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Indian pediatrics, 1993 Some of the next articles are maybe not open access.
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Phenytoin toxicity from smoking crack cocaine adulterated with phenytoin
Annals of Emergency Medicine, 1993Drugs of abuse often are adulterated with agents designed to lower cost or alter the intoxication. Recently, we began to hear of the intentional addition of phenytoin to crack cocaine. We report the cases of five patients with measurable phenytoin levels attributable to smoking crack cocaine adulterated with phenytoin. Three of these patients presented
Robert S Hoffman, Robert A Silverman
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Phenytoin Toxicity Due to Genetic Polymorphism
Neurocritical Care, 2008Patients with traumatic brain injury commonly receive phenytoin for seizure prophylaxis. Due to the non-linear pharmacokinetics of phenytoin and narrow therapeutic window, phenytoin concentrations are monitored to ensure efficacy and prevent toxicity. Because phenytoin is hepatically metabolized, polymorphisms within cytochrome P450 enzymes can affect ...
Stacy A Voils
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The American Journal of Emergency Medicine, 2014
Phenytoin has a narrow therapeutic window, and when managing cases of toxicity, clinicians are very wary of this fact. Typically, if patient presents with symptoms suggestive of phenytoin toxicity, total serum phenytoin is promptly ordered. That could be falsely low especially in elderly or critically ill patients, which may lead to a low albumin level
Syed Haider, Imam +5 more
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Phenytoin has a narrow therapeutic window, and when managing cases of toxicity, clinicians are very wary of this fact. Typically, if patient presents with symptoms suggestive of phenytoin toxicity, total serum phenytoin is promptly ordered. That could be falsely low especially in elderly or critically ill patients, which may lead to a low albumin level
Syed Haider, Imam +5 more
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Incidence of seizures with phenytoin toxicity
Neurology, 1985Among 50 patients with phenytoin intoxication, 14 had seizures during the episode. Seizures in 9 of these 14 patients probably resulted from poor seizure control despite high phenytoin levels, but in 5 cases, attacks were attributed to phenytoin toxicity.
N, Stilman, J C, Masdeu
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Phenytoin Toxicity Secondary to an Oxcarbazepine-Phenytoin 2C19 Interaction
Psychosomatics, 2010Polytherapy is common in the management of bipolar disorder, as are the side effects associated with this treatment strategy.The authors review the literature on drug-drug interactions involving oxcarbazepine and identify specific mechanisms that may have clinical importance.The authors provide a case report of a patient who developed phenytoin ...
David P, Soskin +2 more
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Otolaryngologic manifestations of phenytoin toxicity
Clinical Otolaryngology, 1992DPH may result in protean head and neck manifestations (Table 1). In some cases these effects are dose related and in others they appear to be idiosyncratic; some occur only at toxic levels (Table 2). Many of the conditions are reversible and withdrawal of DPH or re-establishment of therapeutic levels is the only treatment necessary.
G, Grillone, D, Myssiorek
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Elimination of phenytoin in toxic overdose
Clinical Neurology and Neurosurgery, 2000Phenytoin is widely used for the management of seizures. Fortunately overdosage with this drug is rare. We performed a prospective study to investigate the elimination kinetics of phenytoin in toxic overdose. All patients were only on phenytoin and not on other anticonvulsants.
H C, Chua +3 more
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Phenytoin Therapy and Toxicities
Annals of Internal Medicine, 1984Excerpt To the editor: Many clinicians and patients will benefit from Dr. Troupin's lucid guidelines on when to measure anticonvulsant drug plasma concentrations (1).
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SPASTICITY DUE TO PHENYTOIN TOXICITY
Medical Journal of Australia, 1979A young epileptic presented with spasticity as well as ataxia, diplopia and nystagmus; his serum phenytoin level was very high. All the abnormal signs disappeared after withdrawal of phenytoin. Spasticity, hyperreflexia, and clonus are features of phenytoin intoxication, present in this case, which are not commonly seen, and which have rarely been ...
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