PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPAR?? at Ser273 [PDF]
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a master regulator of adipose tissue biology. In obesity, phosphorylation of PPAR gamma at Ser273 (pSer273) by cyclin-dependent kinase 5 (CDK5)/extracellular signal-regulated kinase (ERK ...
Choi, Jang Hyun +11 more
core +1 more source
??????????????? ????????? ????????? ?????? ??? ???????????? [PDF]
??????????????? ????????? ???????????? ???????????? ?????? ?????????????????? ??????????????? ?????? ???????????? ??????. ??? ??????????????? ??????????????? ??? ?????? ????????? ???????????? ????????? ??????????????? ????????? ???????????????. ?????? ???
Hwang, Jae-Sam +8 more
core +1 more source
Transgenic CrylAc and CpTI insect-resistant cotton SGK321 is widely adopted for many years in several regions of China, however the understanding of its potential effects on soil enzyme activities is not studied.
Y.J. Zhang +4 more
doaj +1 more source
Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]
We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway.
Alon +54 more
core +3 more sources
Kinase and Phosphatase Engagement Is Dissociated Between Memory Formation and Extinction
Associative long-term memories (LTMs) support long-lasting behavioral changes resulting from sensory experiences. Retrieval of a stable LTM by means of a large number of conditioned stimulus (CS) alone presentations produces inhibition of the original ...
Mario Rafael Pagani +2 more
doaj +1 more source
Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons [PDF]
We examined the effects of the chemokine fractalkine (CX3CL1) on EPSCs evoked by electrical stimulation of Schaffer collaterals in patch-clamped CA1 pyramidal neurons from rat hippocampal slices.
BERTOLLINI, Cristina +8 more
core +1 more source
Phosphorus (P) plays a tremendous and determinant role in plant growth. However, its availability is hampered by the presence of metallic ions in soils.
Regassa Ayana Bayisa
doaj +1 more source
DNA 3 '-Phosphatase Activity Is Critical for Rapid Global Rates of Single-Strand Break Repair following Oxidative Stress [PDF]
Oxidative stress is a major source of chromosome single-strand breaks (SSBs), and the repair of these lesions is retarded in neurodegenerative disease. The rate of the repair of oxidative SSBs is accelerated by XRCC1, a scaffold protein that is essential
Breslin, Claire, Caldecott, Keith W
core +2 more sources
Allostery is an inherent feature of proteins, but it remains challenging to reveal the mechanisms by which allosteric signals propagate. A clearer understanding of this intrinsic circuitry would afford new opportunities to modulate protein function. Here,
Daniel A Keedy +9 more
doaj +1 more source
Phosphate solubilizing bacteria: Isolation of Bacteria and Phosphate Solubilizing Genes, Mechanism and Genetics of Phosphate Solubilization [PDF]
Phosphorus is one of the major plant nutrients that is least available in the soil. There are two components of P in soil, organic and inorganic phosphate.
Mohammad Reza Sarikhani +2 more
doaj +1 more source

