Results 151 to 160 of about 621,544 (210)

Anticonvulsant Potential and Network Pharmacology Analysis of Pimenta dioica (L.) Merr. [PDF]

Chem Biodivers
Manal D, Sahana, Saidarshan RP, Sandhya M, Soham B, Suman C, Mohamed Shabi M, Nair G, Karthik Kumar B, Sundara Saravanan K.   +9 more
europepmc   +1 more source

Acute Encephalopathy in a Patient With Chronic Isotretinoin Exposure and Frequent Rizatriptan Use: A Case Report. [PDF]

Clin Case Rep
Roshanzamiri S, Rahimi M, Shadnia S, Erfantalab Evini P, Zandiyeh F, Mostafazadeh B.   +5 more
europepmc   +1 more source

Phenytoin Toxicity Due to Genetic Polymorphism

Neurocritical Care, 2008
Patients with traumatic brain injury commonly receive phenytoin for seizure prophylaxis. Due to the non-linear pharmacokinetics of phenytoin and narrow therapeutic window, phenytoin concentrations are monitored to ensure efficacy and prevent toxicity. Because phenytoin is hepatically metabolized, polymorphisms within cytochrome P450 enzymes can affect ...
Lauren K, McCluggage, Stacy A, Voils, Malcolm Ross, Bullock   +2 more
openaire   +3 more sources

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Free phenytoin toxicity

The American Journal of Emergency Medicine, 2014
Phenytoin has a narrow therapeutic window, and when managing cases of toxicity, clinicians are very wary of this fact. Typically, if patient presents with symptoms suggestive of phenytoin toxicity, total serum phenytoin is promptly ordered. That could be falsely low especially in elderly or critically ill patients, which may lead to a low albumin level
Syed Haider, Imam, Kristen, Landry, Viren, Kaul, Harvir, Gambhir, Dinesh, John, Brian, Kloss   +5 more
openaire   +2 more sources

Incidence of seizures with phenytoin toxicity

Neurology, 1985
Among 50 patients with phenytoin intoxication, 14 had seizures during the episode. Seizures in 9 of these 14 patients probably resulted from poor seizure control despite high phenytoin levels, but in 5 cases, attacks were attributed to phenytoin toxicity.
N, Stilman, J C, Masdeu
openaire   +3 more sources

Phenytoin Toxicity Secondary to an Oxcarbazepine-Phenytoin 2C19 Interaction

Psychosomatics, 2010
Polytherapy is common in the management of bipolar disorder, as are the side effects associated with this treatment strategy.The authors review the literature on drug-drug interactions involving oxcarbazepine and identify specific mechanisms that may have clinical importance.The authors provide a case report of a patient who developed phenytoin ...
David P, Soskin, Ari J, Kane, Theodore A, Stern   +2 more
openaire   +2 more sources

Otolaryngologic manifestations of phenytoin toxicity

Clinical Otolaryngology, 1992
DPH may result in protean head and neck manifestations (Table 1). In some cases these effects are dose related and in others they appear to be idiosyncratic; some occur only at toxic levels (Table 2). Many of the conditions are reversible and withdrawal of DPH or re-establishment of therapeutic levels is the only treatment necessary.
G, Grillone, D, Myssiorek
openaire   +2 more sources

Elimination of phenytoin in toxic overdose

Clinical Neurology and Neurosurgery, 2000
Phenytoin is widely used for the management of seizures. Fortunately overdosage with this drug is rare. We performed a prospective study to investigate the elimination kinetics of phenytoin in toxic overdose. All patients were only on phenytoin and not on other anticonvulsants.
H C, Chua, N, Venketasubramanian, H, Tjia, S P, Chan   +3 more
openaire   +2 more sources