Results 21 to 30 of about 1,424,154 (388)
Frontiers in Cell and Developmental Biology, 2023 Rare genetic disorders represent some of the most severe and life-limiting conditions that constitute a considerable burden on global healthcare systems and societies. Most individuals affected by rare disorders remain undiagnosed, highlighting the unmet
Ekaterina Lyulcheva-Bennett +2 more
doaj +1 more source
Impact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repair [PDF]
, 2012 Microcephaly with early-onset, intractable seizures and developmental delay (MCSZ) is a hereditary disease caused by mutations in polynucleotide kinase/phosphatase (PNKP), a DNA strand break repair protein with DNA 5'-kinase and DNA 3'-phosphatase ...
Alexandra K. Walker +41 more
core +1 more source
Regulation of NLRP3 Inflammasome by Phosphorylation
Frontiers in Immunology, 2018 The cytosolic pattern recognition receptor (PRR) NOD-like receptor family, pyrin domain containing 3 (NLRP3) senses a wide range of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs).
Nan Song, Nan Song, Tao Li, Tao Li
doaj +1 more source
MKP1 mediates resistance to therapy in HER2-positive breast tumors. [PDF]
, 2015 Mitogen-activated protein kinase phosphatase 1 (MKP1 or DUSP1) is an antiapoptotic phosphatase that is overexpressed in many cancers, including breast cancer.
Candas, Demet, Li, Jian Jian
core +2 more sources
Frontiers in Genetics, 2014 Protein phosphorylation homoeostasis is tightly controlled and pathological conditions are caused by subtle alterations of the cell phosphorylation profile. Altered levels of kinase activities have already been associated to specific diseases.
Francesca eSacco +9 more
doaj +1 more source
PTEN Protein Phosphatase Activity Is Not Required for Tumour Suppression in the Mouse Prostate
Biomolecules, 2022 Loss PTEN function is one of the most common events driving aggressive prostate cancers and biochemically, PTEN is a lipid phosphatase which opposes the activation of the oncogenic PI3K-AKT signalling network.
Helen M. Wise +7 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2018 Autophagy protease ATG4B is a key regulator of the LC3/GABARAP conjugation system required for autophagosome formation, maturation and closure. Members of the ATG4 and the LC3/GABARAP family have been implicated in various diseases including cancer, and ...
Niccolo Pengo +10 more
doaj +1 more source
Using Biochar and Vermiwash to Improve Biological Activities of Soil
Agriculture, 2022 The recycling of key nutrients and bioenergy from waste materials is a goal of sustainable agriculture. The co-application of biochar and a vermicompost solution (vermiwash) could enhance the positive effects of both materials on soil biomass and ...
Michelangelo Becagli +2 more
doaj +1 more source
Anchored phosphatases modulate glucose homeostasis. [PDF]
, 2012 Endocrine release of insulin principally controls glucose homeostasis. Nutrient-induced exocytosis of insulin granules from pancreatic β-cells involves ion channels and mobilization of Ca(2+) and cyclic AMP (cAMP) signalling pathways.
Cirulli, Vincenzo +12 more
core +1 more source
Revista Brasileira de Ciência do Solo, 2007 A utilização agrícola de biossólidos tem sido muito incentivada, mas, como esses resíduos apresentam composição química variada, o valor agronômico e os efeitos sobre características indicadoras de qualidade do solo precisam ser avaliados caso a caso, a ...
Isabel Cristina de Barros Trannin +2 more
doaj +1 more source