Results 91 to 100 of about 3,150,482 (310)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Temporal nutrient dynamics in the Mediterranean Sea in response to anthropogenic inputs

Geophysical Research Letters, 2016
The temporal dynamics of the concentrations of nitrate (N), phosphate (P), and the N:P ratio in the upper water column (200–600 m) of the Mediterranean (MED) Sea were investigated using observational data (~123,100 data points) collected between 1985 and
Ji‐Young Moon, Kitack Lee, Toste Tanhua, Nurit Kress, Il‐Nam Kim   +4 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Calcium phosphate precipitation modeling in a pellet reactor [PDF]

, 2002
The calcium phosphate precipitation in a pellet reactor can be evaluated by two main parameters: the phosphate conversion ratio and the phosphate removal efficiency. The conversion ratio depends mainly on the pH. The pellet reactor efficiency depends not
Azzaro-Pantel, Catherine, Biscans, Béatrice, Cabassud, Michel, Montastruc, Ludovic   +3 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Using Orange Peels (OP) as a Bio-Adsorbent for Removal of phosphate from Wastewater [PDF]

Iranian Journal of Chemistry & Chemical Engineering
The research objective is to study the removal of phosphate from wastewater by Orange Peel (OP). The effectiveness and efficiency of phosphate adsorption by orange peels were investigated by studying the influence of adsorbent mass, particle size, time ...
Abdelmadjid Habchi, Mohamed El-Amine Dahou, Djaafr Mohammed, Said Slimani, Slimane Kalloum   +4 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Acoustic emission characteristics and damage constitutive model of fractured sandstone under uniaxial compression

Scientific Reports
To investigate the statistical laws of acoustic emission energy (AEE) avalanche dynamics of sandstone under varying fracture lengths and dip angles, as well as to determine the relationship between acoustic emission (AE) parameters and damage variables ...
Qiang Liu, Chao Pan, Lin Yan, Xuguang Wang, Shujian Li, Juncai Cao   +5 more
doaj   +1 more source

Characteristics of pore fractal and energy dissipation evolution in sandstone uranium reservoirs under liquid nitrogen cyclic cold impact

Nuclear Engineering and Technology
Liquid nitrogen cyclic cold impact (LNCCI) is an emerging technology for low-temperature fracturing and permeability enhancement in sandstone uranium reservoirs.
Xin Bai, Zhuoli Zhou, Shujian Li, Yan Wang, Guicheng He   +4 more
doaj   +1 more source