Results 111 to 120 of about 2,299,534 (313)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Polyhydroxyalkanoate-based thin films : characterization and optimization for calcium phosphate crystallization [PDF]

open access: yes, 2013
Novel polymer-inorganic composites attract scientific and commercial attention as potential biomaterials for orthopedic applications, due to the fact that currently used materials have still many drawbacks, e.g.
Jagoda, Agnieszka Maria
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

The Effects of Polymer–Nitrogen Fertilizer on Biomes in Drip-Irrigated Wheat Soil

open access: yesMicroorganisms
Polymer application combined with nitrogen (N) fertilization can increase soil N transformation efficiency. However, the mechanism of polymer influencing soil biocommunity characteristics and nitrogen transformation is still unclear.
Yan Sun   +6 more
doaj   +1 more source

In vitro DISSOLUTION OF ACIDULATED ROCK PHOSPHATE BY PHOSPHATE SOLUBILIZING MICROORGANISMS

open access: yesActa Biológica Colombiana, 2015
The low availability of phosphorus (P) in the soil and the high cost of P fertilization are factors that limit agricultural productivity. A biotechnological alternative for to handle this problem is to use soil microorganisms capable of dissolving rock ...
Ángela Patricia Moreno Quevedo   +2 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Phosphate sensing [PDF]

open access: yesCurrent Opinion in Nephrology and Hypertension, 2009
To discuss findings suggesting the presence of a phosphate-sensing mechanism in the various organs and the presence of a novel intestinal effector that alters renal phosphate excretion after the ingestion of a phosphate-containing meal.Although phosphate homeostasis is controlled by a variety of hormones (such as parathyroid hormone and 1,25 ...
openaire   +2 more sources

Molecular studies on plant glycerol-s-phosphate acyltransferases [PDF]

open access: yes, 2000
The main objective of this research is to advance our understanding of the biochemical properties and the structure-function relationships of the chloroplast glycerol-3-phosphate acyltransferases in plants.
Kroon, Johannes Theodorus Maria
core  

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