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The American Journal of Emergency Medicine, 2014
Phenytoin has a narrow therapeutic window, and when managing cases of toxicity, clinicians are very wary of this fact. Typically, if patient presents with symptoms suggestive of phenytoin toxicity, total serum phenytoin is promptly ordered. That could be falsely low especially in elderly or critically ill patients, which may lead to a low albumin level
Syed Haider, Imam +5 more
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Phenytoin has a narrow therapeutic window, and when managing cases of toxicity, clinicians are very wary of this fact. Typically, if patient presents with symptoms suggestive of phenytoin toxicity, total serum phenytoin is promptly ordered. That could be falsely low especially in elderly or critically ill patients, which may lead to a low albumin level
Syed Haider, Imam +5 more
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Phenytoin-Induced Toxic Epidermal Necrolysis
Annals of Internal Medicine, 1979Excerpt Toxic epidermal necrolysis is one of the most severe adverse reactions to a drug. A mortality rate of approximately 25% has been reported (1, 2).
L E, Gately, M A, Lam
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Otolaryngologic manifestations of phenytoin toxicity
Clinical Otolaryngology, 1992DPH may result in protean head and neck manifestations (Table 1). In some cases these effects are dose related and in others they appear to be idiosyncratic; some occur only at toxic levels (Table 2). Many of the conditions are reversible and withdrawal of DPH or re-establishment of therapeutic levels is the only treatment necessary.
G, Grillone, D, Myssiorek
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Fluconazole-Induced Symptomatic Phenytoin Toxicity
Annals of Pharmacotherapy, 1994OBJECTIVE:To report two cases of fluconazole-induced symptomatic phenytoin toxicity and review literature related to this interaction.DATA SOURCES:Case reports and review articles identified by a computerized (MEDLINE) and manual ( Index Medicus) search.DATA SYNTHESIS:Fluconazole is a broad-spectrum triazole antifungal agent primarily eliminated by ...
R M, Cadle +3 more
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Phenytoin Toxicity Secondary to an Oxcarbazepine-Phenytoin 2C19 Interaction
Psychosomatics, 2010Polytherapy is common in the management of bipolar disorder, as are the side effects associated with this treatment strategy.The authors review the literature on drug-drug interactions involving oxcarbazepine and identify specific mechanisms that may have clinical importance.The authors provide a case report of a patient who developed phenytoin ...
David P, Soskin +2 more
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Phenytoin toxicity from smoking crack cocaine adulterated with phenytoin
Annals of Emergency Medicine, 1993Drugs of abuse often are adulterated with agents designed to lower cost or alter the intoxication. Recently, we began to hear of the intentional addition of phenytoin to crack cocaine. We report the cases of five patients with measurable phenytoin levels attributable to smoking crack cocaine adulterated with phenytoin. Three of these patients presented
A A, Katz, R S, Hoffman, R A, Silverman
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Phenytoin Therapy and Toxicities
Annals of Internal Medicine, 1984Excerpt To the editor: Many clinicians and patients will benefit from Dr. Troupin's lucid guidelines on when to measure anticonvulsant drug plasma concentrations (1).
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