Results 131 to 140 of about 10,045 (177)

Ticlopidine-Induced Phenytoin Toxicity

Annals of Pharmacotherapy, 1998
OBJECTIVE: To report a probable case of ticlopidine-induced phenytoin toxicity. CASE SUMMARY: A 72-year-old man suddenly developed combative behavior, refused to leave his room, stopped eating, and began falling to the floor 6 weeks after being given ticlopidine.
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Incidence of seizures with phenytoin toxicity

Neurology, 1985
Among 50 patients with phenytoin intoxication, 14 had seizures during the episode. Seizures in 9 of these 14 patients probably resulted from poor seizure control despite high phenytoin levels, but in 5 cases, attacks were attributed to phenytoin toxicity.
N, Stilman, J C, Masdeu
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Phenytoin Toxicity Due to Genetic Polymorphism

Neurocritical Care, 2008
Patients with traumatic brain injury commonly receive phenytoin for seizure prophylaxis. Due to the non-linear pharmacokinetics of phenytoin and narrow therapeutic window, phenytoin concentrations are monitored to ensure efficacy and prevent toxicity. Because phenytoin is hepatically metabolized, polymorphisms within cytochrome P450 enzymes can affect ...
Lauren K, McCluggage, Stacy A, Voils, Malcolm Ross, Bullock   +2 more
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SPASTICITY DUE TO PHENYTOIN TOXICITY

Medical Journal of Australia, 1979
A young epileptic presented with spasticity as well as ataxia, diplopia and nystagmus; his serum phenytoin level was very high. All the abnormal signs disappeared after withdrawal of phenytoin. Spasticity, hyperreflexia, and clonus are features of phenytoin intoxication, present in this case, which are not commonly seen, and which have rarely been ...
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Elimination of phenytoin in toxic overdose

Clinical Neurology and Neurosurgery, 2000
Phenytoin is widely used for the management of seizures. Fortunately overdosage with this drug is rare. We performed a prospective study to investigate the elimination kinetics of phenytoin in toxic overdose. All patients were only on phenytoin and not on other anticonvulsants.
H C, Chua, N, Venketasubramanian, H, Tjia, S P, Chan   +3 more
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Phenytoin Toxicity and Hepatic Encephalopathy

Journal of Clinical Gastroenterology, 1987
Two cases of phenytoin toxicity in patients with chronic liver disease who were taking 300 mg phenytoin daily are described. Each patient developed encephalopathy, characterized by confusion, disturbed conscious state, asterixis, and nystagmus, which was resistant to treatment with protein restriction, lactulose, and neomycin, but responsive to ...
N L, Sandford, N, Murray, A J, Keyser, T B, Reynolds   +3 more
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Athetosis and Phenytoin Toxicity

Archives of Pediatrics & Adolescent Medicine, 1977
Sir.—We were interested in the case report by Zinsmeister and Marks (Am J Dis Child130:75, 1976) of a child in whom acute athetosis in association with phenytoin toxicity developed. We are prompted to pass comment on these authors' observations, as we have recently encountered a similar clinical problem.
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Fatal Phenytoin-Related Toxic Epidermal Necrolysis: Case Report

Neurosurgery, 1989
Abstract Toxic epidermal necrolysis is a rare but often fatal hypersensitivity reaction to numerous agents, including most anticonvulsants. The authors present a case of fatal phenytoin-related toxic epidermal necrolysis in a patient who was given prophylactic anticonvulsant therapy after he sustained a moderately severe closed head ...
D F, Kelly, D G, Hope
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Phenytoin Toxicity with Associated Meningeal Reaction

Journal of Mental Science, 1958
Phenytoin Sodium (Sodium diphenylhydantoinate) is established in the treatment of epilepsy. Toxic side effects, especially on the nervous system, have been well documented. Untoward reactions may follow therapeutic doses taken over a period of time, or as the result of a single massive dose taken accidentally or with suicidal intent.The following case ...
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Phenytoin Toxicity and Co-trimoxazole

Annals of Internal Medicine, 1985
Excerpt To the editor: Phenytoin has been shown to interact with a number of drugs to cause toxicity (1).
M. A. GILLMAN, R. SANDYK
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