Results 11 to 20 of about 74,576 (156)

Molecular Cytogenetics Investigation of the Telomeres in a Case of Philadelphia Positive B-ALL with a Single Telomere Expansion

Neoplasia: An International Journal for Oncology Research, 1999
We have investigated a single telomere expansion in a case of acute lymphoblastic B-cell leukemia (B-ALL), where half of the cells in the bone marrow sample appeared with a Philadelphia chromosome. Comparing telomere sizes in Philadelphia-positive versus
Katerina Krejcí, Jesper Stentof, Jørn Koch   +2 more
doaj   +1 more source

How I diagnose and manage Philadelphia chromosome-like acute lymphoblastic leukemia

Haematologica, 2019
Advances in our understanding of mechanisms of leukemogenesis and driver mutations in acute lymphoblastic leukemia (ALL) lead to a more precise and informative sub-classification, mainly of B-cell ALL. In parallel, in recent years, novel agents have been
Avraham Frisch, Yishai Ofran
doaj   +1 more source

Evaluation of Common Genetic Disorders in Myeloproliferative Neoplasms [PDF]

International Journal of Hematology-Oncology and Stem Cell Research, 2011
Introduction: The myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by excessive production of blood cells by  hematopoietic precursors. Typically, they include polycythemia vera (PV), essential thrombocythemia (ET),
Mehrdad Payandeh, Farhad Shaveisi Zadeh, Mohammad Erfan Zare, Kamran Mansouri, Reza Khodarahmi, Saeed Alimoradi, Hoshang Yousefi, Fatemeh Darabi   +7 more
doaj   +1 more source

Bilateral Serous Retinal Detachment in Lymphoid Blast Crisis of Chronic Myeloid Leukemia

Case Reports in Ophthalmology, 2021
We herein report a patient with Philadelphia chromosome-positive lymphoid blast crisis of chronic myeloid leukemia (CML), who presented with bilateral serous retinal detachment (SRD).
Kyohei Umemura, Kyoko Fujita, Akiko Jinno, Ayano Nakamura, Motohiro Kamei   +4 more
doaj   +1 more source

Pediatric Philadelphia-positive B lymphoblastic leukemia with CD56 expression and L2 morphology: Case report and review of the literature

Human Pathology: Case Reports, 2017
We present a unique case of pediatric B lymphoblastic leukemia with Philadelphia chromosome, CD56 expression, and predominantly L2 morphology. A review of the current literature demonstrates that this distinct combination of features is rare and may ...
Jadee Neff, MD, PhD, Dong Chen, MD, PhD
doaj   +1 more source

p185BCR/ABL has a lower sensitivity than p210BCR/ABL to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia

Haematologica, 2012
Background The t(9;22) translocation leads to the formation of the chimeric breakpoint cluster region/c-abl oncogene 1 (BCR/ABL) fusion gene on der22, the Philadelphia chromosome. The p185BCR/ABL or the p210BCR/ABL fusion proteins are encoded as a result
Afsar A. Mian, Anna Metodieva, Yousef Najajreh, Oliver G. Ottmann, Jamal Mahajna, Martin Ruthardt   +5 more
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"Transformation of chronic myelogenous leukemia to Multiple Myeloma: A case report " [PDF]

Acta Medica Iranica, 2003
Chronic myelogenous leukemia (CML) is a stem cell disorder sometimes associated with lymphoproliferative disorders. CML may precede a lymphoproliferative disorder.
"Ghavamzadeh A, Alimoghaddam K, Mehdipour P, Sharifian R, Schwanitz G, Shamshiri AR "   +5 more
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A unique three-way Philadelphia chromosome variant t(4;9;22)(q21;q34;q11.2) in a newly diagnosed patient with chronic phase chronic myeloid leukemia: a case report and review of the literature

Journal of Medical Case Reports, 2021
Background Chronic myeloid leukemia is a hematologic malignancy associated with the fusion of two genes: BCR and ABL1. This fusion results from a translocation between chromosomes 9 and 22, which is called the Philadelphia chromosome.
Yuka Torii, Kana Nanjo, Tomomi Toubai, Masashi Hosokawa, Ryo Sato, Akane Yamada, Keiko Aizawa, Masahito Himuro, Satoshi Ito, Masakazu Yamamoto, John Magenau, Ryan Wilcox, Kenichi Ishizawa   +12 more
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Genetic Landscape of Myeloproliferative Neoplasms with an Emphasis on Molecular Diagnostic Laboratory Testing

Life, 2021
Chronic myeloproliferative neoplasms (MPNs) are hematopoietic stem cell neoplasms with driver events including the BCR-ABL1 translocation leading to a diagnosis of chronic myeloid leukemia (CML), or somatic mutations in JAK2, CALR, or MPL resulting in ...
Arti Easwar, Alexa J. Siddon
doaj   +1 more source

A Case of Philadelphia Chromosome Positive Myeloproliferative Neoplasm in a Pregnant Woman with Unusual Primary Myelofibrosis Features

Case Reports in Hematology, 2013
Myeloproliferative neoplasms (MPNs) are traditionally separated into BCR-ABL-positive chronic myeloid leukemia (CML), and BCR-ABL-negative MPNs including primary myelofibrosis (PMF), essential thrombocythemia (ET), and so forth.
Jason Koshy, Jack Alperin, Bagi Jana, Avi Markowitz, You-Wen Qian   +4 more
doaj   +1 more source