Results 111 to 120 of about 1,206,748 (358)

Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death

Molecular Systems Biology, 2012
The altered metabolism of cancer can render cells dependent on the availability of metabolic substrates for viability. Investigating the signaling mechanisms underlying cell death in cells dependent upon glucose for survival, we demonstrate that glucose ...
Nicholas A Graham, Martik Tahmasian, Bitika Kohli, Evangelia Komisopoulou, Maggie Zhu, Igor Vivanco, Michael A Teitell, Hong Wu, Antoni Ribas, Roger S Lo, Ingo K Mellinghoff, Paul S Mischel, Thomas G Graeber   +12 more
doaj   +1 more source

Central Roles and Regulatory Mechanisms of Dual-Specificity MAPK Phosphatases in Developmental and Stress Signaling

Frontiers in Plant Science, 2018
Mitogen-Activated Protein Kinase (MAPK) cascades are conserved signaling modules that integrate multiple signaling pathways. One level of control on the activity of MAPKs is through their negative regulators, MAPK phosphatases (MKPs).
Lingyan Jiang, Lingyan Jiang, Yinhua Chen, Yinhua Chen, Lijuan Luo, Lijuan Luo, Scott C. Peck, Scott C. Peck, Scott C. Peck   +8 more
doaj   +1 more source

Brain phosphatase [PDF]

Biochemical Journal, 1936
K V, Giri, N C, Datta
openaire   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Conserved sequence motifs among bacterial, eukaryotic, and archaeal phosphatases that define a new phosphohydrolase superfamily [PDF]

, 1998
María Cristina Thaller, Serena Schippa, Gian María Rossolini   +2 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Cerium Oxide Nanoparticles Role as Antioxidant

Medical Journal of Babylon
Cerium oxide nanoparticles (NPs), also known as ceria NPs, are particles of cerium oxide with sizes in the nanometer range. Cerium oxide (CeO2) is a compound composed of cerium and oxygen, and when it is reduced to NPs, it exhibits unique properties and ...
Sura A. Abdulsattar
doaj   +1 more source

Four tillage method assessments on soil organic carbon, total nitrogen, biological activities, and maize grain yield in Southern China

Food and Energy Security, 2019
Creating a soil habitat is the first step to manage soil health for long‐term soil quality and output. This means using soil management methods that lessen the soil uproar.
Evans Asenso, Lian Hu, Fuseini Issaka, Kai Tian, Lina Zhang, Luyong Zhang, Jiefeng Zeng, Yan‐Fei Zhu, Jiuhao Li   +8 more
doaj   +1 more source

Alkaline phosphatase from the Antarctic strain TAB5 [PDF]

, 2000
M. Rina, Charalambos Pozidis, Konstantinos Mavromatis, Maria Tzanodaskalaki, Michael Kokkinidis, Vassilis Bouriotis   +5 more
openalex   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source