Results 11 to 20 of about 42,888 (218)
The Philadelphia chromosome in leukemogenesis [PDF]
Chinese Journal of Cancer, 2016 The truncated chromosome 22 that results from the reciprocal translocation t(9;22)(q34;q11) is known as the Philadelphia chromosome (Ph) and is a hallmark of chronic myeloid leukemia (CML).
Zhi-Jie Kang +10 more
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The Philadelphia chromosome in human macrophages [PDF]
Blood, 1977 Three patients with chronic myelocytic leukemia in different phases of the natural history of the disease were studied. Their bone marrow cells were cultured under conditions favoring macrophage proliferation, and parallel cytogenetic and cytochemical studies were performed.
Carmen Burgaleta +3 more
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Applying the discovery of the Philadelphia chromosome [PDF]
Journal of Clinical Investigation, 2007 The identification of the Philadelphia chromosome in cells from individuals with chronic myelogenous leukemia (CML) led to the recognition that the BCR-ABL tyrosine kinase causes CML. This in turn led to the development of imatinib mesylate, a clinically successful inhibitor of the BCR-ABL kinase.
Brian J. Druker, Daniel W. Sherbenou
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The legacy of the Philadelphia chromosome [PDF]
Journal of Clinical Investigation, 2007 The discovery of the Philadelphia chromosome as a hallmark of chronic myelogenous leukemia in 1960 by Peter Nowell provided evidence for a genetic link to cancer. As with most seminal scientific observations, the description of the Philadelphia chromosome posed many more questions than were answered.
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Frontiers in Genetics, 2022 We aim to determine the spectrum of cytogenetic abnormalities and outcomes in unbalanced offspring of asymptomatic constitutional balanced t(9;22) carriers through a systematic literature review. We also include a case of a constitutional balanced t(9;22)
Zimeng Gao +8 more
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How I diagnose and manage Philadelphia chromosome-like acute lymphoblastic leukemia
Haematologica, 2019 Advances in our understanding of mechanisms of leukemogenesis and driver mutations in acute lymphoblastic leukemia (ALL) lead to a more precise and informative sub-classification, mainly of B-cell ALL. In parallel, in recent years, novel agents have been
Avraham Frisch, Yishai Ofran
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Response to “Philadelphia chromosome?” [PDF]
American Journal of Hematology, 2006 WOS ...
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Evaluation of Common Genetic Disorders in Myeloproliferative Neoplasms [PDF]
International Journal of Hematology-Oncology and Stem Cell Research, 2011 Introduction: The myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by excessive production of blood cells by hematopoietic precursors. Typically, they include polycythemia vera (PV), essential thrombocythemia (ET),
Mehrdad Payandeh +7 more
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Bilateral Serous Retinal Detachment in Lymphoid Blast Crisis of Chronic Myeloid Leukemia
Case Reports in Ophthalmology, 2021 We herein report a patient with Philadelphia chromosome-positive lymphoid blast crisis of chronic myeloid leukemia (CML), who presented with bilateral serous retinal detachment (SRD).
Kyohei Umemura +4 more
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Haematologica, 2012 Background The t(9;22) translocation leads to the formation of the chimeric breakpoint cluster region/c-abl oncogene 1 (BCR/ABL) fusion gene on der22, the Philadelphia chromosome. The p185BCR/ABL or the p210BCR/ABL fusion proteins are encoded as a result
Afsar A. Mian +5 more
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