Results 11 to 20 of about 77,213 (201)

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Evaluation of Common Genetic Disorders in Myeloproliferative Neoplasms [PDF]

International Journal of Hematology-Oncology and Stem Cell Research, 2011
Introduction: The myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by excessive production of blood cells by  hematopoietic precursors. Typically, they include polycythemia vera (PV), essential thrombocythemia (ET),
Mehrdad Payandeh, Farhad Shaveisi Zadeh, Mohammad Erfan Zare, Kamran Mansouri, Reza Khodarahmi, Saeed Alimoradi, Hoshang Yousefi, Fatemeh Darabi   +7 more
doaj   +1 more source

The Philadelphia chromosome in leukemogenesis

Chinese Journal of Cancer, 2016
The truncated chromosome 22 that results from the reciprocal translocation t(9;22)(q34;q11) is known as the Philadelphia chromosome (Ph) and is a hallmark of chronic myeloid leukemia (CML).
Zhi-Jie Kang, Yu-Fei Liu, Ling-Zhi Xu, Zi-Jie Long, Dan Huang, Ya Yang, Bing Liu, Jiu-Xing Feng, Yu-Jia Pan, Jin-Song Yan, Quentin Liu   +10 more
doaj   +1 more source

Bilateral Serous Retinal Detachment in Lymphoid Blast Crisis of Chronic Myeloid Leukemia

Case Reports in Ophthalmology, 2021
We herein report a patient with Philadelphia chromosome-positive lymphoid blast crisis of chronic myeloid leukemia (CML), who presented with bilateral serous retinal detachment (SRD).
Kyohei Umemura, Kyoko Fujita, Akiko Jinno, Ayano Nakamura, Motohiro Kamei   +4 more
doaj   +1 more source

Pediatric Philadelphia-positive B lymphoblastic leukemia with CD56 expression and L2 morphology: Case report and review of the literature

Human Pathology: Case Reports, 2017
We present a unique case of pediatric B lymphoblastic leukemia with Philadelphia chromosome, CD56 expression, and predominantly L2 morphology. A review of the current literature demonstrates that this distinct combination of features is rare and may ...
Jadee Neff, MD, PhD, Dong Chen, MD, PhD
doaj   +1 more source

p185BCR/ABL has a lower sensitivity than p210BCR/ABL to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia

Haematologica, 2012
Background The t(9;22) translocation leads to the formation of the chimeric breakpoint cluster region/c-abl oncogene 1 (BCR/ABL) fusion gene on der22, the Philadelphia chromosome. The p185BCR/ABL or the p210BCR/ABL fusion proteins are encoded as a result
Afsar A. Mian, Anna Metodieva, Yousef Najajreh, Oliver G. Ottmann, Jamal Mahajna, Martin Ruthardt   +5 more
doaj   +1 more source

"Transformation of chronic myelogenous leukemia to Multiple Myeloma: A case report " [PDF]

Acta Medica Iranica, 2003
Chronic myelogenous leukemia (CML) is a stem cell disorder sometimes associated with lymphoproliferative disorders. CML may precede a lymphoproliferative disorder.
"Ghavamzadeh A, Alimoghaddam K, Mehdipour P, Sharifian R, Schwanitz G, Shamshiri AR "   +5 more
doaj   +1 more source

Efficacy and safety of low‐dose imatinib in an elderly patient with mixed phenotype acute leukemia with t(9;22)(q34;q11.2);BCR‐ABL1

Clinical Case Reports, 2021
Low‐dose imatinib with monitoring of drug concentrations in blood may successfully control Philadelphia chromosome‐positive mixed phenotype acute leukemia (Ph+MPAL), particularly in elderly patients with comorbidities.
Yusuke Okayama, Teruhito Takakuwa, Ippei Otomaru, Mirei Horiuchi, Akiko Miura, Taku Araki, Yotaro Fujitani, Ryosuke Yamamura   +7 more
doaj   +1 more source

Genetic Landscape of Myeloproliferative Neoplasms with an Emphasis on Molecular Diagnostic Laboratory Testing

Life, 2021
Chronic myeloproliferative neoplasms (MPNs) are hematopoietic stem cell neoplasms with driver events including the BCR-ABL1 translocation leading to a diagnosis of chronic myeloid leukemia (CML), or somatic mutations in JAK2, CALR, or MPL resulting in ...
Arti Easwar, Alexa J. Siddon
doaj   +1 more source

A Case of Philadelphia Chromosome Positive Myeloproliferative Neoplasm in a Pregnant Woman with Unusual Primary Myelofibrosis Features

Case Reports in Hematology, 2013
Myeloproliferative neoplasms (MPNs) are traditionally separated into BCR-ABL-positive chronic myeloid leukemia (CML), and BCR-ABL-negative MPNs including primary myelofibrosis (PMF), essential thrombocythemia (ET), and so forth.
Jason Koshy, Jack Alperin, Bagi Jana, Avi Markowitz, You-Wen Qian   +4 more
doaj   +1 more source