Results 111 to 120 of about 1,202,348 (359)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death

Molecular Systems Biology, 2012
The altered metabolism of cancer can render cells dependent on the availability of metabolic substrates for viability. Investigating the signaling mechanisms underlying cell death in cells dependent upon glucose for survival, we demonstrate that glucose ...
Nicholas A Graham, Martik Tahmasian, Bitika Kohli, Evangelia Komisopoulou, Maggie Zhu, Igor Vivanco, Michael A Teitell, Hong Wu, Antoni Ribas, Roger S Lo, Ingo K Mellinghoff, Paul S Mischel, Thomas G Graeber   +12 more
doaj   +1 more source

Central Roles and Regulatory Mechanisms of Dual-Specificity MAPK Phosphatases in Developmental and Stress Signaling

Frontiers in Plant Science, 2018
Mitogen-Activated Protein Kinase (MAPK) cascades are conserved signaling modules that integrate multiple signaling pathways. One level of control on the activity of MAPKs is through their negative regulators, MAPK phosphatases (MKPs).
Lingyan Jiang, Lingyan Jiang, Yinhua Chen, Yinhua Chen, Lijuan Luo, Lijuan Luo, Scott C. Peck, Scott C. Peck, Scott C. Peck   +8 more
doaj   +1 more source

Brain phosphatase [PDF]

Biochemical Journal, 1936
K V, Giri, N C, Datta
openaire   +2 more sources

Intestine‐Specific Expression of Human Chimeric Intestinal Alkaline Phosphatase Attenuates Western Diet‐Induced Barrier Dysfunction and Glucose Intolerance [PDF]

, 2018
Intestinal epithelial cell derived alkaline phosphatase (IAP) dephosphorylates/detoxifies bacterial endotoxin lipopolysaccharide (LPS) in the gut lumen.
Ghosh, Shobha, Ghosh, Siddhartha S., He, Hongliang, Korzun, William, Wang, Jing, Yannie, Paul J.   +5 more
core   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Evidence for Sex-Specific Associations between Variation in Acid Phosphatase Locus 1 (ACP1) and Insulin Sensitivity in Mexican-Americans [PDF]

, 2009
Yu‐Hsiang Shu, Jaana Hartiala, Anny H. Xiang, Enrique Trigo, Jean M. Lawrence, Hooman Allayee, Thomas A. Buchanan, Nunzio Bottini, Richard M. Watanabe   +8 more
openalex   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Cerium Oxide Nanoparticles Role as Antioxidant

Medical Journal of Babylon
Cerium oxide nanoparticles (NPs), also known as ceria NPs, are particles of cerium oxide with sizes in the nanometer range. Cerium oxide (CeO2) is a compound composed of cerium and oxygen, and when it is reduced to NPs, it exhibits unique properties and ...
Sura A. Abdulsattar
doaj   +1 more source

Four tillage method assessments on soil organic carbon, total nitrogen, biological activities, and maize grain yield in Southern China

Food and Energy Security, 2019
Creating a soil habitat is the first step to manage soil health for long‐term soil quality and output. This means using soil management methods that lessen the soil uproar.
Evans Asenso, Lian Hu, Fuseini Issaka, Kai Tian, Lina Zhang, Luyong Zhang, Jiefeng Zeng, Yan‐Fei Zhu, Jiuhao Li   +8 more
doaj   +1 more source