Microbial Hydroxylation of 2-Phenylpropionic Acid [PDF]
The hydroxylation of 2-phenylpropionic acid (PPH) to 2-(p-hydroxyphenyl)propionic acid (HPPH) was investigated using various microorganisms. The highest hydroxylating activity was found in Streptomyces rimosus ATCC 10907. The reaction product was isolated and identified as 2-(p-Miydroxyphenyl)propionic acid, which had no specific rotation, indicating ...
KUGE, Yukihiro +2 more
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A Chirality Chain in Phenylglycine, Phenylpropionic Acid, and Ibuprofen [PDF]
Our strategy to analyze the structures of natural amino acids with respect to the interaction of three different elements of chirality within the molecules was applied to the non-natural amino acid (S)-α-phenylglycine, its analogue (S)-α-phenylpropionic acid, and the drug (S)-ibuprofen.
Henri Brunner +2 more
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The metabolism of β-phenylpropionic acid by an Achromobacter [PDF]
1. When a species of Achromobacter grew with beta-phenylpropionate as carbon source, 2-hydroxy-beta-phenylpropionate and 2,3-dihydroxy-beta-phenylpropionate appeared in the growth medium. The concentrations of these compounds were maximal during exponential growth. 2.
S, Dagley, P J, Chapman, D T, Gibson
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Ethyl 3-(diphenylphosphinoyl)-3-phenylpropionate
The title compound, Ph2P(O)CH(Ph)CH2COOEt or C23H23O3P, (I), assembles into columns extending down the a axis, via C—H⋯O hydrogen bonds. Compound (I) was isolated as a by-product in studies related to the development of a novel cyclization reaction [Evans et al. (2002). Tetrahedron Lett.
Light, M. E. +3 more
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A small-molecule degron with a phenylpropionic acid scaffold
Targeted protein degradation (TPD), employing proteolysis-targeting chimeras (PROTACs) composed of ligands for both a target protein and ubiquitin ligase (E3) to redirect the ubiquitin-proteasome system (UPS) to the target protein, has emerged as a promising strategy in drug discovery.
Shusuke Tomoshige +9 more
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Syntheses of deuterated phenylpropionic acid derivatives.
2-(4-(2-Thienylhydroxymethyl)phenyl) propionic acid (I), 2-(4-carboxyphenyl) propionic acid (II), 2-(4-(5-hydroxy-2-thienylcarbonyl)phenyl)propionic acid (III) were labeled with multiple-deuterium for the purpose of using as internal standards in studies on the metabolism of 2-(4-(2-thienylcarbonyl)phenyl)propionic acid (suprofen, IV), anti ...
MORI, Yukio +5 more
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Ethyl 2-methoxycarbonylamino-3-phenylpropionate
The title compound, C13H17NO4, has been obtained as an unexpected product when attempting to prepare diethyl (S)-2-(2-methoxycarbonylamino-3-phenylpropionyl)malonate. The crystal structure involves intermolecular N—H⋯O hydrogen bonds.
Tan, B, Fang, H, Wei, ZB, Jin, LR
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Moderator Effects on Recoil Tritium Reactions with Lithium β-Phenylpropionate
The recoil tritium reactions were studied with lithium beta-phenylpropionate having both the aromatic and aliphatic C-H bonds in the molecule, mainly in terms of the moderator effect on the intramolecular tritium distribution. Recoil tritium atoms were produced by the 6Li(n,alpha)3H reaction. Water molecules were used as the moderator.
OOHASHI, Kunio, MORIKAWA, Naotake
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Hydrocinnamic Acid From Candida albicans: Isolation, Characterization, and Antibacterial Activity Against Multidrug-Resistant Bacteria. [PDF]
Kaviraj M, Jayappriyan KR, Raja R.
europepmc +1 more source
Effectiveness of Saroglitazar in MASLD Patients: A Prospective, Real-World Assessment of Liver and Metabolic Health. [PDF]
Gupta M +4 more
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