Results 21 to 30 of about 23,968,980 (103)

A Phenotypic and Genotypic Evaluation of Developmental Toxicity of Polyhexamethylene Guanidine Phosphate Using Zebrafish Embryo/Larvae

Toxics, 2020
Polyhexamethylene guanidine-phosphate (PHMG-P), a guanidine-based cationic antimicrobial polymer, is an effective antimicrobial biocide, potent even at low concentrations.
Jeongah Song, Kojo Eghan, Sangwoo Lee, Jong-Su Park, Seokjoo Yoon, Wittaya Pimtong, Woo-Keun Kim   +6 more
doaj   +2 more sources

Polyhexamethylene Guanidine Phosphate Enhanced Procoagulant Activity through Oxidative-Stress-Mediated Phosphatidylserine Exposure in Platelets

Toxics
Polyhexamethylene guanidine phosphate (PHMG-p) is a common biocidal disinfectant that is widely used in industry and household products. However, PHMG-p was misused as a humidifier disinfectant (HD) in South Korea, which had fatal health effects. Various
Ju Hee Choi, Keunyoung Kim
doaj   +2 more sources

Polyhexamethylene Guanidine Phosphate Induces Restrictive Ventilation Defect and Alters Lung Resistance and Compliance in Mice

Toxics
Polyhexamethylene guanidine phosphate (PHMG-p), a major ingredient of humidifier disinfectants, is known to induce inflammation, interstitial pneumonitis, and fibrosis in the lungs.
Yoon Hee Park, Sang-Hoon Jeong, Hong Lee, Yoon-Jeong Nam, Hyejin Lee, Yu-Seon Lee, Jin-Young Choi, Su-A Park, Mi-Jin Choi, Hayan Park, Jaeyoung Kim, Eun-Yeob Kim, Yong-Wook Baek, Jungyun Lim, Sua Kim, Je-Hyeong Kim, Ju-Han Lee   +16 more
doaj   +2 more sources

Polyhexamethylene guanidine phosphate induces epithelial-to-mesenchymal transition and cancer stem cell-like properties via Wnt/β-catenin signaling in human bronchial epithelial cells

Ecotoxicology and Environmental Safety
Inhalation exposure to polyhexamethylene guanidine phosphate (PHMG-p), a primary component of humidifier disinfectants, has been linked to interstitial lung disease and potential carcinogenic effects.
Gi Ho Lee, Seung Yeon Lee, Yong-Wook Baek, Jungyun Lim, Kyu Hyuck Chung, Hye Gwang Jeong   +5 more
doaj   +2 more sources

Comparison of repeated toxicity of polyhexamethyleneguanidine phosphate, a causative agent of humidifier disinfectant tragedy, in young and adult mice

Scientific Reports
Some drugs or chemicals exhibit different safety profiles in newborns/young children compared to adults. Polyhexamethyleneguanidine phosphate (PHMG-P) has been implicated in the humidifier disinfectant tragedy in 2011.
Jeongah Song, Jeonghee Cho, Nan Ok Shin, Mi-Jin Yang, Ji-Hoon Jung, Jeong Ho Hwang   +5 more
doaj   +2 more sources

Effects of inhalation of polyhexamethylene guanidine disinfectant aerosol on immune organs and immune cells in mice [PDF]

环境与职业医学
BackgroundThe respiratory toxicity of inhaled polyhexamethylene guanidine (PHMG) has been extensively studied since the humidifier disinfectant incident. However, the impacts of inhalation of PHMG on the immune system are not comprehensively studied yet.
Zhengli YANG, Naimin SHAO, Yu DING, Jing XU, Junli LIU, Xi LIU, Kelei QIAN, Xinyu HONG   +7 more
doaj   +2 more sources

eDNA inactivation and biofilm inhibition by the polymeric biocide polyhexamethylene guanidine hydrochloride (PHMG-Cl) [PDF]

, 2022
The choice of effective biocides used for routine hospital practice should consider the role of disinfectants in the maintenance and development of local resistome and how they might affect antibiotic resistance gene transfer within the hospital ...
Sergiy P. Rogalsky, Geert Potters, Spiers, Andrew J.; id_orcid, Rogalsky, Sergiy P., Olga S. Iungin, Moshynets, Olena V, Viktoria V. Potochilova, Ivan V. Semenyuta, Moshynets, Olena V., Larysa O. Metelytsia, Oksana P. Tarasyuk, Taras P. Baranovskyi, Ianina Pokholenko, Pokholenko, Ianina, Baranovskyi, Taras P., Andrew J. Spiers, Metelytsia, Larysa O., Rudnieva, Kateryna L., Rymar, Svitlana Y., Kysil, Nadiia P., Spiers, Andrew J., Olena V. Moshynets, Iungin, Olga S., Semenyuta, Ivan V., Potters, Geert, Tarasyuk, Oksana P., Potochilova, Viktoria V., Kateryna L. Rudnieva, Nadiia P. Kysil, Svitlana Y. Rymar   +29 more
core   +1 more source

The Activity of PHMB and Other Guanidino Containing Compounds against Acanthamoeba and Other Ocular Pathogens

Microorganisms, 2022
In recent years, a rise in the number of contact lens users in the UK and worldwide coincided with an increased incidence of microbial keratitis. The aim of this study was to investigate the antimicrobial activities of polyhexamethylene guanidine (PHMG),
Dharanga Ratnayake, Michael Ansah, Enas Al Ani, Wayne Heaselgrave   +3 more
doaj   +1 more source

The extent and severity of fibrosis after PHMG exposure.

, 2021
The extent and severity of fibrosis after PHMG exposure.
Sang Hoon Jeong (8630289), Yoon Jeong Nam (11401872), Eun-Kee Park (8674278), Jaeyoung Kim (2891579), Ju-Han Lee (9199410), Chang Hyun Lee (2195356), Ariunaa Togloom (11401875), Cherry Kim (3863416), Ja Young Kang (11401869), Jaehyung Cha (4455343), Ki Yeol Lee (11401878)   +10 more
core   +1 more source

Evaluation of the long-term effect of polyhexamethylene guanidine phosphate in a rat lung model using conventional chest computed tomography with histopathologic analysis.

PLoS ONE, 2021
There have been no studies on the effects of polyhexamethylene guanidine phosphate (PHMG) after a long period of exposure in the rodent model. We aimed to evaluate long-term lung damage after PHMG exposure using conventional chest computed tomography (CT)
Cherry Kim, Sang Hoon Jeong, Jaeyoung Kim, Ja Young Kang, Yoon Jeong Nam, Ariunaa Togloom, Jaehyung Cha, Ki Yeol Lee, Chang Hyun Lee, Eun-Kee Park, Ju-Han Lee   +10 more
doaj   +1 more source