Results 161 to 170 of about 621,544 (210)
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Phenytoin Therapy and Toxicities
Annals of Internal Medicine, 1984Excerpt To the editor: Many clinicians and patients will benefit from Dr. Troupin's lucid guidelines on when to measure anticonvulsant drug plasma concentrations (1).
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Phenytoin toxicity from smoking crack cocaine adulterated with phenytoin
Annals of Emergency Medicine, 1993Drugs of abuse often are adulterated with agents designed to lower cost or alter the intoxication. Recently, we began to hear of the intentional addition of phenytoin to crack cocaine. We report the cases of five patients with measurable phenytoin levels attributable to smoking crack cocaine adulterated with phenytoin. Three of these patients presented
A A, Katz, R S, Hoffman, R A, Silverman
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SPASTICITY DUE TO PHENYTOIN TOXICITY
Medical Journal of Australia, 1979A young epileptic presented with spasticity as well as ataxia, diplopia and nystagmus; his serum phenytoin level was very high. All the abnormal signs disappeared after withdrawal of phenytoin. Spasticity, hyperreflexia, and clonus are features of phenytoin intoxication, present in this case, which are not commonly seen, and which have rarely been ...
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Phenytoin Toxicity and Hepatic Encephalopathy
Journal of Clinical Gastroenterology, 1987Two cases of phenytoin toxicity in patients with chronic liver disease who were taking 300 mg phenytoin daily are described. Each patient developed encephalopathy, characterized by confusion, disturbed conscious state, asterixis, and nystagmus, which was resistant to treatment with protein restriction, lactulose, and neomycin, but responsive to ...
N L, Sandford +3 more
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Phenytoin toxicity due to interaction‐ with clobazam
Neurology, 1991The benzodiazepine antiepileptic drug clobazam can be added to existing AED treatment, usually without clinical toxicity. We report 3 patients in whom the addition of clobazam led within several weeks to clinically obvious phenytoin (PHT) intoxication in patients who had been taking maximum tolerable PHT doses.
B, Zifkin, A, Sherwin, F, Andermann
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Ticlopidine-Induced Phenytoin Toxicity
Annals of Pharmacotherapy, 1998OBJECTIVE: To report a probable case of ticlopidine-induced phenytoin toxicity. CASE SUMMARY: A 72-year-old man suddenly developed combative behavior, refused to leave his room, stopped eating, and began falling to the floor 6 weeks ...
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Phenytoin-Induced Toxic Epidermal Necrolysis
Annals of Internal Medicine, 1979Excerpt Toxic epidermal necrolysis is one of the most severe adverse reactions to a drug. A mortality rate of approximately 25% has been reported (1, 2).
L E, Gately, M A, Lam
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Athetosis and Phenytoin Toxicity
Archives of Pediatrics & Adolescent Medicine, 1977Sir.—We were interested in the case report by Zinsmeister and Marks (Am J Dis Child130:75, 1976) of a child in whom acute athetosis in association with phenytoin toxicity developed. We are prompted to pass comment on these authors' observations, as we have recently encountered a similar clinical problem.
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Fluconazole-Induced Symptomatic Phenytoin Toxicity
Annals of Pharmacotherapy, 1994OBJECTIVE: To report two cases of fluconazole-induced symptomatic phenytoin toxicity and review literature related to this interaction. DATA SOURCES: Case reports and review articles identified by a computerized (MEDLINE) and manual ...
R M, Cadle +3 more
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Hypothyroxinemia and Phenytoin Toxicity: A Vicious Circle
Drug Metabolism and Drug Interactions, 1996Phenytoin is a widely used anticonvulsant which has a relatively narrow therapeutic range of serum concentrations, 40-80 mmol/l (10-20 mg/l). Phenytoin is known to show concentration-dependent kinetics within this therapeutic range. Because of this, small changes in dose and minor alterations in hepatic metabolism of phenytoin may cause a ...
T C, Sarich, J M, Wright
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