Structure–Activity Studies on Bis-Sulfonamide SHIP1 Activators
Molecules, 2023 The SH2-containing inositol polyphosphate 5-phosphatase 1 (SHIP1) enzyme opposes the activity of PI3K and therefore is of interest in the treatment of inflammatory disorders.
Shea T. Meyer +6 more
doaj +1 more source
Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons [PDF]
, 2006 We examined the effects of the chemokine fractalkine (CX3CL1) on EPSCs evoked by electrical stimulation of Schaffer collaterals in patch-clamped CA1 pyramidal neurons from rat hippocampal slices.
BERTOLLINI, Cristina +8 more
core +1 more source
Plants, 2023 Protein phosphatase 2A (PP2A) is a heterotrimeric conserved serine/threonine phosphatase complex that includes catalytic, scaffolding, and regulatory subunits.
Ahmed Elshobaky +3 more
doaj +1 more source
Enzymatic activity toward poly(L-lactic acid) implants [PDF]
, 1990 Tissue reactions toward biodegradable poly(L-lactic acid) implants were monitored by studying the activity pattern of seven enzymes as a function of time: alkaline phosphatase, acid phosphatase, -naphthyl acetyl esterase, -glucuronidase, ATP-ase, NADH ...
Feijen, J. +4 more
core +4 more sources
Diversity in Sensing and Signaling of Bacterial Sensor Histidine Kinases
Biomolecules, 2021 Two-component signal transduction systems (TCSs) are widely conserved in bacteria to respond to and adapt to the changing environment. Since TCSs are also involved in controlling the expression of virulence, biofilm formation, quorum sensing, and ...
Eiji Ishii, Yoko Eguchi
doaj +1 more source
Protein kinase A (PKA) phosphorylation of Shp2 inhibits its phosphatase activity and modulates ligand specificity. [PDF]
, 2015 Pathological cardiac hypertrophy (an increase in cardiac mass resulting from stress-induced cardiac myocyte growth) is a major factor underlying heart failure.
Burmeister, BT +5 more
core +1 more source
Regulation of Cardiac PKA Signaling by cAMP and Oxidants
Antioxidants, 2021 Pathologies, such as cancer, inflammatory and cardiac diseases are commonly associated with long-term increased production and release of reactive oxygen species referred to as oxidative stress.
Friederike Cuello +4 more
doaj +1 more source
Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosis [PDF]
, 2010 Sds22 defines protein phosphatase 1 location and function at kinetochores and subsequent activity of aurora B in ...
DeLuca, Jennifer G. +5 more
core +3 more sources
Optimal information transfer in enzymatic networks: A field theoretic formulation [PDF]
Phys. Rev. E 96, 012406 (2017), 2017 Signaling in enzymatic networks is typically triggered by environmental fluctuations, resulting in a series of stochastic chemical reactions, leading to corruption of the signal by noise. For example, information flow is initiated by binding of extracellular ligands to receptors, which is transmitted through a {cascade involving} kinase-phosphatase ...
arxiv +1 more source
Kinase and Phosphatase Engagement Is Dissociated Between Memory Formation and Extinction
Frontiers in Molecular Neuroscience, 2019 Associative long-term memories (LTMs) support long-lasting behavioral changes resulting from sensory experiences. Retrieval of a stable LTM by means of a large number of conditioned stimulus (CS) alone presentations produces inhibition of the original ...
Mario Rafael Pagani +2 more
doaj +1 more source