Results 211 to 220 of about 8,290 (226)

Supplementary Fig.S8 from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer

Takehiro Yamamoto, Tetsu Hayashida, Yohei Masugi, Kiyotaka Oshikawa, Noriyo Hayakawa, Mai Itoh, Chiyoko Nishime, Masami Suzuki, Aiko Nagayama, Yuko Kawai, Takako Hishiki, Tomomi Matsuura, Yoshiko Naito, Akiko Kubo, Arisa Yamamoto, Yujiro Yoshioka, Tomokazu Kurahori, Misa Nagasaka, Minako Takizawa, Naoharu Takano, Koji Kawakami, Michiie Sakamoto, Masatoshi Wakui, Takushi Yamamoto, Yuko Kitagawa, Yasuaki Kabe, Kenichi Horisawa, Atsushi Suzuki, Masaki Matsumoto, Makoto Suematsu   +29 more
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Biophysical and biochemical properties of PHGDH revealed by studies on PHGDH inhibitors

Cellular and Molecular Life Sciences, 2021
The rate-limiting serine biogenesis enzyme PHGDH is overexpressed in cancers. Both serine withdrawal and genetic/pharmacological inhibition of PHGDH have demonstrated promising tumor-suppressing activities. However, the enzyme properties of PHGDH are not well understood and the discovery of PHGDH inhibitors is still in its infancy.
Yuping Tan, Xia Zhou, Yanqiu Gong, Kun Gou, Youfu Luo, Da Jia, Lunzhi Dai, Yinglan Zhao, Qingxiang Sun   +8 more
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Abstract 3014: PHGDH- A therapeutic vulnerability in melanoma

Cancer Research, 2022
Abstract Recurrently amplified oncogenes may represent melanoma vulnerabilities that can be exploited for therapy. The genomic locus containing the Phosphoglycerate Dehydrogenase (PHGDH) gene at chromosome 1p12 is frequently amplified in melanoma.
Neel N. Jasani, Florian Karreth
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Phosphoglycerate dehydrogenase (PHGDH) deficiency without epilepsy mimicking primary microcephaly

American Journal of Medical Genetics Part A, 2017
Phosphoglycerate dehydrogenase (PHGDH) deficiency (OMIM 256520) is a rare autosomal recessive disorder of serine synthesis, with mostly severe congenital microcephaly, caused by mutations in the PHGDH gene. Fourteen patients reported to date show severe, early onset, drug resistant epilepsy.
Antoine Poli, Yoann Vial, Damien Haye, Sandrine Passemard, Manuel Schiff, Hala Nasser, Catherine Delanoe, Emma Cuadro, Rémi Kom, Narcisse Elanga, Anne Favre, Séverine Drunat, Alain Verloes   +12 more
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Glycolysis-derived L-serine levels versus PHGDH expression in Alzheimer’s disease

Cell Metabolism, 2022
Recent work from Bonvento and colleagues indicated that synaptic and memory deficits in early Alzheimer's disease (AD) are related to a shortage in L-serine production in astrocytes. Here, the authors, responding to correspondence from Chen and colleagues, discuss how this deficiency does not necessarily require a decrease in PHGDH expression and ...
Bonvento, Gilles, Oliet, Stéphane H.R., Panatier, Aude   +2 more
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PHGDH amplification and altered glucose metabolism in human melanoma

Pigment Cell & Melanoma Research, 2011
SummaryThe metabolic requirements of cancer cells differ from that of their normal counterparts. To support their proliferation, cancer cells switch to a fermentative metabolism that is thought to support biomass production. Instances where metabolic enzymes promote tumorigenesis remain rare.
Edouard, Mullarky, Katherine R, Mattaini, Matthew G, Vander Heiden, Lewis C, Cantley, Jason W, Locasale   +4 more
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PHGDH Inhibition Overcomes Glioblastoma Resistance to T-cell Therapy

Cancer Discovery, 2023
Abstract Phosphoglycerate dehydrogenase (PHGDH) inhibition improves T-cell therapy efficacy in glioblastoma.
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A retrospective overview of PHGDH and its inhibitors for regulating cancer metabolism

European Journal of Medicinal Chemistry, 2021
Emerging evidence suggests that cancer metabolism is closely associated to the serine biosynthesis pathway (SSP), in which glycolytic intermediate 3-phosphoglycerate is converted to serine through a three-step enzymatic transformation. As the rate-limiting enzyme in the first step of SSP, phosphoglycerate dehydrogenase (PHGDH) is overexpressed in ...
Jia-Ying Zhao, Kai-Rui Feng, Feng Wang, Jian-Wei Zhang, Jay Fei Cheng, Guo-Qiang Lin, Dingding Gao, Ping Tian   +7 more
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Increased Expression of PHGDH Under High-Selenium Stress In Vivo

Biological Trace Element Research
The purpose of this study is to explore the glycolytic remodeling under high-selenium (Se) stress. Three groups of male C57BL/6J mice were fed on diets with different Se contents (0.03, 0.15, and 0.30 mg Se/kg). Glucose tolerance test (GTT) and insulin tolerance test (ITT) were measured at the third month. Mice were killed at the fourth month.
Qin, Wang, Jianrong, Wang, Xue, Zhang, Yiqun, Liu, Feng, Han, Xuesong, Xiang, Yanbin, Guo, Zhen-Wu, Huang   +7 more
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