Results 61 to 70 of about 18,327 (286)

Urinary neopterin concentrations vs total neopterins for clinical utility [PDF]

, 1989
Fuchs D, Milstien S, Krämer A, et al. Urinary neopterin concentrations vs total neopterins for clinical utility. Clinical Chemistry. 1989;35(12):2305-2307.Neopterin measurements are especially useful as an early marker in (e.g.) allograft rejections and ...
Fuchs, Dietmar, Goedert, James J., Kaufman, Seymour, Krämer, Alexander , Milstien, Sheldon, Reibnegger, Gilbert, Wachter, Helmut, Werner, Ernst R.   +7 more
core   +1 more source

Identification of a Novel Mutation in the PAH Gene in an Iranian Phenylketonuria Family: A Case Report

Iranian Journal of Public Health, 2017
Phenylketonuria (PKU) is an inborn error of amino acid metabolism with an autosomal recessive inheritance caused in most cases by mutations in the phenylalanine hydroxylase (PAH) gene. PKU has wide allelic heterogeneity.
Masoumeh RAZIPOUR, Daniz KOOSHAVAR, Elaheh ALAVINEJAD, Seyede Zahra SAJEDI, Neda MOHAJER, Aria SETOODEH, Saeed TALEBI, Mohammad KERAMATIPOUR   +7 more
doaj  

Delivery strategies of messenger RNA therapeutics for brain disorders

Bulletin of the Korean Chemical Society, EarlyView.
Thus, mRNA therapeutics offer a powerful new avenue for the treatment of brain diseases. This review examines strategies to bypass biological barriers, particularly the blood–brain barrier, and explores emerging delivery systems, such as direct intracerebral injection, intracerebroventricular injection, systemic delivery (including intravenous ...
Kounghwa Youn, Sunmin Oh, Hyunchae Gil, Yongseok Choi, Gyochang Keum, Eun‐Kyoung Bang   +5 more
wiley   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Diagnostic odyssey for rare diseases: exploration of potential indicators [PDF]

, 2015
To explore whether an accurate, robust and cost-effective method can be developed for the routine measurement of the rare diseases diagnostic odysseys to enable the impact of interventions and policies, such as the 2013 UK Strategy for Rare Diseases, to ...
Black, N, Manacorda, Tommaso, Martineau, F   +2 more
core  

Crosstalk Between Metastatic Cancer Cells and the Bone Microenvironment

Cancer Nexus, EarlyView.
ABSTRACT Bone metastasis is highly prevalent in breast, prostate, and lung cancers and is strongly correlated with poor clinical outcomes and the occurrence of skeletal‐related events (SREs). Bidirectional communication between tumor cells and bone‐resident cells provides selective advantages that promote tumor growth, resulting in either bone ...
Kunhao Zhou, Hongquan Zhang, Yu Yu
wiley   +1 more source

Breastfeeding follow-up in the treatment of children with phenylketonuria [PDF]

A fenilcetonúria (PKU) ocorre na incapacidade para transformar fenilalanina em tirosina, trazendo efeitos tóxicos para o sistema nervoso central. Tradicionalmente, no tratamento da PKU, o aleitamento materno é substituído por fórmula láctea.
Anastácio-Pessan, Fernanda da Luz, Caldeira, Ana Cláudia Gandara Casarin, Gejão, Mariana Germano, Lamônica, Dionísia Aparecida Cusin, Pedro, Karla Panice, Rolim-Liporacci, Maura Contieri, Stump, Marisdalva Viegas   +6 more
core   +1 more source

Transendocardial injection of expanded autologous CD34+ cells after myocardial infarction: Design of the EXCELLENT trial

ESC Heart Failure, Volume 12, Issue 2, Page 1455-1463, April 2025.
Abstract Aims The extent of irreversible cardiomyocyte necrosis after acute myocardial infarction (AMI) is a major determinant of residual left ventricular (LV) function and clinical outcome. Cell therapy based on CD34+ cells has emerged as an option to help repair the myocardium and to improve outcomes.
Jerome Roncalli, François Roubille, Nicolas Meyer, Giulio Pompilio, Lionel Leroux, Philippe Henon, Guillaume Trebuchet, Anthony Criquet, Matthieu de Kalbermatten, Eric Saloux, Alain Manrique, Pierre‐Yves Marie, Deepak L. Bhatt, Scott D. Solomon, Gilles Montalescot, David E. Newby, Faiez Zannad, on behalf of the EXCELLENT Trial Investigators   +17 more
wiley   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Molecular imprinting for neurology: Materials, applications, and limitations

Ibrain, EarlyView.
Molecularly imprinted materials: diagnostic, therapeutic and research applications in neurology. Molecularly imprinted materials offer high specificity and affinity for target molecules in neurological applications. This review highlights their synthesis, characterisation, and use in diagnostics, research and therapeutics.
Xiaohan Ma, Yingqi Ma, Claudia Marino, Alessandro Poma   +3 more
wiley   +1 more source