Results 11 to 20 of about 1,536 (125)

Assessment of Annona muricata Phytochemicals as 17β‐HSD1 Inhibitors through Molecular Docking, Dynamics Simulation, DFT, and ADMET Analyses

open access: yesJournal of Cellular and Molecular Medicine, Volume 29, Issue 21, November 2025.
Breast cancer remains a leading cause of female mortality, largely sustained by local oestrogen production. The enzyme 17β‐hydroxysteroid dehydrogenase type 1 (17β‐HSD1) is an enzyme involved in the oestrogen biosynthesis pathway, particularly in the ...
E. R. Sindi   +9 more
semanticscholar   +2 more sources

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

open access: yesAngewandte Chemie, Volume 138, Issue 23, 1 June 2026.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach   +4 more
wiley   +2 more sources

Detection of Testosterone Esters in Urine: Evidence of Trace‐Level Detectability in Doping Control Samples

open access: yesDrug Testing and Analysis, Volume 18, Issue 9, Page 1157-1162, September 2026.
An ultrasensitive LC‐MS/MS method for detecting testosterone esters (T‐esters) in urine at sub–pg/mL levels is presented. This approach, employing Girard P derivatization, provides the first evidence of T‐esters' trace‐level detectability in human urine.
Daniel Pecher   +3 more
wiley   +1 more source

The Microbiome as a Mirror: Distinguishing Healthy Individuals From Chronic Constipated Patients and Identifying Those With Hidden Psychiatric Burden

open access: yesMicrobiota Medicine Research, Volume 1, Issue 3, Page 91-106, September 2026.
Gut microbiota signatures distinguish chronic constipated patients from healthy individuals, supporting noninvasive diagnostic potential. Despite challenges in identifying psychiatric‐related comorbidities, microbial alterations, particularly in neurotransmitter and inflammatory pathways, lay the groundwork for future companion diagnostics and ...
Hongyan Qi   +7 more
wiley   +1 more source

The Antimycobacterial Activity, Toxicity and Chemical Composition of South African Propolis

open access: yesChemistry &Biodiversity, Volume 23, Issue 8, August 2026.
This study presents one of the largest geographically diverse propolis collections reported globally, comprising 109 samples sourced from eight provinces across South Africa. The novelty of this work lies in the fact that it presents the first investigation of South African propolis against M. tuberculosis.
Nyiko F. Mzimba   +6 more
wiley   +1 more source

Main Group Metals in Redox Catalysis

open access: yesEuropean Journal of Inorganic Chemistry, Volume 29, Issue 22, 1 August 2026.
Main group metal redox catalysis is emerging as a credible alternative to transition metal chemistry. Elements from groups 13 to 15 now enable diverse catalytic manifolds, driven by ligand design and control of electronic structure. This review highlights recent advances, key design principles, and remaining challenges, positioning main group metals as
Olympia Mouriki   +2 more
wiley   +1 more source

Electronic Smoking Devices Among University Students: Usage Patterns and Chemical Composition of Inhaled Substances

open access: yesAnalytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT This study investigated the prevalence of electronic smoking device (ESD) use and its associated behavioural and chemical risks among university students in Bahia, Brazil. A cross‐sectional survey was conducted with 355 students from public and private institutions through an online questionnaire between April and May 2023. Among participants,
Eduard F. Valenzuela   +7 more
wiley   +1 more source

Rapid Analysis of Sports Prohibited Substances in Black Market Pharmaceutical Products Using Atmospheric Solids Analysis Probe‐Mass Spectrometry

open access: yesAnalytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT Misuse of performance‐enhancing substances in sport remains a persistent threat to the values of fair competition, with estimated doping prevalence far exceeding adverse analytical findings in routine testing. This highlights the need for improved surveillance tools capable of rapid and simple, on‐site screening methods.
Alisha Henderson   +7 more
wiley   +1 more source

Annual Banned‐Substance Review 18th Edition—Analytical Approaches in Human Sports Drug Testing 2024/2025

open access: yesDrug Testing and Analysis, Volume 18, Issue 4, Page 458-482, April 2026.
New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

Rare Neurosarcoidosis Involvements

open access: yesRespirology Case Reports, Volume 14, Issue 3, March 2026.
Neurosarcoidosis is a rare manifestation of systemic sarcoidosis. Establishing a diagnosis can be challenging for clinicians, particularly in cases of isolated neurosarcoidosis. Here, we present nine patients with rare manifestations of neurosarcoidosis. ABSTRACT Neurosarcoidosis is a rare manifestation of systemic sarcoidosis. Establishing a diagnosis
Gülce Cansu Serin   +3 more
wiley   +1 more source

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