Results 161 to 170 of about 1,235,785 (183)

Targeting Metabolomics in Primary Hypertrophic Osteoarthropathy: Uncovering Novel Insights into Disease Pathogenesis.

J Clin Endocrinol Metab
Pang Q, Qi X, Chi Y, Jiajue R, Zhang L, Cui L, Wang O, Li M, Xing X, Jiang Y, Gong Y, Xia W.   +11 more
europepmc   +1 more source

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Phosphorylation analysis of the Hippo-YAP pathway using Phos-tag

Journal of Proteomics, 2022
Phosphorylation is an essential regulatory mechanism in cells that modifies diverse substrates, such as proteins, carbohydrates, lipids, and nucleotides. Protein phosphorylation regulates function, subcellular localization, and protein-protein interactions.
Han-Sol Jeong, Jung-Soon Mo, Su-Bin Lim
exaly   +3 more sources

The PHO pathway regulates white–opaque switching and sexual mating in the human fungal pathogen Candida albicans

Current Genetics, 2020
The opportunistic fungal pathogen Candida albicans is able to switch among several morphological phenotypes in response to environmental changes. White-opaque transition is a typical phenotypic switching system involved in the regulation of pathogenesis and sexual reproduction in C. albicans.
Guanghua Huang, Qi Li
exaly   +3 more sources

Dissection of the PHO pathway in Schizosaccharomyces pombe using epistasis and the alternate repressor adenine

Current Genetics, 2014
In Saccharomyces cerevisiae, intracellular phosphate levels are maintained by the PHO pathway, activation of which is assayed by increased phosphatase activity. The PHO pathway of Schizosaccharomyces pombe upregulates phosphatase activity (encoded by pho1 (+)) during low extracellular phosphate levels, but the underlying mechanism is poorly understood.
Dennis D Wykoff
exaly   +3 more sources

Are the Multiple Signal Transduction Pathways of the Pho Regulon Due to Cross Talk or Cross Regulation?

1996
The phosphate (Pho) regulon includes a large number of coregulated genes whose expression is controlled by the environmental (extracellular) inorganic phosphate (Pi) level. Altogether 11 Pho regulon promoters for a total of 38 different genes have now been characterized in E. coli or closely related bacteria (Fig. 15.1).
Barry L Wanner
exaly   +2 more sources

Ddi1p and Rad23p play a cooperative role as negative regulators in the PHO pathway in Saccharomyces cerevisiae

Biochemical and Biophysical Research Communications, 2008
In Saccharomyces cerevisiae, the PHO pathway regulates expression of phosphate-responsive genes such as PHO5, which encodes repressible acid phosphatase (rAPase). In this pathway, Pho81p functions as an inhibitor of the cyclin-cyclin-dependent kinase (CDK) complex Pho80p-Pho85p.
Choowong, Auesukaree, Ikutaro, Fuchigami, Tomoyuki, Homma, Yoshinobu, Kaneko, Satoshi, Harashima   +4 more
openaire   +2 more sources

Hyper‐invasive mutants define a novel Pho‐regulated invasion pathway in Escherichia coli

Molecular Microbiology, 1993
SummaryWe have isolated two transposon insertion mutations of the pst–phoU operon which result in the constitutive expression of the phoA gene product, alkaline phosphatase. The two mutations also render Escherichia coli invasive towards cultured HEp‐2 cells and define a novel Pho‐regulated invasion pathway.
A P, Sinai, P M, Bavoil
openaire   +2 more sources

Rpl12p affects the transcription of the PHO pathway high‐affinity inorganic phosphate transporters and repressible phosphatases

Yeast, 2011
AbstractThe ribosomal protein Rpl12p of Saccharomyces cerevisiae is encoded by duplicated genes, RPL12A and RPL12B. The gene products possess an identical amino acid sequence. Yeast strain 6EA1, which lacks both genes, is viable but exhibits a very slow‐growth phenotype. In this study, 6EA1 cells were transformed with plasmids carrying either RPL12A or
Wen-Yo, Tu, Yu-Chen, Huang, Li-Fan, Liu, Li-Hsueh, Chang, Ming F, Tam   +4 more
openaire   +2 more sources

Pho regulon promoter-mediated transcription of the key pathway gene aroG Fbr improves the performance of an l-phenylalanine-producing Escherichia coli strain

Applied Microbiology and Biotechnology, 2010
DAHP synthase (EC 4.1.2.15) is one of the key enzymes involved in aromatic amino acid biosynthesis in Escherichia coli. An approximately twofold decrease in DAHP synthase activity level was detected in the late growth phase of the L-phenylalanine (Phe)-producing E.
Vera G, Doroshenko, Irina S, Tsyrenzhapova, Alexander A, Krylov, Evgeniya M, Kiseleva, Vladimir Yu, Ermishev, Svetlana M, Kazakova, Irina V, Biryukova, Sergey V, Mashko   +7 more
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Stochastic π-Calculus Modelling of Multisite Phosphorylation Based Signaling: The PHO Pathway in Saccharomyces Cerevisiae

2008
We propose a stochastic π-calculus modelling approach able to handle the complexity of post-translational signalling and to overcome some limitations of the ordinary differential equations based methods. The model we developed is customizable without a priori assumptions to every multisite phosphorylation regulation.
Segata, Nicola, Blanzieri, Enrico
openaire   +2 more sources