Results 21 to 30 of about 854,382 (304)

Modulation of TCR Signaling by Tyrosine Phosphatases: From Autoimmunity to Immunotherapy

Frontiers in Cell and Developmental Biology, 2020
Early TCR signaling is dependent on rapid phosphorylation and dephosphorylation of multiple signaling and adaptor proteins, leading to T cell activation.
Patricia Castro-Sanchez, Alexandra R. Teagle, Sonja Prade, Rose Zamoyska   +3 more
doaj   +1 more source

ULK1 phosphorylation of striatin activates protein phosphatase 2A and autophagy

Cell Reports, 2021
Summary: The evolutionarily conserved ULK1 kinase complex acts as gatekeeper of canonical autophagy and regulates induction of autophagosome biogenesis.
Zehan Hu, Devanarayanan Siva Sankar, Bich Vu, Alexandre Leytens, Christine Vionnet, Wenxian Wu, Michael Stumpe, Esther Martínez-Martínez, Björn Stork, Jörn Dengjel   +9 more
doaj   +1 more source

Acid phosphatases [PDF]

Molecular Pathology, 2002
Acid phosphatases (APs) are a family of enzymes that are widespread in nature, and can be found in many animal and plant species. Mystery surrounds the precise functional role of these molecular facilitators, despite much research. Yet, paradoxically, human APs have had considerable impact as tools of clinical investigation and intervention.
Bull, H., Murray, Paul G., Thomas, David G., Fraser, A. M., Nelson, Paul N.   +4 more
openaire   +3 more sources

A new histochemical method using human placenta alkaline phosphatase for demonstrating concanavalin A binding sites on cell surfaces [PDF]

, 1975
Human placenta alkaline phosphatase (HP-ALP), a glycoprotein, was stained histochemically for the purpose of examining the concanavalin A (Con A) binding sites on the cell surface. HP-ALP was bound to the cell surface by Con A.
Oda, Takuzo, Yoshioka, Tamotsu, Kanzaki, Yoshito   +2 more
core   +1 more source

Central Roles and Regulatory Mechanisms of Dual-Specificity MAPK Phosphatases in Developmental and Stress Signaling

Frontiers in Plant Science, 2018
Mitogen-Activated Protein Kinase (MAPK) cascades are conserved signaling modules that integrate multiple signaling pathways. One level of control on the activity of MAPKs is through their negative regulators, MAPK phosphatases (MKPs).
Lingyan Jiang, Lingyan Jiang, Yinhua Chen, Yinhua Chen, Lijuan Luo, Lijuan Luo, Scott C. Peck, Scott C. Peck, Scott C. Peck   +8 more
doaj   +1 more source

Phosphate-solubilizing function of Pediococcus pentosaceus PSM16 and its underlying mechanism

Microbiology Spectrum
Phosphorus is a crucial nutrient for plant growth, but only a limited quantity is typically accessible in the soil for plants to absorb directly. Phosphate-solubilizing bacteria (PSB) can convert inorganic phosphorus compounds into forms that are more ...
Hong Yaling, Chen Shasha, Li Mengyao, Li Wenhui, Gao Yan, Luo Mengjiao, Zhou Qian, Zhou Siyuan, Zhou Diao, Li Xinhui, Zhang Lei, Zhou Qiong, Yang Ziqiang, Xia Yandong, Zhang Gaihua, Jia Yin   +15 more
doaj   +1 more source

Metagenomic Evidence of Microbial Community Responsiveness to Phosphorus and Salinity Gradients in Seagrass Sediments

Frontiers in Microbiology, 2018
Sediment microorganisms can have profound influence on productivity and functioning of marine ecosystems through their critical roles in regulating biogeochemical processes.
Matthew W. Fraser, Matthew W. Fraser, Deirdre B. Gleeson, Pauline F. Grierson, Bonnie Laverock, Bonnie Laverock, Bonnie Laverock, Gary A. Kendrick, Gary A. Kendrick   +8 more
doaj   +1 more source

Threonine 348 regulates the subcellular localization of PTEN. [PDF]

FEBS Open Bio
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Kato T, Tanaka S, Ohashi M.
europepmc   +2 more sources

Protein Phosphatase 1 Regulates Human Cytomegalovirus Protein Translation by Restraining AMPK Signaling

Frontiers in Microbiology, 2021
Human cytomegalovirus (HCMV) carries the human protein phosphatase 1 (PP1) and other human proteins important for protein translation in its tegument layer for a rapid supply upon infection.
Carmen Stecher, Sanja Marinkov, Lucia Mayr-Harting, Ana Katic, Marie-Theres Kastner, Franz J. J. Rieder-Rommer, Xionghao Lin, Sergei Nekhai, Christoph Steininger   +8 more
doaj   +1 more source

Functional cdc25C dual-specificity phosphatase is required for S-phase entry in human cells [PDF]

, 2003
In view of the common regulatory mechanism that induces transcription of tie mitotic phosphatase cdc25C and cyclin A at the beginning of S-phase, we investigated whether cdc25C was required for S-phase transit.
Patric Turowski, Franckhauser, Céline, Ned J. C. Lamb, Lamb, Ned,, Celine Franckhauser, Fernandez, A, Lamb, NJC, Turowski, P, Fernandez, Anne, Turowski, Patric, Morris, May, Franckhauser, C, Vaglio, P, Vaglio, Philippe, Morris, MC, Lamb, Ned, J., Anne Fernandez, May C. Morris, Anne Fern, Philippe Vaglio   +19 more
core   +1 more source