Results 101 to 110 of about 10,598 (216)
RLIP76, a non-ABC transporter, and drug resistance in epilepsy
BMC Neuroscience, 2005 Background Permeability of the blood-brain barrier is one of the factors determining the bioavailability of therapeutic drugs and resistance to chemically different antiepileptic drugs is a consequence of decreased intracerebral accumulation.
Awasthi Yogesh C +7 more
doaj +1 more source
Health Science Reports, Volume 9, Issue 8, August 2026.ABSTRACT Background and Aims The HLA‐B*15:02 allele is related to a high risk of severe cutaneous adverse drug reactions (SCARs) in patients taking certain antiepileptic drugs. However, its prevalence in the Asian population and the number of drugs linked to SCARs due to the carriage of this variant are relatively underexplored.
Mohitosh Biswas +3 more
wiley +1 more source
Veterinary Record Case Reports, Volume 14, Issue 3, August 2026.Abstract A 1‐year‐old, female, spayed, mixed‐breed dog was examined by a referring veterinarian for a 1‐week history of sneezing, bilateral mucoid nasal discharge, mild bilateral ocular discharge and stertor. During rhinoscopy, a plant awn foreign body was removed, but upper respiratory signs persisted. Computed tomography of the head revealed findings
Glynn Woods +4 more
wiley +1 more source
“Trapped in silence”: Chronic Phenytoin Toxicity in a Nonverbal Elderly with Cerebral Palsy [PDF]
Background: Phenytoin is the one of the oldest and widely prescribed anticonvulsant drugs with a narrow therapeutic index, exhibiting saturable metabolism at higher concentrations, hence small dose changes can disproportionately raise serum levels and ...
Durazo, Yareli +4 more
core +1 more source
Elevation of plasma phenytoin by viloxazine in epileptic patients: a clinically significant drug interaction. [PDF]
, 1992 The effect of viloxazine (150-300 mg daily for 21 days) on plasma phenytoin levels at steady state was examined in 10 epileptic patients stabilised on a fixed phenytoin dosage.
R. Trio +7 more
core +1 more source
Frontiers in PharmacologyDespite the availability of effective vaccines and treatments for SARS-CoV-2, managing COVID-19 in patients with systemic lupus erythematosus (SLE) remains challenging, particularly considering drug-drug interactions (DDIs).
Chenxiao Jiang +9 more
doaj +1 more source
Journal of Analytical Methods in Chemistry, 2018 Phenytoin (PHT) is one of the most often used critical dose drugs, where insufficient or excessive dosing can have severe consequences such as seizures or toxicity.
Raphael Hösli +2 more
doaj +1 more source
Pharmacology, Medicinal Chemistry, and Therapeutic Potential of Imidazoline Receptor Ligands
ChemMedChem, Volume 21, Issue 13, 14 July 2026.Building on the excellent review article by Dardonville and Rozas (2004), this paper summarizes the most representative ligands of imidazoline receptors (IR; I1, I2, and I3) and updates their pharmacological profiles. Although not exhaustive, it provides a solid starting point for understanding the significance of I2 IRs as promising therapeutic ...
Maria‐Eleni Kouridaki +2 more
wiley +1 more source
Indian Journal of Health Sciences and Biomedical Research KLEU, 2016 Background: The aim of the present study was to develop a polyherbal formulation for epilepsy. Present polyherbal formulation (PHF) (containing Operculina turpethum (L.) Silva Manso, Mimosa pudica L., Uraria picta (Jacq.) DC., Cajanus cajan (L.) Millsp ...
Arka Ghosh +3 more
doaj +1 more source
Case Report - Severe phenytoin toxicity in a CYP2C9*3*3 homozygous mutant from India [PDF]
, 2007 The authors report an Indian adult female patient with a history of generalized tonic clonic seizures who developed severe features of phenytoin (DPH) toxicity on therapeutic dosage of this antiepileptic drug.
Ramasamy, Kesavan +3 more
core +2 more sources