Results 21 to 30 of about 1,206,748 (358)

??????????????? ????????? ????????? ?????? ??? ???????????? [PDF]

open access: yes, 2015
??????????????? ????????? ???????????? ???????????? ?????? ?????????????????? ??????????????? ?????? ???????????? ??????. ??? ??????????????? ??????????????? ??? ?????? ????????? ???????????? ????????? ??????????????? ????????? ???????????????. ?????? ???
Hwang, Jae-Sam   +8 more
core   +1 more source

A Plasmodium falciparum protein tyrosine phosphatase inhibitor identified from the ChEMBL‐NTD database blocks parasite growth

open access: yesFEBS Open Bio, 2021
Post‐translational modifications, especially reversible phosphorylation, are among the most common mechanisms that regulate protein function and biological processes in Plasmodium species. Of the Plasmodium phosphatases, phosphatase of regenerating liver
Rajan Pandey   +4 more
doaj   +1 more source

Some Biochemical, Haematological and Histological Responses to a Long Term Consumption of Telfairia occidentalis-Supplemented Diet in Rats [PDF]

open access: yes, 2009
Some biochemical, haematological and histological responses were studied in rats undergoing a long term feeding with a Telfairia occidentalis-supplemented diet.
Iweala, E. E. J., Obidoa, O.
core   +1 more source

A retrospective analysis of phosphatase catalytic subunit gene variants in patients with rare disorders identifies novel candidate neurodevelopmental disease genes

open access: yesFrontiers in Cell and Developmental Biology, 2023
Rare genetic disorders represent some of the most severe and life-limiting conditions that constitute a considerable burden on global healthcare systems and societies. Most individuals affected by rare disorders remain undiagnosed, highlighting the unmet
Ekaterina Lyulcheva-Bennett   +2 more
doaj   +1 more source

Protein kinase A (PKA) phosphorylation of Shp2 inhibits its phosphatase activity and modulates ligand specificity. [PDF]

open access: yes, 2015
Pathological cardiac hypertrophy (an increase in cardiac mass resulting from stress-induced cardiac myocyte growth) is a major factor underlying heart failure.
Burmeister, BT   +5 more
core   +1 more source

Temperature dependent effect of difenoconazole on enzymatic activity from the soil [PDF]

open access: yesJournal of the Serbian Chemical Society, 2015
The purpose of this study was to quantify the effect of difenoconazole (DFC) on the activity of a few enzymes commonly found on soil: dehydrogenase, urease, phosphatase and protease.
Filimon Marioara Nicoleta   +4 more
doaj   +1 more source

Structure–Activity Studies on Bis-Sulfonamide SHIP1 Activators

open access: yesMolecules, 2023
The SH2-containing inositol polyphosphate 5-phosphatase 1 (SHIP1) enzyme opposes the activity of PI3K and therefore is of interest in the treatment of inflammatory disorders.
Shea T. Meyer   +6 more
doaj   +1 more source

DNA 3 '-Phosphatase Activity Is Critical for Rapid Global Rates of Single-Strand Break Repair following Oxidative Stress [PDF]

open access: yes, 2009
Oxidative stress is a major source of chromosome single-strand breaks (SSBs), and the repair of these lesions is retarded in neurodegenerative disease. The rate of the repair of oxidative SSBs is accelerated by XRCC1, a scaffold protein that is essential
Breslin, Claire, Caldecott, Keith W
core   +2 more sources

PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPAR?? at Ser273 [PDF]

open access: yes, 2020
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a master regulator of adipose tissue biology. In obesity, phosphorylation of PPAR gamma at Ser273 (pSer273) by cyclin-dependent kinase 5 (CDK5)/extracellular signal-regulated kinase (ERK ...
Choi, Jang Hyun   +11 more
core   +1 more source

Genetic Variants in Protein Tyrosine Phosphatase Non-Receptor Type 23 Are Responsible for Mesiodens Formation

open access: yesBiology, 2023
A mesiodens is a supernumerary tooth located in the midline of the premaxilla. To investigate the genetic cause of mesiodens, clinical and radiographic examination were performed on 23 family members of a two-generation Hmong family.
Ploy Adisornkanj   +11 more
doaj   +1 more source

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