Results 291 to 300 of about 93,963 (358)
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HLA Alleles and CYP2C9*3 as Predictors of Phenytoin Hypersensitivity in East Asians
Clinical pharmacology and therapy, 2018To develop a pre‐emptive genetic test that comprises multiple predisposing alleles for the prevention of phenytoin‐related severe cutaneous adverse reactions (SCARs), three sets of patients with phenytoin‐SCAR and drug‐tolerant controls from Taiwan ...
S. Su +21 more
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The bioavailability of phenytoin
Journal of Neurology, 1977The bioavailability of three commercial products of phenytoin (Epanutin, sodium salt; Phenhydan, calcium salt; Zentropil, free acid) was studied relative to a standard solution of sodium phenytoin. Each preparation was given for 14 days in a daily dose of 300 mg according to a cross over design.
R, Gugler +3 more
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Southern Medical Journal, 1991
We studied the clinical features of 85 cases of phenytoin toxicity in 76 patients treated at a general hospital. Serum levels of phenytoin on admission ranged from 30.3 to 95.0 micrograms/mL (median, 46.5). Iatrogenic causes of intoxication were common and included increased daily dosage and intravenous loading in the emergency room for single seizures
J M, Murphy, R, Motiwala, O, Devinsky
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We studied the clinical features of 85 cases of phenytoin toxicity in 76 patients treated at a general hospital. Serum levels of phenytoin on admission ranged from 30.3 to 95.0 micrograms/mL (median, 46.5). Iatrogenic causes of intoxication were common and included increased daily dosage and intravenous loading in the emergency room for single seizures
J M, Murphy, R, Motiwala, O, Devinsky
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Annals of Internal Medicine, 1989
Excerpt To the Editor:We read with interest the recent letter (1) in which antiseizure prophylaxis was recommended for patients receiving high-dose busulphan, 16 mg/kg body weight over 4 consecutiv...
A P, Grigg, J D, Shepherd, G L, Phillips
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Excerpt To the Editor:We read with interest the recent letter (1) in which antiseizure prophylaxis was recommended for patients receiving high-dose busulphan, 16 mg/kg body weight over 4 consecutiv...
A P, Grigg, J D, Shepherd, G L, Phillips
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Medical Journal of Australia, 1979
Large doses (up to 1200 mg) of phenytoin were required to achieve therapeutic plasma concentrations and to control post-traumatic seizures in a 62-year-old woman. The elimination half-life of phenytoin was calculated to be 3.5 hours. Frequent monitoring of the plasma concentration was essential to optimize the therapeutic control and to avoid systemic ...
C G, Meredith +3 more
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Large doses (up to 1200 mg) of phenytoin were required to achieve therapeutic plasma concentrations and to control post-traumatic seizures in a 62-year-old woman. The elimination half-life of phenytoin was calculated to be 3.5 hours. Frequent monitoring of the plasma concentration was essential to optimize the therapeutic control and to avoid systemic ...
C G, Meredith +3 more
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Clinical Pharmacology & Therapeutics, 1978
I wish to point out a significant error in the article by Peter W. Mullen, “Optimal phenytoin therapy: A new technique for individualizing dosage,” which appeared on page 228 of the February, 1978, issue of the Journal. In Table I, the serum phenytoin concentrations he predicted by using the method described by Ludden and colleagues (Clin.
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I wish to point out a significant error in the article by Peter W. Mullen, “Optimal phenytoin therapy: A new technique for individualizing dosage,” which appeared on page 228 of the February, 1978, issue of the Journal. In Table I, the serum phenytoin concentrations he predicted by using the method described by Ludden and colleagues (Clin.
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Annals of Internal Medicine, 1985
Excerpt To the editor: The recent report of Kushnir and associates (1), which describes the case of a patient who developed hypothyroidism during phenytoin intoxication, is of interest and should a...
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Excerpt To the editor: The recent report of Kushnir and associates (1), which describes the case of a patient who developed hypothyroidism during phenytoin intoxication, is of interest and should a...
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Neurocritical Care, 2005
Phenytoin toxicity may result from intentional overdose, dosage adjustments, drug interactions, or alterations in physiology. Intoxication manifests predominantly as nausea, central nervous system dysfunction (particularly confusion, nystagmus, and ataxia), with depressed conscious state, coma, and seizures occurring in more severe cases.
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Phenytoin toxicity may result from intentional overdose, dosage adjustments, drug interactions, or alterations in physiology. Intoxication manifests predominantly as nausea, central nervous system dysfunction (particularly confusion, nystagmus, and ataxia), with depressed conscious state, coma, and seizures occurring in more severe cases.
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Therapeutic Drug Monitoring, 1986
Numerous letters and reports located in the Parke, Davis and Smithsonian files add to the story of Merritt's and Putnam's discovery of the anticonvulsant (AC) properties of phenytoin. The major events preceding this work were the fortuitous discovery of phenobarbital as an AC agent, structure/hypnotic activity studies with barbiturates and hydantoins ...
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Numerous letters and reports located in the Parke, Davis and Smithsonian files add to the story of Merritt's and Putnam's discovery of the anticonvulsant (AC) properties of phenytoin. The major events preceding this work were the fortuitous discovery of phenobarbital as an AC agent, structure/hypnotic activity studies with barbiturates and hydantoins ...
openaire +2 more sources