Results 101 to 110 of about 178 (146)
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Phenytoin Toxicity and Hepatic Encephalopathy
Journal of Clinical Gastroenterology, 1987Two cases of phenytoin toxicity in patients with chronic liver disease who were taking 300 mg phenytoin daily are described. Each patient developed encephalopathy, characterized by confusion, disturbed conscious state, asterixis, and nystagmus, which was resistant to treatment with protein restriction, lactulose, and neomycin, but responsive to ...
N L, Sandford +3 more
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Phenytoin toxicity due to interaction‐ with clobazam
Neurology, 1991The benzodiazepine antiepileptic drug clobazam can be added to existing AED treatment, usually without clinical toxicity. We report 3 patients in whom the addition of clobazam led within several weeks to clinically obvious phenytoin (PHT) intoxication in patients who had been taking maximum tolerable PHT doses.
B, Zifkin, A, Sherwin, F, Andermann
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Ticlopidine-Induced Phenytoin Toxicity
Annals of Pharmacotherapy, 1998OBJECTIVE: To report a probable case of ticlopidine-induced phenytoin toxicity. CASE SUMMARY: A 72-year-old man suddenly developed combative behavior, refused to leave his room, stopped eating, and began falling to the floor 6 weeks ...
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Phenytoin-Induced Toxic Epidermal Necrolysis
Annals of Internal Medicine, 1979Excerpt Toxic epidermal necrolysis is one of the most severe adverse reactions to a drug. A mortality rate of approximately 25% has been reported (1, 2).
L E, Gately, M A, Lam
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Athetosis and Phenytoin Toxicity
Archives of Pediatrics & Adolescent Medicine, 1977Sir.—We were interested in the case report by Zinsmeister and Marks (Am J Dis Child130:75, 1976) of a child in whom acute athetosis in association with phenytoin toxicity developed. We are prompted to pass comment on these authors' observations, as we have recently encountered a similar clinical problem.
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Fluconazole-Induced Symptomatic Phenytoin Toxicity
Annals of Pharmacotherapy, 1994OBJECTIVE: To report two cases of fluconazole-induced symptomatic phenytoin toxicity and review literature related to this interaction. DATA SOURCES: Case reports and review articles identified by a computerized (MEDLINE) and manual ...
R M, Cadle +3 more
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Hypothyroxinemia and Phenytoin Toxicity: A Vicious Circle
Drug Metabolism and Drug Interactions, 1996Phenytoin is a widely used anticonvulsant which has a relatively narrow therapeutic range of serum concentrations, 40-80 mmol/l (10-20 mg/l). Phenytoin is known to show concentration-dependent kinetics within this therapeutic range. Because of this, small changes in dose and minor alterations in hepatic metabolism of phenytoin may cause a ...
T C, Sarich, J M, Wright
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Hypothermia and Phenytoin Toxicity: A Case Report
Clinical Neuropharmacology, 2001Phenytoin toxicity continues to be a common medical problem. It can present with subtle and atypical symptoms. Herein the authors report what is, to their knowledge, the first case in the literature of phenytoin toxicity that manifested solely in the form of hypothermia.
E, Alhaj, N, Alhaj
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