Results 11 to 20 of about 886,649 (291)

The Philadelphia chromosome in leukemogenesis [PDF]

Chinese Journal of Cancer, 2016
The truncated chromosome 22 that results from the reciprocal translocation t(9;22)(q34;q11) is known as the Philadelphia chromosome (Ph) and is a hallmark of chronic myeloid leukemia (CML). In leukemia cells, Ph not only impairs the physiological signaling pathways but also disrupts genomic stability.
L. Xu, Jiu Xing Feng, Jiu Xing Feng, Dan Huang, Yu Fei Liu, Yu Fei Liu, Yu Jia Pan, Yu Jia Pan, Ya Yang, Ya Yang, Zi Jie Long, Zhi Jie Kang, Zhi Jie Kang, Quentin Liu, Quentin Liu, Jinsong Yan, Bing Liu, Bing Liu   +17 more
doaj   +6 more sources

How I diagnose and manage Philadelphia chromosome-like acute lymphoblastic leukemia

Haematologica, 2019
Advances in our understanding of mechanisms of leukemogenesis and driver mutations in acute lymphoblastic leukemia (ALL) lead to a more precise and informative sub-classification, mainly of B-cell ALL. In parallel, in recent years, novel agents have been
Avraham Frisch, Yishai Ofran
doaj   +2 more sources

Ponatinib vs Imatinib in Frontline Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.

JAMA
Importance In newly diagnosed Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL), disease progression due to acquired resistance to first- or second-generation BCR::ABL1 tyrosine kinase inhibitors is common. Ponatinib inhibits BCR::
Jabbour E, Kantarjian HM, Aldoss I, Montesinos P, Leonard JT, Gómez-Almaguer D, Baer MR, Gambacorti-Passerini C, McCloskey J, Minami Y, Papayannidis C, Rocha V, Rousselot P, Vachhani P, Wang ES, Wang B, Hennessy M, Vorog A, Patel N, Yeh T, Ribera JM.   +20 more
europepmc   +2 more sources

Prognostic implications of additional genomic lesions in adult Philadelphia chromosome-positive acute lymphoblastic leukemia

Haematologica, 2019
To shed light onto the molecular basis of Philadelphia chromosome-positive acute lymphoblastic leukemia and to investigate the prognostic role of additional genomic lesions, we analyzed copy number aberrations using the Cytoscan HD Array in 116 newly ...
Anna Lucia Fedullo, Monica Messina, Loredana Elia, Alfonso Piciocchi, Valentina Gianfelici, Alessia Lauretti, Stefano Soddu, Maria Cristina Puzzolo, Clara Minotti, Felicetto Ferrara, Bruno Martino, Patrizia Chiusolo, Valeria Calafiore, Stefania Paolini, Marco Vignetti, Antonella Vitale, Anna Guarini, Robin Foà, Sabina Chiaretti   +18 more
doaj   +2 more sources

Philadelphia chromosome-positive T-cell acute lymphoblastic leukemia: a case report [PDF]

Journal of International Medical Research
Philadelphia chromosome-positive (Ph+) T-cell acute lymphoblastic leukemia (T-ALL) is a rare and aggressive type of acute leukemia. The Philadelphia chromosome is the hallmark of chronic myeloid leukemia (CML). The differentiation between Ph+ T-ALL and T-
Qianze Dong, Tarneem Darwish, Meyerson Howard, Shashirekha Shetty, Yang Wang, Yan Xiu, Molly Gallogly, Chen Zhao   +7 more
doaj   +2 more sources

Predictive value of minimal residual disease in Philadelphia-chromosome-positive acute lymphoblastic leukemia treated with imatinib in the European intergroup study of post-induction treatment of Philadelphia-chromosome-positive acute lymphoblastic leukemia, based on immunoglobulin/T-cell receptor and BCR/ABL1 methodologies

Haematologica, 2018
The prognostic value of minimal residual disease (MRD) in Philadelphia-chromosome-positive (Ph+) childhood acute lymphoblastic leukemia (ALL) treated with tyrosine kinase inhibitors is not fully established.
Giovanni Cazzaniga, Paola De Lorenzo, Julia Alten, Silja Röttgers, Jeremy Hancock, Vaskar Saha, Anders Castor, Hans O. Madsen, Virginie Gandemer, Hélène Cavé, Veronica Leoni, Rolf Köhler, Giulia M. Ferrari, Kirsten Bleckmann, Rob Pieters, Vincent van der Velden, Jan Stary, Jan Zuna, Gabriele Escherich, Udo zur Stadt, Maurizio Aricò, Valentino Conter, Martin Schrappe, Maria Grazia Valsecchi, Andrea Biondi   +24 more
doaj   +2 more sources

A case of leukemia cutis showing annular erythema during the course of Philadelphia chromosome‐positive acute B‐lymphoblastic leukemia [PDF]

Clinical Case Reports
Key Clinical Message We report a case of leukemia cutis showing annular erythema during the course of Philadelphia chromosome‐positive acute B‐lymphoblastic leukemia. The annular appearance may be developed by immunomodulatory effects of blinatumomab.
Hizuru Tomita, Yoshimasa Nobeyama, You Sakayori, Rika Matsumoto, Satomi Chujo, Hikaru Suzuki, Akihiko Asahina   +6 more
doaj   +2 more sources

Ponatinib, chemotherapy, and transplant in adults with Philadelphia chromosome–positive acute lymphoblastic leukemia

Blood Advances, 2022
Key Points Ponatinib and chemotherapy followed by alloHSCT for Ph+ ALL are effective and safe in adults aged
J. Ribera, O. García-Calduch, J. Ribera, P. Montesinos, Isabel Cano-Ferri, P. Martínez, J. Esteve, D. Esteban, María García-Fortes, N. Alonso, J. González-Campos, A. Bermúdez, A. Torrent, Eulàlia Genescà, S. Mercadal, J. Martínez-López, R. García-Sanz   +16 more
semanticscholar   +1 more source

Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs: A literature review

World Journal of Clinical Oncology, 2021
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly ― the presence of the Philadelphia chromosome.
Mariana Miranda Sampaio, Maria Luísa Cordeiro Santos, Hanna Santos Marques, Vinícius Lima de Souza Gonçalves, Glauber Rocha Lima Araújo, Luana Weber Lopes, Jonathan Santos Apolonio, Camilo Santana Silva, Luana Kauany de Sá Santos, Beatriz Rocha Cuzzuol, Quézia Estéfani Silva Guimarães, Mariana Novaes Santos, B. B. de Brito, F. A. F. da Silva, M. V. Oliveira, C. L. Souza, F. F. de Melo   +16 more
semanticscholar   +1 more source

A case of acute lymphoblastic leukemia with additional chromosomes X and 5 associated with a Philadelphia chromosome in the bone marrow

Turkish Journal of Hematology, 2010
We report herein a very rare case of acute lymphoblastic leukemia having a chromosomal constitution of 48,XY,+X,+5,t(9;22)(q34;q11) in the bone marrow.
Burak Durmaz, Asude Alpman Durmaz, Emin Karaca, Güray Saydam, Özgür Çoğulu, Ferda Özkınay   +5 more
doaj   +3 more sources