Results 21 to 30 of about 1,127,547 (305)

A Plasmodium falciparum protein tyrosine phosphatase inhibitor identified from the ChEMBL‐NTD database blocks parasite growth

FEBS Open Bio, 2021
Post‐translational modifications, especially reversible phosphorylation, are among the most common mechanisms that regulate protein function and biological processes in Plasmodium species. Of the Plasmodium phosphatases, phosphatase of regenerating liver
Rajan Pandey, Priya Gupta, Asif Mohmmed, Pawan Malhotra, Dinesh Gupta   +4 more
doaj   +1 more source

A retrospective analysis of phosphatase catalytic subunit gene variants in patients with rare disorders identifies novel candidate neurodevelopmental disease genes

Frontiers in Cell and Developmental Biology, 2023
Rare genetic disorders represent some of the most severe and life-limiting conditions that constitute a considerable burden on global healthcare systems and societies. Most individuals affected by rare disorders remain undiagnosed, highlighting the unmet
Ekaterina Lyulcheva-Bennett, Genomics England Research Consortium, Daimark Bennett   +2 more
doaj   +1 more source

Enzymatic activity toward poly(L-lactic acid) implants [PDF]

, 1990
Tissue reactions toward biodegradable poly(L-lactic acid) implants were monitored by studying the activity pattern of seven enzymes as a function of time: alkaline phosphatase, acid phosphatase, -naphthyl acetyl esterase, -glucuronidase, ATP-ase, NADH ...
Feijen, J., Hardonk, M.J., Molenaar, I., Nieuwenhuis, P., Schakenraad, J.M.   +4 more
core   +4 more sources

Temperature dependent effect of difenoconazole on enzymatic activity from the soil [PDF]

Journal of the Serbian Chemical Society, 2015
The purpose of this study was to quantify the effect of difenoconazole (DFC) on the activity of a few enzymes commonly found on soil: dehydrogenase, urease, phosphatase and protease.
Filimon Marioara Nicoleta, Voia Sorin Octavian, Vladoiu Diana Larisa, Isvoran Adriana, Ostafe Vasile   +4 more
doaj   +1 more source

Structure–Activity Studies on Bis-Sulfonamide SHIP1 Activators

Molecules, 2023
The SH2-containing inositol polyphosphate 5-phosphatase 1 (SHIP1) enzyme opposes the activity of PI3K and therefore is of interest in the treatment of inflammatory disorders.
Shea T. Meyer, Sandra Fernandes, Robert E. Anderson, Angela Pacherille, Bonnie Toms, William G. Kerr, John D. Chisholm   +6 more
doaj   +1 more source

Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons [PDF]

, 2006
We examined the effects of the chemokine fractalkine (CX3CL1) on EPSCs evoked by electrical stimulation of Schaffer collaterals in patch-clamped CA1 pyramidal neurons from rat hippocampal slices.
BERTOLLINI, Cristina, CHARO IF, DI ANGELANTONIO, SILVIA, EUSEBI, Fabrizio, GROSS C, LIMATOLA, Cristina, MAGGI, Laura, RAGOZZINO, Davide Antonio, TRETTEL, Flavia   +8 more
core   +1 more source

Genetic Variants in Protein Tyrosine Phosphatase Non-Receptor Type 23 Are Responsible for Mesiodens Formation

Biology, 2023
A mesiodens is a supernumerary tooth located in the midline of the premaxilla. To investigate the genetic cause of mesiodens, clinical and radiographic examination were performed on 23 family members of a two-generation Hmong family.
Ploy Adisornkanj, Rajit Chanprasit, Steven Eliason, Juan M. Fons, Worrachet Intachai, Sissades Tongsima, Bjorn Olsen, Stefan T. Arold, Chumpol Ngamphiw, Brad A. Amendt, Abigail S. Tucker, Piranit Kantaputra   +11 more
doaj   +1 more source

A Sarcoplasmic Reticulum Localized Protein Phosphatase Regulates Phospholamban Phosphorylation and Promotes Ischemia Reperfusion Injury in the Heart. [PDF]

, 2017
Phospholamban (PLN) is a key regulator of sarcolemma calcium uptake in cardiomyocyte, its inhibitory activity to SERCA is regulated by phosphorylation. PLN hypophosphorylation is a common molecular feature in failing heart.
Akaike, Toru, Du, Na, Lu, Gang, Minamisawa, Susumu, Ruan, Hongmei, Wang, Yibin   +5 more
core   +1 more source

PTEN: A master regulator of neuronal structure, function, and plasticity. [PDF]

, 2014
PTEN (phosphatase and tensin homolog on chromosome ten) is a dual protein/lipid phosphatase that dephosphorylates PIP3, thereby inhibiting the AKT/mTOR pathway. This inhibition ultimately decreases protein translation, cell proliferation and cell growth.
Garcia-Junco-Clemente, Pablo, Golshani, Peyman   +1 more
core   +1 more source

Split histidine kinases enable ultrasensitivity and bistability in two-component signaling networks [PDF]

, 2012
Bacteria sense and respond to their environment through signaling cascades generally referred to as two-component signaling networks. These networks comprise histidine kinases and their cognate response regulators.
Amin, Munia, Porter, Steven L., Soyer, Orkun S.   +2 more
core   +8 more sources