Results 81 to 90 of about 1,424,154 (388)

Cdc25 Phosphatases and Cancer [PDF]

Chemistry & Biology, 2004
The Cdc25 phosphatases function as key regulators of the cell cycle during normal eukaryotic cell division and as mediators of the checkpoint response in cells with DNA damage. The role of Cdc25s in cancer has become increasingly evident in recent years.
Johannes Rudolph, Kolbrun Kristjansdottir   +1 more
openaire   +3 more sources

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38. [PDF]

, 2015
PPM1D phosphatase, also called wild-type p53-induced phosphatase 1, promotes tumor development by inactivating the p53 tumor suppressor pathway.
Chen, X, Xu, E, Zhang, J, Zhang, M
core   +2 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Inoculating plant growth-promoting bacteria and arbuscular mycorrhiza fungi modulates rhizosphere acid phosphatase and nodulation activities and enhance the productivity of soybean (Glycine max)

Frontiers in Plant Science, 2022
Soybean [Glycine max (L.) Merrill] cultivation is important for its dual role as rich source of dietary protein and soil fertility enhancer, but production is constrained by soil nutrient deficiencies.
Christopher Ngosong, Blaise Nangsingnyuy Tatah, Marie Noela Enyoe Olougou, Marie Noela Enyoe Olougou, Christopher Suh, Raymond Ndip Nkongho, Mercy Abwe Ngone, Denis Tange Achiri, Gylaine Vanissa Tchuisseu Tchakounté, Silke Ruppel   +9 more
doaj   +1 more source

Alkaline Phosphatase in Stem Cells

Stem Cells International, 2015
Alkaline phosphatase is an enzyme commonly expressed in almost all living organisms. In humans and other mammals, determinations of the expression and activity of alkaline phosphatase have frequently been used for cell determination in developmental ...
Kateřina Štefková, J. Procházková, J. Pacherník   +2 more
semanticscholar   +1 more source

Critical Role of the Secondary Binding Pocket in Modulating the Enzymatic Activity of DUSP5 toward Phosphorylated ERKs [PDF]

, 2016
DUSP5 is an inducible nuclear dual-specificity phosphatase that specifically interacts with and deactivates extracellular signal-regulated kinases ERK1 and ERK2, which are responsible for cell proliferation, differentiation, and survival. The phosphatase
Bongard, Robert D, Lepley, Michael, Nayak, Jaladhi, Ramchandran, Ramani, Rathore, Rajendra, Sem, Daniel, Talipov, Marat R.   +6 more
core   +3 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Levels of alkaline phosphatase and bilirubin are surrogate end points of outcomes of patients with primary biliary cirrhosis: an international follow-up study.

Gastroenterology, 2014
BACKGROUND & AIMS Noninvasive surrogate end points of long-term outcomes of patients with primary biliary cirrhosis (PBC) are needed to monitor disease progression and evaluate potential treatments. We performed a meta-analysis of individual patient data
W. Lammers, H. V. van Buuren, G. Hirschfield, H. Janssen, P. Invernizzi, A. Mason, C. Ponsioen, A. Floreani, C. Corpechot, M. Mayo, P. Battezzati, A. Parés, F. Nevens, A. Burroughs, K. Kowdley, P. Trivedi, T. Kumagi, A. Cheung, A. Lleo, M. Imam, K. Boonstra, N. Cazzagon, I. Franceschet, R. Poupon, L. Caballería, G. Pieri, Pushpjeet S. Kanwar, K. Lindor, B. Hansen   +28 more
semanticscholar   +1 more source

Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1''-phosphate dephosphorylation by a conserved domain of nsP3. [PDF]

, 2005
The crystal structure of a conserved domain of nonstructural protein 3 (nsP3) from severe acute respiratory syndrome coronavirus (SARS-CoV) has been solved by single-wavelength anomalous dispersion to 1.4 A resolution.
Buchmeier, Michael J, Clayton, Tom, Griffith, Mark, Joseph, Jeremiah S, Kuhn, Peter, Moy, Kin, Neuman, Benjamin W, Saikatendu, Kumar Singh, Stevens, Raymond C, Subramanian, Vanitha, Velasquez, Jeffrey   +10 more
core   +1 more source