Results 1 to 10 of about 1,554 (110)

Progranulin-driven lysosomal acidification facilitates exocytosis of PHEV-hijacked lysosomes for viral release [PDF]

mBio
Porcine hemagglutinating encephalomyelitis virus (PHEV) hijacks lysosomes, repurposing them as vehicles for viral release by disrupting their function. Progranulin (PGRN), a lysosomal glycoprotein essential for lysosomal regulation, plays a pivotal role ...
Zhenzhen Wang, Yuzhu Chen, Wenqi He, Yuzhu Liu, Yubo Jiao, Gaili Wang, Jiyu Guan, Kui Zhao, Qiaoling Zhang, Feng Gao, Zi Li, Yungang Lan   +11 more
doaj   +2 more sources

Porcine hemagglutinating encephalomyelitis virus VW572 (not Gent/PS412 and Labadie) uses the CD81 receptor and MVB-derived exosomal pathway for efficient entry and spread in neuronal cells [PDF]

Journal of Virology
Porcine hemagglutinating encephalomyelitis virus (PHEV) is considered a neurotropic coronavirus that invades the peripheral (PNS) and central (CNS) nervous system of the pig and causes acute encephalomyelitis, also known as “vomiting and wasting disease.”
W. Zaib, C. Kaviani, X. Kang, Y. Gao, F. Vanden Broucke, W. Van den Broeck, S. Coppens, S. Theuns, H. Nauwynck, K. Laval   +9 more
doaj   +2 more sources

Seroprevalence of coronaviruses of cattle and pigs in Belgian herds [PDF]

BMC Veterinary Research
Background Bovine coronavirus (BCoV), porcine haemagglutinating encephalomyelitis virus (PHEV), and porcine respiratory coronavirus (PRCV) are common coronaviruses of cattle and swine, but they are rarely monitored.
Ruth M. Mumo, Stefaan Ribbens, Fabien Grégoire, Sebastiaan Theuns, Bart Pardon, Kristien Van Reeth   +5 more
doaj   +2 more sources

Porcine coronavirus promotes NLRP3 inflammasome activation during virus-induced neuroinflammation [PDF]

mBio
Neurotropic coronaviruses can invade the central nervous system (CNS) and cause severe neurological disease, but the mechanisms underlying virus-induced neuroinflammation remain incompletely understood.
Qianyu Zhou, Junchao Shi, Ruizhao Qiu, Rui Dai, Yungang Lan, Jiyong Zhou, Xuming Deng, Wenqi He, Zi Li   +8 more
doaj   +2 more sources

Porcine hemagglutinating encephalomyelitis virus nucleocapsid protein targets RIG-I and IRF3 to evade IFN immunity [PDF]

Journal of Virology
The neurotropic betacoronavirus porcine hemagglutinating encephalomyelitis virus (PHEV) subverts early innate defenses to establish persistent neuronal infection.
Shaoqian Mu, Yuanmao Bai, Ruizhao Qiu, Feilin Zhang, Junchao Shi, Yungang Lan, Feng Gao, Wenqi He, Zi Li   +8 more
doaj   +2 more sources

Evolution of the pheV-tRNA integrated genomic island in Escherichia coli. [PDF]

PLoS Genetics
Escherichia coli exhibit extensive genetic diversity at the genome level, particularly within their accessory genome. The tRNA integrated genomic islands (GIs), a part of the E. coli accessory genome, play an important role in pathogenicity.
Nguyen Thi Khanh Nhu, Brian M Forde, Nouri L Ben Zakour, Minh-Duy Phan, Leah W Roberts, Scott A Beatson, Mark A Schembri   +6 more
doaj   +2 more sources

Genetic diversity and evolution of porcine hemagglutinating encephalomyelitis virus in Guangxi province of China during 2021–2024 [PDF]

Frontiers in Microbiology
Porcine hemagglutinating encephalomyelitis virus (PHEV) is the only known porcine neurotropic coronavirus, which is prevalent worldwide at present. It is of great significance to understand the genetic and evolutionary characteristics of PHEV in order to
Kaichuang Shi, Kaichuang Shi, Kaichuang Shi, Xin Hu, Feng Long, Yuwen Shi, Yi Pan, Shuping Feng, Zongqiang Li, Yanwen Yin   +9 more
doaj   +2 more sources

Genetic and Antigenic Characterization of Bovine and Porcine Respiratory Coronaviruses Circulating in Western Europe, 2020–2023 [PDF]

Viruses
The 2019 coronavirus disease pandemic (COVID-19) showed how genetic mutations can alter coronavirus characteristics. However, the evolution of livestock coronaviruses remains understudied.
Ruth M. Mumo, Anna Parys, Sieglinde Coppens, Nick Vereecke, Sebastiaan Theuns, Bart Pardon, Kristien Van Reeth   +6 more
doaj   +2 more sources

DNA vaccine targeting betacoronavirus spike protein blocks neuroinvasion and neuroinflammation in swine via dual antiviral-immunomodulatory action [PDF]

npj Vaccines
Porcine hemagglutinating encephalomyelitis virus (PHEV), a neurotropic betacoronavirus, causes fatal neurological disease in piglets, yet no licensed vaccines exist.
Huabo Yu, Junchao Shi, Guoce Fu, Zezhao Cao, Ruizhao Qiu, Tianqi Zhao, Jing Zhang, Yungang Lan, Jiyu Guan, Kui Zhao, Feng Gao, Wenqi He, Zi Li   +12 more
doaj   +2 more sources

Development of a triplex crystal digital RT-PCR for the detection of PHEV, PRV, and CSFV [PDF]

Frontiers in Veterinary Science
Porcine hemagglutinating encephalomyelitis virus (PHEV), porcine pseudorabies virus (PRV), and classical swine fever virus (CSFV) are currently prevalent worldwide and cause similar neurological symptoms in infected pigs.
Kaichuang Shi, Kaichuang Shi, Kaichuang Shi, Xin Hu, Yanwen Yin, Yuwen Shi, Yi Pan, Feng Long, Shuping Feng, Zongqiang Li   +9 more
doaj   +2 more sources