Results 111 to 120 of about 2,125,818 (314)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Bone formation on calcium phosphate bone substitute materials

, 2010
A large number of bone substitute materials are available; for which some authors claim osteoconductivity and some osteoinductivity. In order to rank these materials an in vivo analysis was carried out.
Samizadeh, S.
core  

Ibuprofen-loaded calcium phosphate granules : combination of innovative characterization methods to relate mechanical strength to drug location [PDF]

, 2010
This paper studies the impact of the location of a drug substance on the physicochemical and mechanical properties of two types of calcium phosphate granules loaded with seven different contents of ibuprofen, ranging from 1.75% to 46%.
Cazalbou, S., Chevalier, Emilie, Cazalbou, Sophie, Chevalier, E., Viana, Marylène, Dubois, Jessica, Chulia, Dominique, Dubois, Janie, Makein, L., Makein, Lisa   +9 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Diferenciação de genótipos de trigo quanto à tolerância à deficiência de fósforo, em solução hidropônica Differentiation in hydroponic solution of wheat genotypes in relation to tolerance to phosphorus starvation

Revista Brasileira de Ciência do Solo, 2008
O P é um dos elementos mais críticos para a produção agrícola, pois, além de sua grande importância para as plantas, sua disponibilidade é cada vez mais limitada em virtude da progressiva escassez das suas jazidas.
Adriano Alves da Silva, Ingrid Arns, Christina Venzke Simões de Lima, Adriano de Bernardi Schneider, Carla Andrea Delatorre   +4 more
doaj   +1 more source

Analysis of serum phosphate control and phosphate binder utilization in incident hemodialysis patients

, 2014
Kimberly F Farrand,1 J Brian Copley,1 Jamie Heise,1 Moshe Fridman,2 Michael S Keith,1 Lynne Poole3 1Shire, Wayne, PA, USA; 2AMF Consulting, Los Angeles, CA, USA; 3Shire, Basingstoke, UK Abstract: The purpose of this study was to conduct a retrospective ...
Farr, KF, Copley JB, Fridman M, Poole L, Heise J, Keith MS   +6 more
core  

Tetracalcium phosphate and biphasic tetracalcium phosphate/tricalcium phosphate powders' effects evaluation on human osteoblasts.

, 2020
BACKGROUND Calcium ions levels in bone niches have been demonstrated to severely influence new bone formation. Osteoinductive scaffolds containing calcium have been largely studied to control the release of calcium in bone regeneration and tissue ...
Mozzoni, Beatrice, Ghezzi, Benedetta, Toffoli, Andrea, Macaluso, Guido M, Meglioli, Matteo, Vurro, Filippo, Ghiacci, Giulia, Parisi, Ludovica, Alfieri, Ilaria   +8 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Intelligent prediction system for surface movement and deformation in the subsequent filling mining of inclined, thick, and large ore

Scientific Reports
Guizhou is a mountainous region that faces numerous engineering challenges during the mining of thick inclined ore bodies, including complex geological conditions, limited monitoring systems, and insufficient on-site monitoring.
Xinxin Huang, Chen Wang, Xuyu Li, Weichao Ouyang, Yujun Zuo, Shan Jiang   +5 more
doaj   +1 more source

The dissolution of mineral phosphate in soil

, 1985
The use of cheap, sparingly soluble calcium phosphate fertilizers is increasitgly widespread, particularly in the extensive agriculture systems of the tropics where very high yields are not sought, and phosphate deficiency is a major limitation to crop ...
Kirk, G. J. D.
core   +1 more source