Results 21 to 30 of about 1,127,331 (318)

Combining affinity proteomics and network context to identify new phosphatase substrates and adapters in growth pathways.

open access: yesFrontiers in Genetics, 2014
Protein phosphorylation homoeostasis is tightly controlled and pathological conditions are caused by subtle alterations of the cell phosphorylation profile. Altered levels of kinase activities have already been associated to specific diseases.
Francesca eSacco   +9 more
doaj   +1 more source

PTEN Protein Phosphatase Activity Is Not Required for Tumour Suppression in the Mouse Prostate

open access: yesBiomolecules, 2022
Loss PTEN function is one of the most common events driving aggressive prostate cancers and biochemically, PTEN is a lipid phosphatase which opposes the activation of the oncogenic PI3K-AKT signalling network.
Helen M. Wise   +7 more
doaj   +1 more source

MKP1 mediates resistance to therapy in HER2-positive breast tumors. [PDF]

open access: yes, 2015
Mitogen-activated protein kinase phosphatase 1 (MKP1 or DUSP1) is an antiapoptotic phosphatase that is overexpressed in many cancers, including breast cancer.
Candas, Demet, Li, Jian Jian
core   +2 more sources

Identification of Kinases and Phosphatases That Regulate ATG4B Activity by siRNA and Small Molecule Screening in Cells

open access: yesFrontiers in Cell and Developmental Biology, 2018
Autophagy protease ATG4B is a key regulator of the LC3/GABARAP conjugation system required for autophagosome formation, maturation and closure. Members of the ATG4 and the LC3/GABARAP family have been implicated in various diseases including cancer, and ...
Niccolo Pengo   +10 more
doaj   +1 more source

Using Biochar and Vermiwash to Improve Biological Activities of Soil

open access: yesAgriculture, 2022
The recycling of key nutrients and bioenergy from waste materials is a goal of sustainable agriculture. The co-application of biochar and a vermicompost solution (vermiwash) could enhance the positive effects of both materials on soil biomass and ...
Michelangelo Becagli   +2 more
doaj   +1 more source

Myotubularin MTM1 Involved in Centronuclear Myopathy and its Roles in Human and Yeast Cells [PDF]

open access: yesJournal of Molecular and Genetic Medicine, OMICS International, 2015, 08 (02), 2018
Mutations in the MTM1 gene, encoding the phosphoinositide phosphatase myotubularin, are responsible for the X-linked centronuclear myopathy (XLCNM) or X-linked myotubular myopathy (XLMTM). The MTM1 gene was first identified in 1996 and its function as a PtdIns3P and PtdIns(,5)P2 phosphatase was discovered in 2000.
arxiv   +1 more source

Some Biochemical, Haematological and Histological Responses to a Long Term Consumption of Telfairia occidentalis-Supplemented Diet in Rats [PDF]

open access: yes, 2009
Some biochemical, haematological and histological responses were studied in rats undergoing a long term feeding with a Telfairia occidentalis-supplemented diet.
Iweala, E. E. J., Obidoa, O.
core   +1 more source

Características biológicas do solo indicadoras de qualidade após dois anos de aplicação de biossólido industrial e cultivo de milho Biological characteristics indicators of soil quality after two years of application of an industrial biosolid and corn cultivation

open access: yesRevista Brasileira de Ciência do Solo, 2007
A utilização agrícola de biossólidos tem sido muito incentivada, mas, como esses resíduos apresentam composição química variada, o valor agronômico e os efeitos sobre características indicadoras de qualidade do solo precisam ser avaliados caso a caso, a ...
Isabel Cristina de Barros Trannin   +2 more
doaj   +1 more source

A Comprehensive Review of Receptor-Type Tyrosine-Protein Phosphatase Gamma (PTPRG) Role in Health and Non-Neoplastic Disease

open access: yesBiomolecules, 2022
Protein tyrosine phosphatase receptor gamma (PTPRG) is known to interact with and regulate several tyrosine kinases, exerting a tumor suppressor role in several type of cancers.
Christian Boni   +2 more
doaj   +1 more source

Anchored phosphatases modulate glucose homeostasis. [PDF]

open access: yes, 2012
Endocrine release of insulin principally controls glucose homeostasis. Nutrient-induced exocytosis of insulin granules from pancreatic β-cells involves ion channels and mobilization of Ca(2+) and cyclic AMP (cAMP) signalling pathways.
Cirulli, Vincenzo   +12 more
core   +1 more source

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