Results 11 to 20 of about 23,968,980 (103)

Hematotoxic Effect of Respiratory Exposure to PHMG-p and Its Integrated Genetic Analysis

Toxics, 2022
Polyhexamethylene guanidine phosphate (PHMG-p), the main ingredient of humidifier disinfectants, circulates systemically through the lungs; however, its toxicological assessment has been primarily limited to pulmonary disease. Herein, we investigated the
Ju-Han Lee
exaly   +6 more sources

Assessment of the Diagnostic Value of [⁶⁸Ga]Ga-FAPI-04 and [¹⁸F]FDG PET in a PHMG-p-Induced Pulmonary Fibrosis Murine Model

Diagnostics
Background/Objectives: Pulmonary fibrosis is a progressive and fatal lung disease with limited diagnostic and therapeutic options. Fibroblast activation protein (FAP) has emerged as a promising molecular imaging target for the non-invasive assessment of ...
So Young Kim, Jun Young Park, Ye Lim Cho, Won Jun Kang   +3 more
doaj   +5 more sources

Analysis of lung cancer-related genetic changes in long-term and low-dose polyhexamethylene guanidine phosphate (PHMG-p) treated human pulmonary alveolar epithelial cells

BMC Pharmacology & Toxicology, 2022
Background Lung injury elicited by respiratory exposure to humidifier disinfectants (HDs) is known as HD-associated lung injury (HDLI). Current elucidation of the molecular mechanisms related to HDLI is mostly restricted to fibrotic and inflammatory lung
Jaeyoung Kim, Sang Hoon Jeong
exaly   +4 more sources

Effects of Exposure of PHMG-p, a Humidifier Disinfectant Component, on Eye Dryness: A Study on a Rat Model Based on 1H-NMR Metabolomics

International Journal of Molecular Sciences
Polyhexamethylene guanidine phosphate (PHMG-p), a widely used disinfectant component in household humidifiers, has been implicated in various health issues, including pulmonary toxicity. Many people use humidifiers to improve dry eye disease (DED). The current study was performed to elucidate the effect of PHMG-p on eye dryness in a rat model using ...
Gi-Wook Hwang, Hyeyoon Goo, Suhkmann Kim
exaly   +4 more sources

Guanicid and PHMG Toxicity Tests on Aquatic Organisms [PDF]

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2016
The emergence and development of new algicidal products is caused by the ever increasing popularity of garden ponds as well as the use of these products in the fisheries sector, especially for disposal of cyanobacteria and algae.
Eva Poštulková, Radovan Kopp
doaj   +2 more sources

Integrated evidence supports a causal association between PHMG-P exposure and pneumonitis [PDF]

Epidemiology and Health
Polyhexamethylene guanidine phosphate (PHMG-P) is a guanidine-based disinfectant previously used in household humidifiers in Korea. This study evaluated whether PHMG-P exposure is causally linked to pneumonitis by integrating epidemiological ...
Yong Joo Park, Hye-Jin Kim, Youngmee Lee, Haewon Kim, Ha Ryong Kim, Jaiyong Kim, Hae-Kwan Cheong, Mina Ha, Kyu Hyuck Chung   +8 more
doaj   +3 more sources

Transcriptomic Analysis of Polyhexamethyleneguanidine-Induced Lung Injury in Mice after a Long-Term Recovery

Toxics, 2021
Polyhexamethyleneguanidine phosphate (PHMG-P) is one of the causative agents of humidifier disinfectant-induced lung injury. Direct exposure of the lungs to PHMG-P causes interstitial pneumonia with fibrosis.
Jeongah Song, Kyung-Jin Jung, Jae-Woo Cho, Tamina Park, Su-Cheol Han, Daeui Park   +5 more
doaj   +2 more sources

Polyhexamethylene guanidine phosphate increases stress granule formation in human 3D lung organoids under respiratory syncytial virus infection

Ecotoxicology and Environmental Safety, 2022
Polyhexamethylene guanidine phosphate (PHMG-p), a humidifier disinfectant, is known to cause lung toxicity, including inflammation and pulmonary fibrosis.
Seri Choi, Sunkyung Choi, Yeongsoo Choi, Namjoon Cho, Seung-Yeon Kim, Chang Hyun Lee, Han-Jin Park, Won Keun Oh, Kee K. Kim, Eun-Mi Kim   +9 more
doaj   +2 more sources

Polyhexamethyleneguanidine Phosphate-Induced Cytotoxicity in Liver Cells Is Alleviated by Tauroursodeoxycholic Acid (TUDCA) via a Reduction in Endoplasmic Reticulum Stress

Cells, 2019
Polyhexamethyleneguanidine phosphate (PHMG-P) is a widely used polymeric antimicrobial agent known to induce significant pulmonary toxicity. Several studies have reported that the liver also can be a target organ of polyhexamethyleneguanidine (PHMG ...
Sou Hyun Kim, Doyoung Kwon, Seunghyun Lee, Sung Hwan Ki, Hye Gwang Jeong, Jin Tae Hong, Yun-Hee Lee, Young-Suk Jung   +7 more
doaj   +2 more sources

Polyhexamethylene Guanidine Phosphate Damages Tight Junctions and the F-Actin Architecture by Activating Calpain-1 via the P2RX7/Ca²⁺ Signaling Pathway

Cells, 2019
Polyhexamethylene guanidine phosphate (PHMG-p), a member of the polymeric guanidine family, has strong antimicrobial activity and may increase the risk of inflammation-associated pulmonary fibrosis.
Sun Woo Jin, Gi Ho Lee, Hoa Thi Pham, Jae Ho Choi, Hye Gwang Jeong   +4 more
doaj   +2 more sources