Results 51 to 60 of about 886,649 (291)
Case Reports in Hematology, 2013 Myeloproliferative neoplasms (MPNs) are traditionally separated into BCR-ABL-positive chronic myeloid leukemia (CML), and BCR-ABL-negative MPNs including primary myelofibrosis (PMF), essential thrombocythemia (ET), and so forth.
Jason Koshy +4 more
doaj +1 more source
Novel therapeutic targets in chronic myeloid leukaemia through a discrete time discrete Markov chain model of BCR-ABL1 interactions [PDF]
arXiv, 2020 Chronic Myeloid Leukaemia (CML) is a blood-derived proliferative disorder, which is highly associated to a translocation of chromosomes 9 and 22 or the creation of Philadelphia chromosome Ph(+) cases, inducing the synthesis of a chimeric fusion protein, namely BCR-ABL1 (Breakpoint Cluster Region-Abelson 1 chimeric protein), which is known for driving ...
arxiv
Haematologica, 2014 Allogeneic stem cell transplantation is the standard approach to Philadelphia chromosome positive acute lymphoblastic leukemia. We hypothesized that imatinib plus sequential chemotherapy will result in significant leukemia cell cytoreduction in patients ...
Meir Wetzler +12 more
doaj +1 more source
Chromosome Oscillations in Mitosis [PDF]
, 2005 Successful cell division requires a tight regulation of chromosome motion via the activity of molecular motors. Many of the key players at the origin of the forces generating the movement have been identified, but their spatial and temporal organization remains elusive.
arxiv +1 more source
Role of the Number of Microtubules in Chromosome Segregation during Cell Division [PDF]
PLoS ONE 10(10): e0141305 (2015), 2015 Faithful segregation of genetic material during cell division requires alignment of chromosomes between two spindle poles and attachment of their kinetochores to each of the poles. Failure of these complex dynamical processes leads to chromosomal instability (CIN), a characteristic feature of several diseases including cancer.
arxiv +1 more source
Journal of Clinical Oncology, 2018 Purpose Addition of imatinib to intensive chemotherapy improved survival for children and young adults with Philadelphia chromosome-positive acute lymphoblastic leukemia.
W. Slayton +24 more
semanticscholar +1 more source
Journal of Clinical Oncology, 2017 Purpose Few therapeutic options are available for patients with Philadelphia chromosome-positive (Ph+) B-precursor acute lymphoblastic leukemia (ALL) who progress after failure of tyrosine kinase inhibitor (TKI) -based therapy.
G. Martinelli +12 more
semanticscholar +1 more source
Chromosome Segmentation Analysis Using Image Processing Techniques and Autoencoders [PDF]
arXiv, 2022 Chromosome analysis and identification from metaphase images is a critical part of cytogenetics based medical diagnosis. It is mainly used for identifying constitutional, prenatal and acquired abnormalities in the diagnosis of genetic diseases and disorders.
arxiv
Journal of Clinical Oncology, 2017 Purpose Philadelphia chromosome (Ph) -like acute lymphoblastic leukemia (ALL) is a high-risk subtype of childhood ALL characterized by kinase-activating alterations that are amenable to treatment with tyrosine kinase inhibitors.
K. Roberts +36 more
semanticscholar +1 more source
Gomal Journal of Medical Sciences, 2017 Philadelphia (Ph’) chromosome is an abnormally short chromosome 22 formed as a result of translocation between chromosome 9 and 22. As a result the ABL gene from chromosome 9 joins the BCR gene on chromosome 22.
Habibullah Khan
doaj