Results 51 to 60 of about 7,818 (149)

Neuroprotective Effects of RNS60 in TDP‐43 Pathology‐Associated Amyotrophic Lateral Sclerosis

Muscle &Nerve, EarlyView.
ABSTRACT Introduction TDP‐43 pathology is broadly observed in the cerebral cortex of patients with amyotrophic lateral sclerosis (ALS). RNS60, an experimental treatment for acute ischemic stroke and ALS, enhanced mitochondrial biogenesis and function in other preclinical models.
Danny R. Vesevick, Supurna Ghosh, Andreas Kalmes, P. Hande Ozdinler, Mukesh Gautam   +4 more
wiley   +1 more source

LPS-Induced Activation of the cGAS-STING Pathway is Regulated by Mitochondrial Dysfunction and Mitochondrial DNA Leakage in Endometritis

Journal of Inflammation Research, 2022
Mu-zi Li,1– 5 Xiao-yang Wen,1– 5 Xiao-qiang Liu,1– 6 Yu-qing Wang,1– 5 Lei Yan1– 5 1Center for Reproductive Medicine, Shandong University, Jinan, People’s Republic of China; 2Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong
Li M, Wen X, Liu X, Wang Y, Yan L
doaj  

The impact of phosphate scarcity on pharmaceutical protein production in S. cerevisiae: linking transcriptomic insights to phenotypic responses

Microbial Cell Factories, 2011
Background The adaptation of unicellular organisms like Saccharomyces cerevisiae to alternating nutrient availability is of great fundamental and applied interest, as understanding how eukaryotic cells respond to variations in their nutrient supply has ...
Kazemi Seresht Ali, Palmqvist Eva, Olsson Lisbeth   +2 more
doaj   +1 more source

Systemic bio‐inequity links poverty to biodiversity and induces a conservation paradox

People and Nature, EarlyView.
Abstract Biodiversity is declining globally while inequity is growing, and poverty rates are not improving. Global sustainable development and conservation initiatives aim to address biodiversity loss and poverty simultaneously. Through text analysis of global biodiversity policies, we identified a consistent narrative that countries with high ...
Conor Waldock, Van Thi Hai Nguyen, Margaret Awuor Owuor, Anna Samwel Manyanza, Ole Seehausen   +4 more
wiley   +1 more source

LurR is a regulator of the central lactate oxidation pathway in sulfate-reducing Desulfovibrio species.

PLoS ONE, 2019
The central carbon/lactate utilization pathway in the model sulfate-reducing bacterium, Desulfovibrio vulgaris Hildenborough, is encoded by the highly conserved operon DVU3025-3033.
Lara Rajeev, Eric G Luning, Grant M Zane, Thomas R Juba, Alexey E Kazakov, Pavel S Novichkov, Judy D Wall, Aindrila Mukhopadhyay   +7 more
doaj   +1 more source

Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis

PROTEOMICS, EarlyView.
ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan, Clinton J. Bradfield, Sandhini Saha, Sung Hwan Yoon, Iain D. C. Fraser, Aleksandra Nita‐Lazar   +5 more
wiley   +1 more source

Genome-Wide Ultrabithorax Binding Analysis Reveals Highly Targeted Genomic Loci at Developmental Regulators and a Potential Connection to Polycomb-Mediated Regulation.

PLoS ONE, 2016
Hox homeodomain transcription factors are key regulators of animal development. They specify the identity of segments along the anterior-posterior body axis in metazoans by controlling the expression of diverse downstream targets, including transcription
Daria Shlyueva, Antonio C A Meireles-Filho, Michaela Pagani, Alexander Stark   +3 more
doaj   +1 more source

Proteomic Profiling of Primary Hippocampal Neurons Reveals Noncanonical GFAP Expression and Metabolic Adaptations in Glia‐Free Culture

PROTEOMICS, EarlyView.
ABSTRACT Despite their widespread use as a research model, a comprehensive, quantitative proteomic profile of the cultured hippocampal neurons has remained unexplored. Here, we provide the first global proteomic characterization of primary murine hippocampal neurons cultured for 14 days under near‐physiological glucose conditions (2.5 mM).
Dominika Drulis‐Fajdasz, Kinga Gostomska‐Pampuch, Natalia Pudełko‐Malik, Mariusz Fleszar, Agnieszka Gizak, Jacek R. Wiśniewski, Dariusz Rakus   +6 more
wiley   +1 more source

Genetic Tools in the Nakaseomyces clade for Evolutionary Comparisons of Signal Transduction Pathways

Yeast, EarlyView.
ABSTRACT The genus Nakaseomyces provides four species that are closely related but have different characteristics. For example, N. glabratus (formerly known as Candida glabrata) is a common human pathogen, whereas N. bracarensis and N. nivariensis have been isolated in clinical settings but are not common human pathogens. N.
Maria Abraham, Christine L. Iosue, Dennis D. Wykoff   +2 more
wiley   +1 more source

Unveiling biodegradation mechanism of phoxim: Novel metabolic pathway, functional gene, detoxification effect, and widespread distribution of phoA

Environment International
Phoxim, an organophosphorus insecticide (OP), poses risks to non-target organisms in the environment. However, the biodegradation mechanism of phoxim was not fully understood.
Qian Li, Mingliang Zhang, Jiawen Zhu, Hongfei Liu, Gang Hu, Junqiang Hu, Kaihua Pan, Jiandong Jiang, Qing Hong   +8 more
doaj   +1 more source