Results 21 to 30 of about 1,202,348 (359)

Protein kinase A (PKA) phosphorylation of Shp2 inhibits its phosphatase activity and modulates ligand specificity. [PDF]

open access: yes, 2015
Pathological cardiac hypertrophy (an increase in cardiac mass resulting from stress-induced cardiac myocyte growth) is a major factor underlying heart failure.
Burmeister, BT   +5 more
core   +1 more source

A Plasmodium falciparum protein tyrosine phosphatase inhibitor identified from the ChEMBL‐NTD database blocks parasite growth

open access: yesFEBS Open Bio, 2021
Post‐translational modifications, especially reversible phosphorylation, are among the most common mechanisms that regulate protein function and biological processes in Plasmodium species. Of the Plasmodium phosphatases, phosphatase of regenerating liver
Rajan Pandey   +4 more
doaj   +1 more source

The Role of DmCatD, a Cathepsin D-Like Peptidase, and Acid Phosphatase in the Process of Follicular Atresia in Dipetalogaster maxima (Hemiptera: Reduviidae), a Vector of Chagas' Disease [PDF]

open access: yes, 2015
In this work, we have investigated the involvement of DmCatD, a cathepsin D-like peptidase, and acid phosphatase in the process of follicular atresia of Dipetalogaster maxima, a hematophagous insect vector of Chagas' disease. For the studies, fat bodies,
Canavoso, Lilian Etelvina   +3 more
core   +3 more sources

A retrospective analysis of phosphatase catalytic subunit gene variants in patients with rare disorders identifies novel candidate neurodevelopmental disease genes

open access: yesFrontiers in Cell and Developmental Biology, 2023
Rare genetic disorders represent some of the most severe and life-limiting conditions that constitute a considerable burden on global healthcare systems and societies. Most individuals affected by rare disorders remain undiagnosed, highlighting the unmet
Ekaterina Lyulcheva-Bennett   +2 more
doaj   +1 more source

Temperature dependent effect of difenoconazole on enzymatic activity from the soil [PDF]

open access: yesJournal of the Serbian Chemical Society, 2015
The purpose of this study was to quantify the effect of difenoconazole (DFC) on the activity of a few enzymes commonly found on soil: dehydrogenase, urease, phosphatase and protease.
Filimon Marioara Nicoleta   +4 more
doaj   +1 more source

Structure–Activity Studies on Bis-Sulfonamide SHIP1 Activators

open access: yesMolecules, 2023
The SH2-containing inositol polyphosphate 5-phosphatase 1 (SHIP1) enzyme opposes the activity of PI3K and therefore is of interest in the treatment of inflammatory disorders.
Shea T. Meyer   +6 more
doaj   +1 more source

Anchored phosphatases modulate glucose homeostasis. [PDF]

open access: yes, 2012
Endocrine release of insulin principally controls glucose homeostasis. Nutrient-induced exocytosis of insulin granules from pancreatic β-cells involves ion channels and mobilization of Ca(2+) and cyclic AMP (cAMP) signalling pathways.
Cirulli, Vincenzo   +12 more
core   +1 more source

Genetic Variants in Protein Tyrosine Phosphatase Non-Receptor Type 23 Are Responsible for Mesiodens Formation

open access: yesBiology, 2023
A mesiodens is a supernumerary tooth located in the midline of the premaxilla. To investigate the genetic cause of mesiodens, clinical and radiographic examination were performed on 23 family members of a two-generation Hmong family.
Ploy Adisornkanj   +11 more
doaj   +1 more source

A general biochemical kinetics data fitting algorithm for quasi-steady-state detection

open access: yesLietuvos Matematikos Rinkinys, 2016
We develop a general algorithm for fitting the biochemical kinetics data. The developed algorithm searches and analyzes numerous minima. This approach allows us to analyze biochemical data without a priori quasi-steady-state assumptions.
Justinas V. Daugmaudis   +3 more
doaj   +1 more source

Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosis [PDF]

open access: yes, 2010
Sds22 defines protein phosphatase 1 location and function at kinetochores and subsequent activity of aurora B in ...
DeLuca, Jennifer G.   +5 more
core   +4 more sources

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