GA or genetically by the K618R mutation, protects against ATO‐induced vascular endothelial damage.
Ting‐Ting Tong +18 more
wiley +1 more source
Reversal of aging-induced increases in aortic stiffness by targeting cytoskeletal protein-protein interfaces [PDF]
, 2018 BACKGROUND: The proximal aorta normally functions as a critical shock absorber that protects small downstream vessels from damage by pressure and flow pulsatility generated by the heart during systole.
Chiu, Joanna +10 more
core +1 more source
Acta Ophthalmologica, EarlyView.Abstract Purpose To study ocular fundus morphology and its relation to growth in adolescents born moderate‐to‐late preterm (MLP) and full term. Methods This prospective and population‐based cohort study included 50 MLP adolescents (26 girls, mean age 16.5 years) and 50 full‐term controls (30 girls, mean age 16.7 years).
Alexandra Lind +6 more
wiley +1 more source
TRAF Family Member 4 Promotes Cardiac Hypertrophy Through the Activation of the AKT Pathway
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Pathological cardiac hypertrophy is a major cause of heart failure morbidity. The complex mechanism of intermolecular interactions underlying the pathogenesis of cardiac hypertrophy has led to a lack of development and application of ...
Jian Li +7 more
doaj +1 more source
The Role of Sex Hormones in Inducing Maternal Uterine Remodeling and Vasodilation During Pregnancy [PDF]
, 2018 Uterine vascular adaptations such as vessel growth and vasodilation are needed to facilitate the more than 10-fold increase of uteroplacental blood flow (UPBF) during pregnancy.
Glessner-Fischer, Annie D.
core +1 more source
Inhibition of histone deacetylase as a treatment for cardiac hypertrophy [PDF]
, 2005 The present invention provides for methods of treating and preventing cardiac hypertrophy. Class II HDACs, which are known to participate in regulation of chromatin structure and gene expression, have been shown to have beneficial effects on cardiac ...
Bristow, Michael R. +3 more
core +1 more source
Axial length, myopia progression, and myopic maculopathy in Stickler syndrome
Acta Ophthalmologica, EarlyView.Abstract Purpose We lack knowledge on the potentially progressive nature of and the prevalence of complications to myopia as a characteristic trait of Stickler syndrome. Methods This cross‐sectional study combines ophthalmic examination and medical record data on Danish patients with genetically confirmed Stickler syndrome type 1 (COL2A1) and type 2 ...
Kirstine B. Boysen +4 more
wiley +1 more source
Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia [PDF]
, 2015 Deletion of exon 9 from Cullin‐3 (CUL3, residues 403–459: CUL3Δ403–459) causes pseudohypoaldosteronism type IIE (PHA2E), a severe form of familial hyperkalaemia and hypertension (FHHt).
Al Maskari, Raya S. +14 more
core +4 more sources
Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source