Results 131 to 140 of about 1,206,748 (358)

Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) Protein Is Involved in Centrosome Separation through the Regulation of NIMA (Never In Mitosis Gene A)-related Kinase 2 (NEK2) Protein Activity [PDF]

, 2013
Ae Lee Jeong, Sunyi Lee, Jeong Su Park, Sora Han, Chang‐Young Jang, Jong‐Seok Lim, Myung Sok Lee, Young Yang   +7 more
openalex   +1 more source

Isoquinoline Alkaloids as Protein Tyrosine Phosphatase Inhibitors from a Deep-Sea-Derived Fungus Aspergillus puniceus [PDF]

, 2022
Chengmei Liu, Fei-Hua Yao, Xinhua Lu, Xuexia Zhang, Lianxiang Luo, Liang Xiao, Shu‐Hua Qi   +6 more
openalex   +1 more source

Elucidating Signal Transduction Modulatory Drug Target Network of Colon Cancer: A Network Biology Approach [PDF]

, 2010
Latest evaluation and validation of cancer drugs and their targets has demonstrated the lack and inadequate development of new and better drugs, based on available protocols.
Biplab Bhattacharjee, Deepak Ranjan Sethi, Ibnul Hassan, Jayadeepa R.M, Sanjay Kundu, Sushil Kumar Middha   +5 more
core   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Phosphatase to kinase switch of a critical enzyme contributes to timing of cell differentiation

mBio
Cell differentiation is an essential biological process that is subject to strict temporal regulation. Caulobacter crescentus undergoes obligate differentiation from a swarmer cell to a stationary, replication-competent stalked cell with each cell cycle.
Trisha N. Chong, Mayura Panjalingam, Saumya Saurabh, Lucy Shapiro   +3 more
doaj   +1 more source

Three New Pigment Protein Tyrosine Phosphatases Inhibitors from the Insect Parasite Fungus Cordyceps gracilioides: Terreusinone A, Pinophilin C and Cryptosporioptide A [PDF]

, 2015
Pei-Yao Wei, Linxia Liu, Ting Liu, Chuan Chen, Du‐Qiang Luo, Bao‐Zhong Shi   +5 more
openalex   +1 more source

Cover crop residues effect on soil structural stability and phosphatase activity [PDF]

, 2021
Gheorghe Stegarescu, Endla Reintam, Tõnu Tõnutare   +2 more
openalex   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Nanozymes with phosphatase-like activity

Frontiers in Nanotechnology
Nanozymes with phosphatase-like activity are a class of artificial nano-catalysts that mimic the catalytic functions of natural phosphatases. They have attracted widespread attention in the biomedical field in recent years owing to their superior ...
Yu Cao, Yu Cao, Yu Cao, Shudong Zhu, Shudong Zhu, Shudong Zhu   +5 more
doaj   +1 more source

Diphosphonucleotide phosphatase/phosphodiesterase from yellow lupin (Lupinus luteus L.) belongs to a novel group of specific metallophosphatases [PDF]

, 2002
Mariusz Olczak, Teresa Olczak
openalex   +1 more source