Results 131 to 140 of about 2,299,534 (313)
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
The Role of Phosphorus Sources and Phytase in Growth Performance and Feed Digestibility in Broilers
AnimalsPhosphorus (P) is an essential mineral in poultry nutrition, but its low bioavailability from conventional feed ingredients presents a significant challenge for efficient utilization.
Edouard Coudert +6 more
doaj +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Applied SciencesAlthough constructed wetlands (CWs) are a viable solution for wastewater treatment, substrate selection significantly affects their performance. This study evaluated the adsorption behavior of ammonium and orthophosphate on natural zeolite (coarse- and ...
Georgios D. Gikas +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source
Scientific ReportsGuizhou is a mountainous region that faces numerous engineering challenges during the mining of thick inclined ore bodies, including complex geological conditions, limited monitoring systems, and insufficient on-site monitoring.
Xinxin Huang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
Phosphate inorganic transport (Pit) system in Escherichia coli and Acinetobacter johnsonii
, 1994 Although the phosphate inorganic transport (Pit) system is the major secondary uptake system for Pi in Escherichia coli, its transport mechanism has been studied less extensively than that of the Pi-linked antiporters for sn-glycerol 3-phosphate (GlpT ...
Konings, Wil N. (author) +4 more
core +1 more source
Frontiers in NeurologyBackgroundPhosphate disorders, including hypophosphatemia and hyperphosphatemia, influence the prognosis of patients. We designed this study to explore the relationship between serum phosphate levels and mortality in traumatic brain injury (TBI) patients.
Ruoran Wang +3 more
doaj +1 more source
Structure of Phosphate Based Bioactive Glasses
Structure of phosphate glass can be represented using Qn terminogy, from structure a solubility can be ...
Stunda-Zujeva, Agnese +1 more
core