Results 91 to 100 of about 10,598 (216)

Quantitative prediction of intravenous drug interactions caused by cytochromes P450 inhibitors and inducers

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2682-2692, August 2026.
Background Aims Pharmacokinetic interaction studies typically focus on oral administration, but intravenous (IV) administration bypasses intestinal degradation and hepatic first‐pass metabolism, leading to distinct drug–drug interaction (DDI) magnitude. This study aimed to develop a predictive model for DDIs involving IV‐administered drugs.
Vianney Tuloup, Michel Tod, Laurent Bourguignon   +2 more
wiley   +1 more source

Interaction of azapropazone with phenytoin. [PDF]

, 1982
We recently observed a patient in whom we suspected an interaction of azapropazone with phenytoin resulting in phenytoin toxicity. This and a report of a similar case led us to investigate the effect of azapropazone on steady-state plasma phenytoin ...
Carver, JG, Warlow, CP, Geaney, DP, Aronson, JK, Aronson, Jeffrey   +4 more
core  

Sodium Valproate Toxicity in Emergency Department Patients: A Retrospective Study from a Tertiary Academic Hospital

Current Medical Issues
Background: Sodium valproate (SV) overdose primarily causes central nervous system depression and metabolic disturbances. The objective of this study was to describe the clinical characteristics and outcomes of patients presenting with SV toxicity to the
Enas Hamid Alkhanjari, Darpanarayan Hazra, Suad Abdullah Al Abri   +2 more
doaj   +1 more source

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2723-2740, August 2026.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga, Stefano Agliardi, Riccardo Giossi, Alice Schianchi, Alessandra Romandini, Thomas Virdis, Silvia Nerini Molteni, Maria Luisa De Angelis, Stefania Paccagnini, Cecilia Gechtman, Alice Proto, Marco Fossati, Silvia Oliveri, Giulia Angela Pattarino, Elena Altieri, Agnese Graziosi, Arianna Pani, Romano Danesi, Stefano Martinelli, Costantino De Giacomo, Francesco Scaglione   +20 more
wiley   +1 more source

Phenytoin toxicity presenting with acute visual loss and acute delirium, a case report [PDF]

, 2018
Phenytoin is a widely prescribed antiepileptic agent for both focal and generalized seizure. We report a case of a 20-year-old man with focal epilepsy presented with acute bilateral visual loss, and delirium.
Chew, Sin Hong, Looi, Irene, Lo, Yoke Lin, Lim, Kheng Seang   +3 more
core  

Endogenous melatonin partial metabolic clearance as a potential endogenous marker of CYP1A2 activity

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2899-2908, August 2026.
Aims Cytochrome P450 1A2 (CYP1A2) exhibits substantial interindividual variability, necessitating appropriate phenotyping strategies for personalized pharmacotherapy. This study evaluated endogenous melatonin partial metabolic clearance (CLm(MEL)), calculated from urinary 6‐hydroxymelatonin (6‐O‐MEL) excretion and plasma melatonin (MEL) exposure, as a ...
Akitomo Yokokawa, Hayato Shimazaki, Shunji Igarashi, Yoshiki Tagawa, Naoki Hisada, Hiromi Shibasaki   +5 more
wiley   +1 more source

Life-threatening cardiotoxicity due to chronic oral phenytoin overdose [PDF]

, 2009
Severe cardiac adverse effects are often related to intravenous phenytoin overdose. However, there is no reported cardiotoxicity resulting from oral overdose of phenytoin.
Su, Chih-Min, Kung, Chia-Te, Lu, Cheng-Hsien, Wang, Yu-Chin   +3 more
core   +3 more sources

Practice parameters in management of status epileptics

Annals of Indian Academy of Neurology, 2014
Status epilepticus (SE) is an emergency neurological problem, more common in the developing countries due to high incidence of infection, stroke and head injury.
Usha Kant Misra, Jayantee Kalita, Sanjeev Kumar Bhoi   +2 more
doaj   +1 more source

Acute Encephalopathy in a Patient With Chronic Isotretinoin Exposure and Frequent Rizatriptan Use: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Acute encephalopathy in patients with prolonged isotretinoin exposure should prompt careful assessment of undisclosed or non‐prescribed medication use. This case suggests a possible association between high cumulative isotretinoin exposure, frequent daily rizatriptan use, and acute encephalopathy, but does not establish a definitive drug–drug ...
Soheil Roshanzamiri, Mitra Rahimi, Shahin Shadnia, Peyman Erfantalab Evini, Faraz Zandiyeh, Babak Mostafazadeh   +5 more
wiley   +1 more source

Development of UPLC–MS/MS method for the simultaneous quantification of valproic acid and phenytoin in human plasma and application to study pharmacokinetic interaction in epilepsy patients

Heliyon
Valproic acid and phenytoin are two prevalent antiepileptic medications known for their narrow indices and propensity for cardiovascular and respiratory system toxicity.
Sil Thanh Nguyen, Duy Nguyen Ho, Thi Anh Huynh Huynh, Huyen Thu Thi Nguyen, Ngan Kim Thi Ly, Minh Van Le, Tho Vinh Minh Chau Do   +6 more
doaj   +1 more source