Results 11 to 20 of about 7,455 (171)

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

The Role of Proteins in the Sensory Perception/Organoleptic Properties of Food

Food Chemistry International, EarlyView.
Protein structure controls sensory attributes such as flavor, texture, and aroma. This can occur during amino acid breakdown, Maillard reactions and lipid–protein interactions which generate flavor profiles. Bioactive peptides also provide taste and health benefits.
Tharuka Wijesekara, Idaresit Ekaette
wiley   +1 more source

Federation of Gynecology and Obstetrics good practice recommendations on preconception care: A strategy to prevent preterm birth

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Preterm birth (PTB) remains one of the leading causes of neonatal mortality and long‐term morbidity worldwide, with minimal progress being made in reducing its incidence, particularly in low‐resource settings. Preconception care is recognized as an effective strategy for PTB prevention; however, the fact that more than half of pregnancies ...
Leticia Irma Ojeda, Catalina M. Valencia G, Natalia Cardozo Buitrago, Dilly Anumba, Wondimu Gudu, Ana Bianchi, Bo Jacobson, on behalf of the FIGO Committee for Preterm Birth, Catalina M. Valencia González, Dilly Anumba, Wondimu Gudu, Bo Jacobsson, Nancy Sierra Lozada, Leticia Ojeda, Madhuri Patel, Andrew Shennan, Rodrigo Rigoni, Priya Soma‐Pillay, Sherri Ann Suplido, Ana Daneva, Sikolia Wanyonyi, Haim Abenhaim   +21 more
wiley   +1 more source

New insights into applications of base editor in hereditary disorders

Interdisciplinary Medicine, EarlyView.
Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai, Linhui Zhang, Liqing Li, Yue Liu, Canbin Lv, Yan Shi, Jianyuan Zhao, Dingwei Ye, Yuanyuan Qu   +8 more
wiley   +1 more source

Hydrophobic Drug Delivery into T Cells Using Carboxy‐Terminal Phenylalanine‐Modified Dendrigraft Polylysines

Macromolecular Bioscience, EarlyView.
In this study, dendrigraft polylysines (DGLs) modified with 1,2‐cyclohexanedicarboxylic acid (CHex) and phenylalanine (Phe) were synthesized using different generations of DGL by reacting with Phe at different ratios for drug delivery to T cells. DGL(G3)‐CHex‐Phe93 was associated with T cells efficiently, retained a model hydrophobic drug, paclitaxel ...
Chie Kojima, Akinobu Sakai, Tetsuya Kadonosono   +2 more
wiley   +1 more source

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods, EarlyView.
The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
wiley   +1 more source

Open Framework Structure of the New Pure‐Germania Zeolite ITQ‐35 Solved by 3D Electron Diffraction

Small Methods, EarlyView.
The synthesis and characterization of the pure germania zeolite ITQ‐35 are described. Its complete structure determination, including the organic structure directing agent, is performed using 3D electron diffraction, theoretical calculations, and powder X‐ray diffraction data.
Juan Ignacio Tirado, Jose Valero, Partha Pratim Das, Lukáš Palatinus, Stavros Nicolopoulos, Jose Luis Jordá, German Sastre, Angel Cantín, Susana Valencia, Fernando Rey   +9 more
wiley   +1 more source

Phenylketonuria: a review [PDF]

Postgraduate Medical Journal, 1970
SummaryThe development of a practical screening procedure for phenylketonuria and the improvement in methods of chemical analysis have led to a realization that Folling’s (1934) disease of phenylketonuria is not a single entity.In this commentary, the current view on some aspects of phenylketonuria will be reviewed and the problems illustrated by ...
openaire   +3 more sources

Silencing of juvenile hormone‐related genes through RNA interference leads to molt failure and high mortality in the spongy moth

Insect Science, EarlyView.
The feasibility of using RNA interference to control the globally important quarantine pest, the spongy moth. Targeting genes related to JHs play an important role in the growth and development of insects. First, the open reading frames (ORFs) of Ldjhamt and Ldjheh were identified and characterized, and the target genes were cloned and double‐stranded ...
Wenzhuai Ji, Qing Xie, Xiaoxiao Chang, Juan Shi   +3 more
wiley   +1 more source

CRISPR Technology in Disease Management: An Updated Review of Clinical Translation and Therapeutic Potential

Cell Proliferation, EarlyView.
CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far, Marziyeh Akbari, Mohammad Amin Habibi, Morteza Katavand, Sherko Nasseri   +4 more
wiley   +1 more source